ZAP70

ZAP70
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	4XZ0, 1FBV, 1M61, 1U59, 2CBL, 2OQ1, 2OZO, 2Y1N, 3ZNI, 4A4B, 4A4C, 4K2R, 4XZ1
Dynodwyr
Cyfenwau	ZAP70, SRK, STCD, STD, TZK, ZAP-70, zeta chain of T cell receptor associated protein kinase 70kDa, zeta chain of T cell receptor associated protein kinase 70, zeta chain of T-cell receptor associated protein kinase 70, IMD48, ADMIO2
Dynodwyr allanol	OMIM: 176947 HomoloGene: 839 GeneCards: ZAP70
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• transferase activity; • nucleotide binding; • protein kinase activity; • non-membrane spanning protein tyrosine kinase activity; • kinase activity; • GO:0001948, GO:0016582 protein binding; • protein tyrosine kinase activity; • signaling receptor binding; • ATP binding; • phosphotyrosine residue binding;
Cydrannau o'r gell	• cytoplasm; • cytosol; • bilen; • cell-cell junction; • extrinsic component of cytoplasmic side of plasma membrane; • Cellbilen; • T cell receptor complex; • immunological synapse; • membrane raft;
Prosesau biolegol	• positive regulation of T cell differentiation; • T cell migration; • positive regulation of calcium-mediated signaling; • GO:0007243 intracellular signal transduction; • adaptive immune response; • phosphorylation; • transmembrane receptor protein tyrosine kinase signaling pathway; • immune system process; • T cell aggregation; • beta selection; • negative thymic T cell selection; • protein phosphorylation; • B cell activation; • T cell differentiation; • GO:0046730, GO:0046737, GO:0046738, GO:0046736 immune response; • positive thymic T cell selection; • peptidyl-tyrosine autophosphorylation; • protein autophosphorylation; • peptidyl-tyrosine phosphorylation; • innate immune response; • T cell receptor signaling pathway; • thymic T cell selection; • positive regulation of alpha-beta T cell differentiation; • T cell activation; • regulation of cell population proliferation; • positive regulation of alpha-beta T cell proliferation;
	Sources:Amigo / QuickGO
Orthologau
	7535
	n/a
	ENSG00000115085
	n/a
	P43403
	n/a
	NM_001079; NM_207519; NM_001378594
	n/a
	NP_001070; NP_997402; NP_001365523
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZAP70 yw ZAP70 a elwir hefyd yn Zeta chain of T-cell receptor associated protein kinase 70 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 2, band 2q11.2.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZAP70.

SRK
STD
TZK
STCD
IMD48
ADMIO2
ZAP-70

Llyfryddiaeth

"Novel compound heterozygous mutations in ZAP70 in a Chinese patient with leaky severe combined immunodeficiency disorder. ". Immunogenetics. 2017. PMID 28124082.
"An electrostatic selection mechanism controls sequential kinase signaling downstream of the T cell receptor. ". Elife. 2016. PMID 27700984.
"The role of ZAP70 kinase in acute lymphoblastic leukemia infiltration into the central nervous system. ". Haematologica. 2017. PMID 27686375.
"Imaging Spatiotemporal Activities of ZAP-70 in Live T Cells Using a FRET-Based Biosensor. ". Ann Biomed Eng. 2016. PMID 27384937.
"SH2 Domains Serve as Lipid-Binding Modules for pTyr-Signaling Proteins.". Mol Cell. 2016. PMID 27052731.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ZAP70 - Cronfa NCBI

[1]

[2]