Receptor de calcitonina

Receptor de Calcitonina
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolo CALCR (HGNC: 1440)
Identificadores
externos
Locus Cr. 7 [1]
Ortólogos
Especies
Humano Ratón
Entrez
799
UniProt
P30988 n/a
[editar datos en Wikidata]
CALCR
Estructuras disponibles
PDB Buscar ortólogos: PDBe, RCSB
Identificadores
Símbolos CALCR (HGNC: 1440) CRT, CT-R, CTR, CTR1
Identificadores
externos
Locus Cr. 7 q21.3
Ortólogos
Especies
Humano Ratón
Entrez
799 n/a
Ensembl
Véase HS n/a
UniProt
P30988 > -->
RefSeq
(ARNm)
NM_001742 n/a
RefSeq
(proteína) NCBI
NP_001158209 n/a
Ubicación (UCSC)
Cr. 7:
93.42 – 93.57 Mb 		n/a
PubMed (Búsqueda)
[2]


[editar datos en Wikidata]

El receptor de calcitonina (CTR en inglés) es un receptor acoplado a proteínas G al que se une la hormona peptídica calcitonina y participa en el mantenimiento de la homeostasis del calcio,[1]​ particularmente con respecto a la formación ósea y el metabolismo.[2]​[3]​[4]​

La CT funciona activando las proteínas G Gs y Gq que a menudo se encuentran en los osteoclastos, en las células del riñón y en las células de varias regiones del cerebro.[5]​ También puede afectar los ovarios en las mujeres y los testículos en los hombres.

La función de la proteína del receptor CT se modifica a través de su interacción con las proteínas modificadoras de la actividad del receptor(RAMPs), formando los receptores de amilina multimérica AMY1 (CT + RAMP1), AMY2 (CT + RAMP2), y AMY3 (CT + RAMP3).[6]​

Interacciones

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Se ha demostrado que el receptor de calcitonina interactúa con la apolipoproteína B[7]​[8]​ y LRP1.[9]​

Referencias

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  1. ↑ Purdue BW, Tilakaratne N, Sexton PM. (2002). «Molecular pharmacology of the calcitonin receptor». Receptors & Channels 8 (3-4): 243-255. PMID 12529940. doi:10.1080/10606820213681. 
  2. ↑ Chambers T.J., Magnus C.J. (January 1982). «Calcitonin alters behaviour of isolated osteoclasts». The Journal of Pathology 136 (1): 27-39. PMID 7057295. doi:10.1002/path.1711360104. 
  3. ↑ Dacquin R, Davey R.A., Laplace C, Levasseur R, Morris HA, Goldring SR, Gebre-Medhin S, Galson DL, Zajac JD, Karsenty G (February 2004). «Amylin inhibits bone resorption while the calcitonin receptor controls bone formation in vivo». The Journal of Cell Biology 164 (4): 509-14. PMC 2171986. PMID 14970190. doi:10.1083/jcb.200312135. 
  4. ↑ Davey RA, Turner AG, McManus JF, Maria Chiu WSM, Tjahyono F, Moore AJ, Atkins GJ, Anderson PH, Ma C., Glatt V, MacLean HE, Vincent C, Bouxsein M, Morris HA, Findlay DM, Zajac JD (August 2008). «Calcitonin receptor plays a physiological role to protect against hypercalcemia in mice». Journal of Bone and Mineral Research 23 (8): 1182-93. PMC 2680171. PMID 18627265. doi:10.1359/jbmr.080310. 
  5. ↑ «senselab». Archivado desde el original el 28 de febrero de 2009. Consultado el 20 de abril de 2019. 
  6. ↑ «Calcitonin Receptors: Introduction». IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archivado desde el original el 3 de marzo de 2016. 
  7. ↑ Zhang J, Herscovitz H. (February 2003). «Nascent lipidated apolipoprotein B is transported to the Golgi as an incompletely folded intermediate as probed by its association with network of endoplasmic reticulum molecular chaperones, GRP94, ERp72, BiP, calreticulin, and cyclophilin B». The Journal of Biological Chemistry 278 (9): 7459-68. PMID 12397072. doi:10.1074/jbc.M207976200. 
  8. ↑ Linnik KM, Herscovitz H. (August 1998). «Multiple molecular chaperones interact with apolipoprotein B during its maturation. The network of endoplasmic reticulum-resident chaperones (ERp72, GRP94, calreticulin, and BiP) interacts with apolipoprotein b regardless of its lipidation state». The Journal of Biological Chemistry 273 (33): 21368-73. PMID 9694898. doi:10.1074/jbc.273.33.21368. 
  9. ↑ Anthony Wayne Orr, Claudio E. Pedraza, Manuel Antonio Pallero, Carrie A. Elzie, Silvia Goicoechea, Dudley K. Strickland,Joanne E. Murphy-Ullrich (June 2003). «Low density lipoprotein receptor-related protein is a calreticulin coreceptor that signals focal adhesion disassembly». The Journal of Cell Biology 161 (6): 1179-89. PMC 2172996. PMID 12821648. doi:10.1083/jcb.200302069. 

Lecturas adicionales

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  • Pondel M (December 2000). «Calcitonin and calcitonin receptors: bone and beyond». International Journal of Experimental Pathology 81 (6): 405-22. PMC 2517743. PMID 11298188. doi:10.1046/j.1365-2613.2000.00176.x. 
  • Gorn AH, Lin HY, Yamin M, Auron PE, Flannery MR, Tapp DR, Manning CA, Lodish HF, Krane SM, Goldring SR (November 1992). «Cloning, characterization, and expression of a human calcitonin receptor from an ovarian carcinoma cell line». The Journal of Clinical Investigation 90 (5): 1726-35. PMC 443230. PMID 1331173. doi:10.1172/JCI116046. 
  • Albrandt K, Brady EM, Moore CX, Mull E, Sierzega ME, Beaumont K (December 1995). «Molecular cloning and functional expression of a third isoform of the human calcitonin receptor and partial characterization of the calcitonin receptor gene». Endocrinology 136 (12): 5377-84. PMID 7588285. doi:10.1210/en.136.12.5377. 
  • Egerton M, Needham M, Evans S, Millest A, Cerillo G, McPheat J, Popplewell M, Johnstone D, Hollis M (April 1995). «Identification of multiple human calcitonin receptor isoforms: heterologous expression and pharmacological characterization». Journal of Molecular Endocrinology 14 (2): 179-89. PMID 7619207. doi:10.1677/jme.0.0140179. 
  • Nussenzveig DR, Mathew S, Gershengorn MC (May 1995). «Alternative splicing of a 48-nucleotide exon generates two isoforms of the human calcitonin receptor». Endocrinology 136 (5): 2047-51. PMID 7720653. doi:10.1210/en.136.5.2047. 
  • Nakamura M, Hashimoto T, Nakajima T, Ichii S, Furuyama J, Ishihara Y, Kakudo K (April 1995). «A new type of human calcitonin receptor isoform generated by alternative splicing». Biochemical and Biophysical Research Communications 209 (2): 744-51. PMID 7733946. doi:10.1006/bbrc.1995.1562. 
  • Pérez Jurado LA, Li X, Francke U (1995). «The human calcitonin receptor gene (CALCR) at 7q21.3 is outside the deletion associated with the Williams syndrome». Cytogenetics and Cell Genetics 70 (3-4): 246-9. PMID 7789182. doi:10.1159/000134044. 
  • Nussenzveig DR, Thaw CN, Gershengorn MC (November 1994). «Inhibition of inositol phosphate second messenger formation by intracellular loop one of a human calcitonin receptor. Expression and mutational analysis of synthetic receptor genes». The Journal of Biological Chemistry 269 (45): 28123-9. PMID 7961748. 
  • Kuestner RE, Elrod RD, Grant FJ, Hagen FS, Kuijper JL, Matthewes SL, O'Hara PJ, Sheppard PO, Stroop SD, Thompson DL (August 1994). «Cloning and characterization of an abundant subtype of the human calcitonin receptor». Molecular Pharmacology 46 (2): 246-55. PMID 8078488. 
  • Frendo JL, Pichaud F, Mourroux RD, Bouizar Z, Segond N, Moukhtar MS, Jullienne A (April 1994). «An isoform of the human calcitonin receptor is expressed in TT cells and in medullary carcinoma of the thyroid». FEBS Letters 342 (2): 214-6. PMID 8143880. doi:10.1016/0014-5793(94)80503-2. 
  • Masi L, Becherini L, Gennari L, Colli E, Mansani R, Falchetti A, Cepollaro C, Gonnelli S, Tanini A, Brandi ML (April 1998). «Allelic variants of human calcitonin receptor: distribution and association with bone mass in postmenopausal Italian women». Biochemical and Biophysical Research Communications 245 (2): 622-6. PMID 9571205. doi:10.1006/bbrc.1998.8445. 
  • Taboulet J, Frenkian M, Frendo JL, Feingold N, Jullienne A, de Vernejoul MC (December 1998). «Calcitonin receptor polymorphism is associated with a decreased fracture risk in post-menopausal women». Human Molecular Genetics 7 (13): 2129-33. PMID 9817931. doi:10.1093/hmg/7.13.2129. 
  • Christopoulos G, Perry KJ, Morfis M, Tilakaratne N, Gao Y, Fraser NJ, Main MJ, Foord SM, Sexton PM (July 1999). «Multiple amylin receptors arise from receptor activity-modifying protein interaction with the calcitonin receptor gene product». Molecular Pharmacology 56 (1): 235-42. PMID 10385705. 
  • Nishikawa T, Ishikawa H, Yamamoto S, Koshihara Y (September 1999). «A novel calcitonin receptor gene in human osteoclasts from normal bone marrow». FEBS Letters 458 (3): 409-14. PMID 10570950. doi:10.1016/S0014-5793(99)01176-X. 
  • Beaudreuil J, Taboulet J, Orcel P, Graulet AM, Denne MA, Baudoin C, Jullienne A, De Vernejoul MC (July 2000). «Calcitonin receptor mRNA in mononuclear leucocytes from postmenopausal women: decrease during osteoporosis and link to bone markers with specific isoform involvement». Bone 27 (1): 161-8. PMID 10865224. doi:10.1016/S8756-3282(00)00305-7. 
  • Wada S, Yasuda S, Nagai T, Maeda T, Kitahama S, Suda S, Findlay DM, Iitaka M, Katayama S (April 2001). «Regulation of calcitonin receptor by glucocorticoid in human osteoclast-like cells prepared in vitro using receptor activator of nuclear factor-kappaB ligand and macrophage colony-stimulating factor». Endocrinology 142 (4): 1471-8. PMID 11250927. doi:10.1210/en.142.4.1471. 
  • Ogden CA, deCathelineau A, Hoffmann PR, Bratton D, Ghebrehiwet B, Fadok VA, Henson PM (September 2001). «C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells». The Journal of Experimental Medicine 194 (6): 781-95. PMC 2195958. PMID 11560994. doi:10.1084/jem.194.6.781. 
  • Nosaka Y, Tachi Y, Shimpuku H, Kawamura T, Ohura K (2002). «Association of calcitonin receptor gene polymorphism with early marginal bone loss around endosseous implants». The International Journal of Oral & Maxillofacial Implants 17 (1): 38-43. PMID 11858573. 
  • Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA (December 2002). «Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences». Proceedings of the National Academy of Sciences of the United States of America 99 (26): 16899-903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899. 

Enlaces externos

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  • «Calcitonin Receptors». IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Consultado el 5 de diciembre de 2023.