WIPF1

WIPF1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2A41
Dynodwyr
Cyfenwau	WIPF1, PRPL-2, WASPIP, WIP, WAS2, WAS/WASL interacting protein family member 1
Dynodwyr allanol	OMIM: 602357 HomoloGene: 86891 GeneCards: WIPF1
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• actin binding; • profilin binding; • GO:0001948, GO:0016582 protein binding; • SH3 domain binding; • actin filament binding;
Cydrannau o'r gell	• actin cytoskeleton; • cytoplasm; • cytosol; • cell projection; • ruffle; • Cytosgerbwd; • GO:0016023 cytoplasmic vesicle; • Microffilament; • actin cortical patch;
Prosesau biolegol	• actin polymerization or depolymerization; • Fc-gamma receptor signaling pathway involved in phagocytosis; • response to other organism; • actin filament-based movement; • GO:0034622 protein-containing complex assembly; • actin cortical patch assembly; • endocytosis; • positive regulation of actin nucleation; • actin cortical patch localization;
	Sources:Amigo / QuickGO
Orthologau
	7456
	n/a
	ENSG00000115935
	n/a
	O43516
	n/a
	NM_001077269; NM_003387
	n/a
NP_001070737; NP_003378; NP_001362761; NP_001362762; NP_001362763;
	NP_001362764; NP_001362765; NP_001362766; NP_001362767; NP_001362768
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn WIPF1 yw WIPF1 a elwir hefyd yn WAS/WASL-interacting protein family member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 2, band 2q31.1.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn WIPF1.

WIP
WAS2
PRPL-2
WASPIP

Llyfryddiaeth

"WIP is essential for lytic granule polarization and NK cell cytotoxicity. ". Proc Natl Acad Sci U S A. 2008. PMID 18258743.
"WASP-interacting protein (WIP): working in polymerisation and much more. ". Trends Cell Biol. 2007. PMID 17949983.
"WIP remodeling actin behind the scenes: how WIP reshapes immune and other functions. ". Int J Mol Sci. 2012. PMID 22837718.
"A novel primary human immunodeficiency due to deficiency in the WASP-interacting protein WIP. ". J Exp Med. 2012. PMID 22231303.
"An expression module of WIPF1-coexpressed genes identifies patients with favorable prognosis in three tumor types.". J Mol Med (Berl). 2009. PMID 19399471.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] WIPF1 - Cronfa NCBI

[1]

[2]