CYP2C8

CYP2C8
Egitura erabilgarria PDB Ortologoaren bilaketa: PDBe RCSB PDB ID kodeen zerrenda 2VN0, 1PQ2, 2NNH, 2NNI, 2NNJ
Identifikatzaileak
Aliasak	CYP2C8 (HUGO), CPC8, CYPIIC8, MP-12/MP-20, cytochrome P450 family 2 subfamily C member 8, CYP2C8DM
Kanpoko IDak	OMIM: 601129   MGI: 1306818   HomoloGene: 117948   GeneCards: CYP2C8   OMA: CYP2C8 - orthologs
Genetikoki lotutako gaixotasunak
Baztanga, osteonecrosis  [1]
Drogaren xedea
phenelzine  [2]
Genearen kokapena (gizakia) Kromosoma: 10 (gizakia)[3] Banda 10q23.33 Hasiera 95.036.772 bp[3] Amaiera 95.069.497 bp[3]
Genearen kokapena (sagua) Kromosoma: 19 (sagua)[4] Banda 19|19 C3 Hasiera 39.499.306 bp[4] Amaiera 39.556.973 bp[4]
RNA adierazpen eredua Bgee gizakia sagua (ortholog) Adierazpen ohikoena right lobe of liver  esperma  pancreatic ductal cell  right uterine tube  Barrabil behazun xixku adenohipofisi left adrenal cortex  Gonada body of stomach  Adierazpen ohikoena gibel Diafragma Erreferentziazko adierazpen datu gehiago BioGPS Erreferentziazko adierazpen datu gehiago
Gene ontologia Funtzio molekularra oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen  caffeine oxidase activity  aromatase activity  oxidoreductase activity  heme binding  metal ion binding  iron ion binding  arachidonic acid epoxygenase activity  monooxygenase activity  estrogen 16-alpha-hydroxylase activity  steroid hydroxylase activity  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen  Zelularen osagaia Erretikulu endoplasmatiko  organelle membrane  mintza  intracellular membrane-bounded organelle  endoplasmic reticulum membrane  zitoplasma  Prozesu biologikoa omega-hydroxylase P450 pathway  organic acid metabolic process  epoxygenase P450 pathway  oxidative demethylation  xenobiotic metabolic process  lipid hydroxylation  steroid metabolic process  long-chain fatty acid biosynthetic process  estrogen metabolic process  Iturburuak: : Amigo / QuickGO
Ortologoak Espeziea Gizakia Sagua Entrez 1558 13098 Ensembl ENSG00000138115 ENSMUSG00000025003 UniProt P10632 P56656 RefSeq (RNAm) NM_000770 NM_001198853 NM_001198854 NM_001198855 NM_030878 NM_010003 NM_001373937 RefSeq (proteina) NP_000761 NP_001185782 NP_001185783 NP_001185784 NP_034133 NP_001360866 Kokapena (UCSC) Chr 10: 95.04 – 95.07 Mb Chr 19: 39.5 – 39.56 Mb PubMed bilaketa [5] [6]
Wikidata
Ikusi/Editatu giza genea Ikusi/Editatu saguaren genea

P450 2C8 zitokromoa (CYP2C8) P450 zitokromoaren proteina-multzoko entzima da. Entzima horrek zerikusia du, besteak beste, paclitaxel, repaglinida, rosiglitazona eta zeribastatina botiken metabolismoan. Lehen, "P450 zitokromoa, IIC subfamilia (mefenitoina 4-hidroxilasa), 8 polipeptidoa" deitzen zitzaion.^[7]

CYP2C8aren inhibitzaileak

Identifikaturiko inhibitzaile indartsuena leukotrieno-hartzailearen antagonista izan zen, montelukast. CYP2C8aren beste inhibitzaile batzuk klase terapeutiko ugariren bidez identifikatu ziren, klase bakar bat nagusitu gabe. Inhibitzaile indartsu horien artean daude candesartan zilexetiloa (txirristako profarmakoa), zafirlukast, clotrimazola, felodipinoa eta mometasonaren furoatoa.^[8]

Erreferentziak

1. Genetikoki lotutako gaixotasunak CYP2C8ikusi/editatu erreferentziak Wikidatan. .
2. Fisikoki elkarreragiten duten drogak cytochrome P450 family 2 subfamily C member 8ikusi/editatu erreferentziak Wikidatan. .
3. ↑ GRCh38: Ensembl release 89: ENSG00000138115 - Ensembl, May 2017
4. ↑ GRCm38: Ensembl release 89: ENSMUSG00000025003 – Ensembl, May 2017
5. Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
6. Mouse PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine.
7. genenames.org. CYP2C8. .
8. Walsky, RL; Gaman EA; Obach RS.. (Jan de 2005). «Examination of 209 drugs for inhibition of cytochrome P450 2C8.» J. Clin. Pharmacol 45 (1): 68..

Kanpo estekak