VAMP1

VAMP1
Dynodwyr
Cyfenwau	VAMP1, SPAX1, SYB1, VAMP-1, vesicle associated membrane protein 1, CMS25
Dynodwyr allanol	OMIM: 185880 HomoloGene: 40678 GeneCards: VAMP1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• SNAP receptor activity; • GO:0001948, GO:0016582 protein binding; • syntaxin binding;
Cydrannau o'r gell	• synaptic vesicle membrane; • synapse; • integral component of membrane; • mitocondria; • tertiary granule membrane; • azurophil granule membrane; • cell junction; • integral component of plasma membrane; • neuron projection; • bilen; • cell surface; • specific granule membrane; • mitochondrial outer membrane; • cytoplasmic vesicle membrane; • GO:0016023 cytoplasmic vesicle; • cytosol; • SNARE complex; • integral component of synaptic vesicle membrane; • neuromuscular junction; • presynapse; • glutamatergic synapse;
Prosesau biolegol	• SNARE complex assembly; • vesicle fusion; • vesicle-mediated transport; • exocytosis; • synaptic vesicle priming; • regulation of synaptic vesicle fusion to presynaptic active zone membrane;
	Sources:Amigo / QuickGO
Orthologau
	6843
	n/a
	ENSG00000139190
	n/a
	P23763
	n/a
	NM_001297438; NM_014231; NM_016830; NM_199245
	n/a
	NP_001284367; NP_055046; NP_058439; NP_954740
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAMP1 yw VAMP1 a elwir hefyd yn Vesicle associated membrane protein 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.31.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAMP1.

SYB1
SPAX1
VAMP-1

Llyfryddiaeth

"VAMP-1 has a highly variable C-terminus generated by alternative splicing. ". Biochem Biophys Res Commun. 1999. PMID 10544008.
"Genetically-controlled Vesicle-Associated Membrane Protein 1 expression may contribute to Alzheimer's pathophysiology and susceptibility. ". Mol Neurodegener. 2015. PMID 25881291.
"Homozygous mutations in VAMP1 cause a presynaptic congenital myasthenic syndrome. ". Ann Neurol. 2017. PMID 28253535.
"Characterization of SNARE proteins in human pituitary adenomas: targeted secretion inhibitors as a new strategy for the treatment of acromegaly?". J Clin Endocrinol Metab. 2013. PMID 24152687.
"Specificity of botulinum protease for human VAMP family proteins.". Microbiol Immunol. 2012. PMID 22289120.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] VAMP1 - Cronfa NCBI

[1]

[2]