UBE2B

UBE2B
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1JAS, 2Y4W, 2YB6, 2YBF
Dynodwyr
Cyfenwau	UBE2B, E2-17kDa, HHR6B, HR6B, RAD6B, UBC2, ubiquitin conjugating enzyme E2 B
Dynodwyr allanol	OMIM: 179095 HomoloGene: 101298 GeneCards: UBE2B
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • ubiquitin conjugating enzyme activity; • ubiquitin protein ligase binding;
Cydrannau o'r gell	• cytoplasm; • bilen; • Cellbilen; • replication fork; • HULC complex; • nucleoplasm; • XY body; • chromatin; • cnewyllyn cell;
Prosesau biolegol	• chiasma assembly; • histone H2A ubiquitination; • negative regulation of cAMP-mediated signaling; • postreplication repair; • ubiquitin-dependent protein catabolic process; • protein K63-linked ubiquitination; • meiotic telomere clustering; • positive regulation of reciprocal meiotic recombination; • protein stabilization; • protein polyubiquitination; • negative regulation of apoptotic process; • in utero embryonic development; • protein monoubiquitination; • sperm axoneme assembly; • cellular response to DNA damage stimulus; • protein K11-linked ubiquitination; • histone lysine demethylation; • protein K48-linked ubiquitination; • GO:0033127, GO:2000281, GO:2000817 regulation of histone modification; • spermatogenesis; • canonical Wnt signaling pathway; • synaptonemal complex organization; • response to UV; • proteasome-mediated ubiquitin-dependent protein catabolic process; • protein autoubiquitination; • GO:0100026 DNA repair; • protein ubiquitination; • positive regulation of canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7320
	n/a
	ENSG00000119048
	n/a
	P63146
	n/a
	NM_003337
	n/a
	NP_003328
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2B yw UBE2B a elwir hefyd yn Ubiquitin conjugating enzyme E2 B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 5, band 5q31.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2B.

HR6B
UBC2
HHR6B
RAD6B
E2-17kDa

Llyfryddiaeth

"UBE2B mRNA alterations are associated with severe oligozoospermia in infertile men. ". Mol Hum Reprod. 2013. PMID 23378580.
"Genetic association of UBE2B variants with susceptibility to male infertility in a Northeast Chinese population. ". Genet Mol Res. 2012. PMID 23079972.
"Pharmacological targeting of RAD6 enzyme-mediated translesion synthesis overcomes resistance to platinum-based drugs. ". J Biol Chem. 2017. PMID 28490629.
"Rad6 upregulation promotes stem cell-like characteristics and platinum resistance in ovarian cancer. ". Biochem Biophys Res Commun. 2016. PMID 26679603.
"A functional variant in the UBE2B gene promoter is associated with idiopathic azoospermia.". Reprod Biol Endocrinol. 2015. PMID 26223869.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] UBE2B - Cronfa NCBI

[1]

[2]