VEGFB

VEGFB
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2C7W, 2VWE, 2XAC
Dynodwyr
Cyfenwau	VEGFB, VEGFL, VRF, vascular endothelial growth factor B
Dynodwyr allanol	OMIM: 601398 HomoloGene: 87131 GeneCards: VEGFB
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• heparin binding; • protein homodimerization activity; • GO:0001948, GO:0016582 protein binding; • protein heterodimerization activity; • chemoattractant activity; • growth factor activity; • vascular endothelial growth factor receptor 1 binding; • vascular endothelial growth factor receptor 2 binding; • vascular endothelial growth factor receptor 3 binding; • vascular endothelial growth factor receptor binding;
Cydrannau o'r gell	• bilen; • intracellular anatomical structure; • extracellular region; • platelet alpha granule lumen; • extracellular space;
Prosesau biolegol	• GO:1904089 negative regulation of neuron apoptotic process; • positive regulation of vascular endothelial growth factor receptor signaling pathway; • positive regulation of protein kinase B signaling; • cardiac muscle contraction; • protein O-linked glycosylation; • platelet degranulation; • negative regulation of apoptotic process; • coronary vasculature development; • negative regulation of gene expression; • heart development; • positive regulation of vascular permeability; • positive regulation of vascular wound healing; • positive regulation of ERK1 and ERK2 cascade; • positive regulation of peptidyl-tyrosine phosphorylation; • positive regulation of cell division; • positive chemotaxis; • response to hypoxia; • angiogenesis; • positive regulation of endothelial cell proliferation; • positive regulation of angiogenesis; • vascular endothelial growth factor receptor signaling pathway; • induction of positive chemotaxis; • positive regulation of mast cell chemotaxis; • regulation of signaling receptor activity; • positive regulation of protein phosphorylation; • sprouting angiogenesis; • vascular endothelial growth factor signaling pathway;
	Sources:Amigo / QuickGO
Orthologau
	7423
	n/a
	ENSG00000173511
	n/a
	P49765
	n/a
	NM_003377; NM_001243733
	n/a
	NP_001230662; NP_003368
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn VEGFB yw VEGFB a elwir hefyd yn Vascular endothelial growth factor B (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 11, band 11q13.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn VEGFB.

VRF
VEGFL

Llyfryddiaeth

"Vascular endothelial growth factor B coordinates metastasis of non-small cell lung cancer. ". Tumour Biol. 2015. PMID 25424698.
"Clinical association of circulating VEGF-B levels with hyperlipidemia and target organ damage in type 2 diabetic patients. ". J Biol Regul Homeost Agents. 2014. PMID 25001655.
"Vascular Endothelial Growth Factor-B Overexpressing Hearts Are Not Protected From Transplant-Associated Ischemia-Reperfusion Injury. ". Exp Clin Transplant. 2017. PMID 27588416.
"Serum vascular endothelial growth factor B is elevated in women with polycystic ovary syndrome and can be decreased with metformin treatment. ". Clin Endocrinol (Oxf). 2016. PMID 26387747.
"Frameshift mutation of an angiogenesis factor VEGFB and its mutational heterogeneity in colorectal cancers.". Pathol Oncol Res. 2015. PMID 25633991.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] VEGFB - Cronfa NCBI

[1]

[2]