UBE2E1

UBE2E1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1XR9, 3BZH, 4JJQ
Dynodwyr
Cyfenwau	UBE2E1, UBCH6, ubiquitin conjugating enzyme E2 E1
Dynodwyr allanol	OMIM: 602916 HomoloGene: 84372 GeneCards: UBE2E1
EC number	2.3.2.24
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • ISG15 transferase activity; • GO:0050372 ubiquitin-protein transferase activity; • GO:0001948, GO:0016582 protein binding; • ATP binding; • ubiquitin conjugating enzyme activity;
Cydrannau o'r gell	• cytosol; • ubiquitin ligase complex; • nucleoplasm; • cnewyllyn cell;
Prosesau biolegol	• histone monoubiquitination; • ubiquitin-dependent protein catabolic process; • protein polyubiquitination; • protein K48-linked ubiquitination; • ISG15-protein conjugation; • anaphase-promoting complex-dependent catabolic process; • histone H2B ubiquitination; • protein ubiquitination; • regulation of mitotic cell cycle phase transition;
	Sources:Amigo / QuickGO
Orthologau
	7324
	n/a
	ENSG00000170142
	n/a
	P51965
	n/a
	NM_001202476; NM_003341; NM_182666
	n/a
	NP_001189405; NP_003332; NP_872607; NP_003332.1
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2E1 yw UBE2E1 a elwir hefyd yn Ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast), isoform CRA_a ac Ubiquitin-conjugating enzyme E2 E1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 3, band 3p24.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2E1.

UBCH6

Llyfryddiaeth

"UbE2E1/UBCH6 Is a Critical in VivoE2 for the PRC1-catalyzed Ubiquitination of H2A at Lys-119. ". J Biol Chem. 2017. PMID 28073915.
"A key lysine residue in the AXH domain of ataxin-1 is essential for its ubiquitylation. ". Biochim Biophys Acta. 2015. PMID 25641559.
"Microarray-based analysis and clinical validation identify ubiquitin-conjugating enzyme E2E1 (UBE2E1) as a prognostic factor in acute myeloid leukemia. ". J Hematol Oncol. 2016. PMID 27855695.
"The structure and conformation of Lys63-linked tetraubiquitin. ". J Mol Biol. 2009. PMID 19664638.
"Mechanisms underlying ubiquitination.". Annu Rev Biochem. 2001. PMID 11395416.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] UBE2E1 - Cronfa NCBI

[1]

[2]