YY1

YY1
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	1UBD, 1ZNM, 4C5I
Dynodwyr
Cyfenwau	YY1, DELTA, INO80S, NF-E1, UCRBP, YIN-YANG-1, YY1 transcription factor, GADEVS
Dynodwyr allanol	OMIM: 600013 HomoloGene: 2556 GeneCards: YY1
Patrwm RNA pattern
	; ;
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • GO:0001106 transcription corepressor activity; • GO:0001105 transcription coactivator activity; • zinc ion binding; • metal ion binding; • GO:0001948, GO:0016582 protein binding; • four-way junction DNA binding; • GO:0001158 cis-regulatory region sequence-specific DNA binding; • RNA binding; • nucleic acid binding; • SMAD binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • sequence-specific DNA binding; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific; • histone deacetylase binding;
Cydrannau o'r gell	• Ino80 complex; • nuclear matrix; • cnewyllyn cell; • nucleoplasm; • transcription regulator complex; • cytoplasm; • PcG protein complex;
Prosesau biolegol	• cell differentiation; • DNA recombination; • GO:0009373 regulation of transcription, DNA-templated; • GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II; • cellular response to UV; • negative regulation of gene expression; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • double-strand break repair via homologous recombination; • spermatogenesis; • GO:0100026 DNA repair; • protein deubiquitination; • negative regulation of interferon-beta production; • GO:1901227 negative regulation of transcription by RNA polymerase II; • RNA localization; • anterior/posterior pattern specification; • response to UV-C; • GO:1901313 positive regulation of gene expression; • response to prostaglandin F; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II; • camera-type eye morphogenesis; • GO:0051312, GO:0007083 chromosome organization; • cellular response to interleukin-1; • negative regulation of pri-miRNA transcription by RNA polymerase II; • negative regulation of cell growth involved in cardiac muscle cell development;
	Sources:Amigo / QuickGO
Orthologau
	7528
	n/a
	ENSG00000100811
	n/a
	P25490
	n/a
	NM_003403
	n/a
	NP_003394
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn YY1 yw YY1 a elwir hefyd yn YY1 transcription factor a Transcriptional repressor protein YY1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 14, band 14q32.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn YY1.

DELTA
NF-E1
UCRBP
GADEVS
INO80S
YIN-YANG-1

Llyfryddiaeth

"Significance of the pathogenic mutation T372R in the Yin Yang 1 protein interaction with DNA--thermodynamic studies. ". FEBS Lett. 2016. PMID 26910132.
"Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma. ". J Pathol. 2016. PMID 26800240.
"YY1 Is a Structural Regulator of Enhancer-Promoter Loops. ". Cell. 2017. PMID 29224777.
"YY1 Haploinsufficiency Causes an Intellectual Disability Syndrome Featuring Transcriptional and Chromatin Dysfunction. ". Am J Hum Genet. 2017. PMID 28575647.
"The zinc fingers of YY1 bind single-stranded RNA with low sequence specificity.". Nucleic Acids Res. 2016. PMID 27369384.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] YY1 - Cronfa NCBI

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[2]