UBE2N

UBE2N
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1J7D, 2C2V, 3HCT, 3HCU, 3VON, 3W31, 4DHI, 4DHJ, 4DHZ, 4IP3, 4NR3, 4NRG, 4NRI, 4ONL, 4ONM, 4ONN, 4ORH, 4TKP, 5AIT, 5AIU, 4WHV
Dynodwyr
Cyfenwau	UBE2N, HEL-S-71, UBC13, UBCHBEN; UBC13, UbcH-ben, UbcH13, ubiquitin conjugating enzyme E2 N, UBCHBEN
Dynodwyr allanol	OMIM: 603679 HomoloGene: 128406 GeneCards: UBE2N
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • ubiquitin binding; • GO:0001948, GO:0016582 protein binding; • ATP binding; • ubiquitin protein ligase binding; • RNA binding; • GO:0050372 ubiquitin-protein transferase activity; • ubiquitin conjugating enzyme activity;
Cydrannau o'r gell	• cytoplasm; • cytosol; • UBC13-UEV1A complex; • ubiquitin ligase complex; • nucleoplasm; • extracellular exosome; • UBC13-MMS2 complex; • cnewyllyn cell; • fibrillar center; • GO:0009327 protein-containing complex;
Prosesau biolegol	• postreplication repair; • protein K63-linked ubiquitination; • regulation of DNA repair; • DNA double-strand break processing; • GO:1900404 positive regulation of DNA repair; • stimulatory C-type lectin receptor signaling pathway; • proteolysis; • cellular response to DNA damage stimulus; • Fc-epsilon receptor signaling pathway; • global genome nucleotide-excision repair; • GO:0033129 positive regulation of histone modification; • positive regulation of ubiquitin-protein transferase activity; • protein ubiquitination; • regulation of histone ubiquitination; • positive regulation of I-kappaB kinase/NF-kappaB signaling; • T cell receptor signaling pathway; • double-strand break repair via nonhomologous end joining; • nucleotide-binding oligomerization domain containing signaling pathway; • histone ubiquitination; • GO:0100026 DNA repair; • double-strand break repair via homologous recombination; • JNK cascade; • positive regulation of NF-kappaB transcription factor activity; • ubiquitin-dependent protein catabolic process; • interleukin-1-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7334
	n/a
	ENSG00000177889
	n/a
	P61088
	n/a
	NM_003348
	n/a
	NP_003339
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UBE2N yw UBE2N a elwir hefyd yn Ubiquitin conjugating enzyme E2 N (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12q22.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UBE2N.

UBC13
UbcH13
HEL-S-71
UbcH-ben
UBCHBEN
UBC13

Llyfryddiaeth

"The Shigella flexneri effector OspI deamidates UBC13 to dampen the inflammatory response. ". Nature. 2012. PMID 22407319.
"Cloning and expression of cDNA encoding a human ubiquitin-conjugating enzyme similar to the Drosophila bendless gene product. ". J Biochem. 1996. PMID 8902611.
"A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. ". Cell Death Dis. 2014. PMID 24556694.
"Complex structure of OspI and Ubc13: the molecular basis of Ubc13 deamidation and convergence of bacterial and host E2 recognition. ". PLoS Pathog. 2013. PMID 23633953.
"Structural basis for the recognition of Ubc13 by the Shigella flexneri effector OspI.". J Mol Biol. 2013. PMID 23542009.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] UBE2N - Cronfa NCBI

[1]

[2]