VAV2

VAV2
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2DLZ, 2DM1, 2LNW, 2LNX, 4ROJ
Dynodwyr
Cyfenwau	VAV2, VAV-2, vav guanine nucleotide exchange factor 2
Dynodwyr allanol	OMIM: 600428 HomoloGene: 2530 GeneCards: VAV2
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• guanyl-nucleotide exchange factor activity; • epidermal growth factor receptor binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • phosphotyrosine residue binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • Cellbilen;
Prosesau biolegol	• regulation of cell size; • GO:0007243 intracellular signal transduction; • Fc-gamma receptor signaling pathway involved in phagocytosis; • GO:0043087, GO:0032313, GO:0032319, GO:0032314, GO:0043088 regulation of GTPase activity; • ephrin receptor signaling pathway; • positive regulation of phosphatidylinositol 3-kinase activity; • platelet activation; • Fc-epsilon receptor signaling pathway; • vascular endothelial growth factor receptor signaling pathway; • cell projection assembly; • angiogenesis; • positive regulation of apoptotic process; • regulation of Rho protein signal transduction; • regulation of small GTPase mediated signal transduction; • cell migration; • GO:0072468 signal transduction; • lamellipodium assembly; • small GTPase mediated signal transduction; • G protein-coupled receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7410
	n/a
	ENSG00000160293
	n/a
	P52735
	n/a
	NM_001134398; NM_003371
	n/a
	NP_001127870; NP_003362
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VAV2 yw VAV2 a elwir hefyd yn Vav guanine nucleotide exchange factor 2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 9, band 9q34.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VAV2.

VAV-2

Llyfryddiaeth

"Guanine exchange factor Vav2: a novel potential target for the development of drugs effective in the prevention of papillomavirus infection and disease. ". Am J Ther. 2009. PMID 19451809.
"Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. ". Mol Cell Biol. 2000. PMID 10982832.
"Upregulated Vav2 in gastric cancer tissues promotes tumor invasion and metastasis. ". Tumour Biol. 2017. PMID 28459214.
"Potassium-chloride cotransporter 3 interacts with Vav2 to synchronize the cell volume decrease response with cell protrusion dynamics. ". PLoS One. 2013. PMID 23724134.
"Balanced Vav2 GEF activity regulates neurite outgrowth and branching in vitro and in vivo.". Mol Cell Neurosci. 2010. PMID 20298788.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] VAV2 - Cronfa NCBI

[1]

[2]