WDR5

WDR5
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2CNX, 2CO0, 2G99, 2G9A, 2GNQ, 2H13, 2H14, 2H68, 2H6K, 2H6N, 2H6Q, 2H9L, 2H9M, 2H9N, 2H9P, 2O9K, 3EG6, 3EMH, 3MXX, 3N0D, 3N0E, 3P4F, 3PSL, 3SMR, 3UR4, 3UVK, 3UVL, 3UVM, 3UVN, 3UVO, 4A7J, 4CY1, 4CY2, 4ERQ, 4ERY, 4ERZ, 4ES0, 4ESG, 4EWR, 4GM3, 4GM8, 4GM9, 4GMB, 4IA9, 4O45, 4QL1, 4Y7R, 5EAL, 5EAP, 5EAR, 4QQE, 5EAM
Dynodwyr
Cyfenwau	WDR5, BIG-3, CFAP89, SWD3, WD repeat-containing protein 5, WD repeat domain 5
Dynodwyr allanol	OMIM: 609012 HomoloGene: 59931 GeneCards: WDR5
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• histone methyltransferase activity (H3-K4 specific); • histone acetyltransferase activity (H4-K8 specific); • histone acetyltransferase activity (H4-K5 specific); • methylated histone binding; • GO:0001948, GO:0016582 protein binding; • histone acetyltransferase activity (H4-K16 specific); • histone-lysine N-methyltransferase activity; • GO:0031493 histone binding;
Cydrannau o'r gell	• Set1C/COMPASS complex; • intracellular anatomical structure; • nucleoplasm; • MLL1 complex; • MLL3/4 complex; • histone acetyltransferase complex; • cnewyllyn cell; • histone methyltransferase complex; • ciliary basal body;
Prosesau biolegol	• skeletal system development; • GO:0009373 regulation of transcription, DNA-templated; • transcription, DNA-templated; • histone H4-K5 acetylation; • histone H3-K4 methylation; • histone H3 acetylation; • histone H4-K16 acetylation; • neuron projection development; • histone H4-K8 acetylation; • cilium assembly; • post-translational protein modification; • regulation of megakaryocyte differentiation; • GO:0031497, GO:0006336, GO:0034724, GO:0001301, GO:0007580, GO:0034652, GO:0010847 chromatin organization;
	Sources:Amigo / QuickGO
Orthologau
	11091
	n/a
	ENSG00000196363
	n/a
	P61964
	n/a
	NM_017588; NM_052821
	n/a
	NP_060058; NP_438172
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WDR5 yw WDR5 a elwir hefyd yn WD repeat domain 5 ac WD repeat-containing protein 5 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 9, band 9q34.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WDR5.

SWD3
BIG-3
CFAP89

Llyfryddiaeth

"Wdr5, a novel WD repeat protein, regulates osteoblast and chondrocyte differentiation in vivo. ". J Musculoskelet Neuronal Interact. 2005. PMID 16340128.
"WDR5 positively regulates p53 stability by inhibiting p53 ubiquitination. ". Biochem Biophys Res Commun. 2017. PMID 28412363.
"WDR5 Expression Is Prognostic of Breast Cancer Outcome. ". PLoS One. 2015. PMID 26355959.
"Upregulated WDR5 promotes proliferation, self-renewal and chemoresistance in bladder cancer via mediating H3K4 trimethylation. ". Sci Rep. 2015. PMID 25656485.
"The effect of Asp-His-Ser/Thr-Trp tetrad on the thermostability of WD40-repeat proteins.". Biochemistry. 2010. PMID 20939513.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] WDR5 - Cronfa NCBI

[1]

[2]