ZFHX3

ZFHX3
Strwythurau
PDB	Human UniProt search: PDBe RCSB
Rhestr o ddynodwyr PDB
	2DA1, 2DA2, 2DA3
Dynodwyr
Cyfenwau	ZFHX3, ATBF1, ATBT, ZNF927, zinc finger homeobox 3
Dynodwyr allanol	OMIM: 104155 HomoloGene: 21366 GeneCards: ZFHX3
Patrwm RNA pattern
	Rhagor o gyfeiriadau
Ontoleg y genyn
Gweithrediad moleciwlaidd	• DNA binding; • sequence-specific DNA binding; • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity; • zinc ion binding; • metal ion binding; • core promoter sequence-specific DNA binding; • GO:0001948, GO:0016582 protein binding; • nucleic acid binding; • enzyme binding; • transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding; • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding; • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific; • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific;
Cydrannau o'r gell	• cytoplasm; • nuclear body; • transcription regulator complex; • cnewyllyn cell; • nucleoplasm;
Prosesau biolegol	• negative regulation of myoblast differentiation; • GO:0009373 regulation of transcription, DNA-templated; • regulation of locomotor rhythm; • muscle organ development; • transcription by RNA polymerase II; • circadian regulation of gene expression; • transcription, DNA-templated; • GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated; • positive regulation of myoblast differentiation; • GO:0045996 negative regulation of transcription, DNA-templated; • response to transforming growth factor beta; • GO:1901227 negative regulation of transcription by RNA polymerase II; • brain development; • regulation of neuron differentiation; • positive regulation of cell adhesion; • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologau
	463
	n/a
	ENSG00000140836
	n/a
	Q15911
	n/a
	NM_001164766; NM_006885
	n/a
	NP_001158238; NP_008816
	n/a
	Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn ZFHX3 yw ZFHX3 a elwir hefyd yn Zinc finger homeobox 3 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn ôl o gromosom dynol 16, band 16q22.2-q22.3.^[2]

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn ZFHX3.

ATBT
ATBF1
ZNF927

Llyfryddiaeth

"Cellular localization of ATBF1 protein and its functional implication in breast epithelial cells. ". Biochem Biophys Res Commun. 2017. PMID 28624455.
"Association of ZFHX3 gene variation with atrial fibrillation, cerebral infarction, and lung thromboembolism: An autopsy study. ". J Cardiol. 2017. PMID 28007413.
"A diagnostic marker for superficial urothelial bladder carcinoma: lack of nuclear ATBF1 (ZFHX3) by immunohistochemistry suggests malignant progression. ". BMC Cancer. 2016. PMID 27756245.
"Zinc Finger Homeodomain Factor Zfhx3 Is Essential for Mammary Lactogenic Differentiation by Maintaining Prolactin Signaling Activity. ". J Biol Chem. 2016. PMID 27129249.
"Rs7193343 polymorphism in zinc finger homeobox 3 (ZFHX3) gene and atrial fibrillation: an updated meta-analysis of 10 case-control comparisons.". BMC Cardiovasc Disord. 2015. PMID 26112950.

Cyfeiriadau

[1] "Human PubMed Reference:".

[2] ZFHX3 - Cronfa NCBI

[1]

[2]