YBX3 |
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![](//upload.wikimedia.org/wikipedia/commons/thumb/0/01/Protein_CSDA_PDB_1h95.png/250px-Protein_CSDA_PDB_1h95.png) |
Dynodwyr |
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Cyfenwau | YBX3, CSDA, CSDA1, DBPA, ZONAB, Y-box binding protein 3 |
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Dynodwyr allanol | OMIM: 603437 HomoloGene: 2708 GeneCards: YBX3 |
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Ontoleg y genyn |
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Gweithrediad moleciwlaidd | • DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001106 transcription corepressor activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • mRNA 3'-UTR binding • single-stranded DNA binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific • nucleic acid binding • double-stranded DNA binding • RNA binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0001948, GO:0016582 protein binding • polysome binding
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Cydrannau o'r gell | • polysome • bicellular tight junction • perinuclear region of cytoplasm • cnewyllyn cell • cytoplasm • cytosol
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Prosesau biolegol | • male gonad development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress • negative regulation of necroptotic process • positive regulation of cytoplasmic translation • cellular response to tumor necrosis factor • positive regulation of organ growth • negative regulation of apoptotic process • in utero embryonic development • GO:1901227 negative regulation of transcription by RNA polymerase II • transcription, DNA-templated • cellular hyperosmotic response • negative regulation of skeletal muscle tissue development • spermatogenesis • response to cold • fertilization • 3'-UTR-mediated mRNA stabilization
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Sources:Amigo / QuickGO |
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Orthologau |
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Species | Bod dynol | Llygoden |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | | |
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RefSeq (protein) | | |
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Lleoliad (UCSC) | n/a | n/a |
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PubMed search | [1] | n/a |
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Wicidata |
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Protein sy'n cael ei godio yn y corff dynol gan y genyn YBX3 yw YBX3 a elwir hefyd yn Y-box binding protein 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 12, band 12p13.2.[2]
Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YBX3.
- "DNA binding protein A expression and methylation status in hepatocellular carcinoma and the adjacent tissue. ". Int J Oncol. 2012. PMID 22159460.
- "Upregulation of human DNA binding protein A (dbpA) in gastric cancer cells. ". Acta Pharmacol Sin. 2009. PMID 19749785.
- "Gene expression profile analysis of dbpA knockdown in colorectal cancer cells. ". Cell Biol Int. 2016. PMID 27569444.
- "RNAi-mediated downregulation of DNA binding protein A inhibits tumorigenesis in colorectal cancer. ". Int J Mol Med. 2016. PMID 27430286.
- "Validation of housekeeping gene and impact on normalized gene expression in clear cell renal cell carcinoma: critical reassessment of YBX3/ZONAB/CSDA expression.". BMC Mol Biol. 2014. PMID 24885929.