YWHAZ

YWHAZ
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1IB1, 1QJA, 1QJB, 2C1J, 2C1N, 2O02, 2WH0, 3CU8, 3NKX, 3RDH, 4BG6, 4FJ3, 4HKC, 4IHL, 4N7G, 4N7Y, 4N84, 4WRQ, 4ZDR, 1A38, 1A4O, 1A37, 5D2D, 5D3F, 5EXA, 5EWZ
Dynodwyr
Cyfenwau	YWHAZ, 14-3-3-zeta, HEL-S-3, HEL4, KCIP-1, YWHAD, HEL-S-93, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta, POPCHAS
Dynodwyr allanol	OMIM: 601288 HomoloGene: 56528 GeneCards: YWHAZ
Patrwm RNA pattern
	; ; ; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• protein domain specific binding; • transcription factor binding; • GO:0001948, GO:0016582 protein binding; • identical protein binding; • protein kinase binding; • ubiquitin protein ligase binding; • RNA binding; • cadherin binding; • transmembrane transporter binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • blood microparticle; • focal adhesion; • melanosome; • nucleoplasm; • mitocondria; • extracellular exosome; • cytoplasmic vesicle membrane; • extracellular space; • cnewyllyn cell; • fesigl; • glutamatergic synapse; • hippocampal mossy fiber to CA3 synapse;
Prosesau biolegol	• regulation of mRNA stability; • negative regulation of apoptotic process; • establishment of Golgi localization; • Golgi reassembly; • platelet activation; • positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway; • membrane organization; • GO:0072468 signal transduction; • protein targeting; • regulation of cell death; • cytokine-mediated signaling pathway; • regulation of synapse maturation; • synaptic target recognition;
	Sources:Amigo / QuickGO
Orthologau
	7534
	n/a
	ENSG00000164924
	n/a
	P63104
	n/a
NM_001135699; NM_001135700; NM_001135701; NM_001135702; NM_003406;
	NM_145690
	n/a
NP_001129171; NP_001129172; NP_001129173; NP_001129174; NP_003397;
	NP_663723
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn YWHAZ yw YWHAZ a elwir hefyd yn 14-3-3 protein zeta/delta (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 8, band 8q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YWHAZ.

HEL4
YWHAD
KCIP-1
HEL-S-3
HEL-S-93
14-3-3-zeta

Llyfryddiaeth

"Prognostic significance of YWHAZ expression in localized prostate cancer. ". Prostate Cancer Prostatic Dis. 2014. PMID 25156059.
"Increased 14-3-3ζ expression in the multidrug-resistant leukemia cell line HL-60/VCR as compared to the parental line mediates cell growth and apoptosis in part through modification of gene expression. ". Acta Haematol. 2014. PMID 24603438.
"14-3-3ζ silencing retards tongue squamous cell carcinoma progression by inhibiting cell survival and migration. ". Cancer Gene Ther. 2016. PMID 27080223.
"14-3-3-zeta participates in TLR3-mediated TICAM-1 signal-platform formation. ". Mol Immunol. 2016. PMID 27058640.
"Down-regulation of 14-3-3 Zeta Inhibits TGF-β1-Induced Actomyosin Contraction in Human Trabecular Meshwork Cells Through RhoA Signaling Pathway.". Invest Ophthalmol Vis Sci. 2016. PMID 26906158.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] YWHAZ - Cronfa NCBI

[1]

[2]