VAV1

VAV1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CRH, 2LCT, 2MC1, 2ROR, 3BJI, 3KY9
Dynodwyr
Cyfenwau	VAV1, VAV, vav guanine nucleotide exchange factor 1
Dynodwyr allanol	OMIM: 164875 HomoloGene: 3961 GeneCards: VAV1
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• guanyl-nucleotide exchange factor activity; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • phosphatidylinositol-4,5-bisphosphate 3-kinase activity; • phosphotyrosine residue binding;
Cydrannau o'r gell	• cytosol; • cell-cell junction; • Cellbilen;
Prosesau biolegol	• regulation of cell size; • GO:0007243 intracellular signal transduction; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • T cell costimulation; • neutrophil chemotaxis; • reactive oxygen species metabolic process; • platelet activation; • Fc-epsilon receptor signaling pathway; • GO:0032320, GO:0032321, GO:0032855, GO:0043089, GO:0032854 positive regulation of GTPase activity; • T cell differentiation; • vascular endothelial growth factor receptor signaling pathway; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • ffagocytosis; • positive regulation of apoptotic process; • integrin-mediated signaling pathway; • regulation of Rho protein signal transduction; • regulation of small GTPase mediated signal transduction; • positive regulation of natural killer cell mediated cytotoxicity; • T cell activation; • positive regulation of cell adhesion; • GO:0009373 regulation of transcription, DNA-templated; • phosphatidylinositol phosphate biosynthetic process; • small GTPase mediated signal transduction; • G protein-coupled receptor signaling pathway; • positive regulation of protein kinase B signaling; • cytokine-mediated signaling pathway; • positive regulation of Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologau
	7409
	n/a
	ENSG00000141968
	n/a
	P15498
	n/a
	NM_001258206; NM_001258207; NM_005428
	n/a
	NP_001245135; NP_001245136; NP_005419
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV1 yw VAV1 a elwir hefyd yn Vav guanine nucleotide exchange factor 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 19, band 19p13.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAV1.

VAV

Llyfryddiaeth

"Estrogen induces Vav1 expression in human breast cancer cells. ". PLoS One. 2014. PMID 24905577.
"Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells. ". Cell Signal. 2014. PMID 24880064.
"Vav1 expression is increased in esophageal squamous cell carcinoma and indicates poor prognosis. ". Biochem Biophys Res Commun. 2017. PMID 28336434.
"VAV1 regulates experimental autoimmune arthritis and is associated with anti-CCP negative rheumatoid arthritis. ". Genes Immun. 2017. PMID 28053322.
"Mutation of Vav1 adaptor region reveals a new oncogenic activation.". Oncotarget. 2015. PMID 25426554.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] VAV1 - Cronfa NCBI

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[2]