UHRF1

UHRF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2FAZ, 2L3R, 2LGG, 2LGK, 2LGL, 2PB7, 3ASK, 3ASL, 3BI7, 3CLZ, 3DB3, 3DB4, 3DWH, 3FL2, 3SHB, 3SOU, 3SOW, 3SOX, 3T6R, 3ZVY, 3ZVZ, 4GY5, 4QQD, 5C6D, 5IAY
Dynodwyr
Cyfenwau	UHRF1, ICBP90, Np95, RNF106, hNP95, hhuNp95, TDRD22, ubiquitin like with PHD and ring finger domains 1
Dynodwyr allanol	OMIM: 607990 HomoloGene: 7866 GeneCards: UHRF1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:1904264, GO:1904822, GO:0090622, GO:0090302 ubiquitin protein ligase activity; • hemi-methylated DNA-binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • methyl-CpG binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • metal ion binding; • GO:0050372 ubiquitin-protein transferase activity; • methylated histone binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • transferase activity; • zinc ion binding; • GO:0031493 histone binding;
Cydrannau o'r gell	• GO:0035327 euchromatin; • nuclear matrix; • replication fork; • GO:0035328 heterochromatin; • cnewyllyn cell;
Prosesau biolegol	• histone monoubiquitination; • GO:0051247, GO:0051200 positive regulation of protein metabolic process; • GO:0009373 regulation of transcription, DNA-templated; • maintenance of DNA methylation; • positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity; • GO:1901227 negative regulation of transcription by RNA polymerase II; • transcription, DNA-templated; • regulation of DNA methylation-dependent heterochromatin assembly; • cellular response to DNA damage stimulus; • protein ubiquitination; • cell cycle; • cell population proliferation; • histone ubiquitination; • GO:0100026 DNA repair; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • protein autoubiquitination; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization; • ubiquitin-dependent protein catabolic process; • regulation of epithelial cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	29128
	n/a
	ENSG00000276043
	n/a
	Q96T88
	n/a
	NM_001048201; NM_001290050; NM_001290051; NM_001290052; NM_013282
	n/a
	NP_001041666; NP_001276979; NP_001276980; NP_001276981; NP_037414
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn UHRF1 yw UHRF1 a elwir hefyd yn Ubiquitin like with PHD and ring finger domains 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn UHRF1.

Np95
hNP95
ICBP90
RNF106
TDRD22
hUHRF1
huNp95

Llyfryddiaeth

"UHRF1 gene silencing inhibits cell proliferation and promotes cell apoptosis in human cervical squamous cell carcinoma CaSki cells. ". J Ovarian Res. 2016. PMID 27431502.
"UHRF1 overexpression is involved in cell proliferation and biochemical recurrence in prostate cancer after radical prostatectomy. ". J Exp Clin Cancer Res. 2016. PMID 26884069.
"Overexpression of UHRF1 gene correlates with the major clinicopathological parameters in urinary bladder cancer. ". Int Braz J Urol. 2017. PMID 28128913.
"Signalling pathways in UHRF1-dependent regulation of tumor suppressor genes in cancer. ". J Exp Clin Cancer Res. 2016. PMID 27839516.
"Clinicopathological analysis of UHRF1 expression in medulloblastoma tissues and its regulation on tumor cell proliferation.". Med Oncol. 2016. PMID 27449774.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] UHRF1 - Cronfa NCBI

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[2]