Etoposido

Etoposido
Formula kimikoa	C29H32O13
SMILES kanonikoa	2D eredua
SMILES isomerikoa	C[C@@H]1OC[C@@H]2[C@@H](O1)[C@@H]([C@H]([C@@H](O2)O[C@H]3[C@H]4COC(=O)[C@@H]4[C@@H](C5=CC6=C(C=C35)OCO6)C7=CC(=C(C(=C7)OC)O)OC)O)O
MolView	3D eredua
Mota	[[(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aR,8aR,9R)-5-[(7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl)oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] ^(en) eta [[(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one|(8aR,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-isobenzofuro[6,5-f][1,3]benzodioxol-8-one]] ^(en)
Estereoisomeroa	[[(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one|(5S,5aS,8aS,9R)-5-[[(2R,4aR,6R,7R,8R,8aS)-7,8-dihydroxy-2-methyl-4,4a,6,7,8,8a-hexahydropyrano[3,2-d][1,3]dioxin-6-yl]oxy]-9-(4-hydroxy-3,5-dimethoxyphenyl)-5a,6,8a,9-tetrahydro-5H-[2]benzofuro[6,5-f][1,3]benzodioxol-8-one]] ^(en)
Masa molekularra	588,184 Da
Erabilera
Konposatu aktiboa	Toposar ^(en) eta Etopophos ^(en)
Tratatzen du	Neuroblastoma, testicular cancer ^(en) , garuneko minbizi, mikosi fungoide, trophoblastic neoplasm ^(en) , Ewingen sarkoma, histiozitosi, lung benign neoplasm ^(en) , prostatako minbizi, umetokiko minbizi, Kaposiren sarkoma, acute myeloid leukemia ^(en) , errabdomiosarkoma, maxkuriko minbizi, linfoma, germ cell cancer ^(en) , B-cell lymphoma ^(en) , ez-Hodgkin linfoma, testicular malignant germ cell cancer ^(en) , Hezur sarkoma, neuroblastoma, susceptibility to ^(en) , diffuse large B-cell lymphoma ^(en) , testicular cancer ^(en) eta lung small cell carcinoma ^(en)
Interakzioak	ziklosporina
Elkarrekintza	DNA topoisomerase II alpha ^(en)
Hartzeko bidea	intravenous infusion and defusion ^(en) eta aho emate
Haurdunaldia	Australian pregnancy category D ^(en) eta US pregnancy category D ^(en)
Rola	DNA polymerase inhibitors ^(en) , topoisomerase inhibitor ^(en) , phytogenic antineoplastic agents ^(en) , topoisomerase II inhibitor ^(en) , developmental toxicant ^(en) , kantzerigeno eta farmako esentzial
Identifikatzaileak
InChlKey	VJJPUSNTGOMMGY-MRVIYFEKSA-N
CAS zenbakia	33419-42-0
ChemSpider	33510
PubChem	36462
Gmelin	4911
ChEMBL	CHEMBL44657
EC zenbakia	251-509-1
ECHA	100.046.812
MeSH	D005047
RxNorm	4179
Human Metabolome Database	HMDB0014911
UNII	6PLQ3CP4P3
NDF-RT	N0000146478
KEGG	C01576 eta D00125
PDB Ligand	EVP

Ohar medikoa

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Etoposidoa, VP-16 bezala ere ezaguna, podofilina erdiintetiko bat da, Podophyllum landaretik eratorria. Tumore-zelulen ugalketa inhibitzeko duen gaitasunagatik minbizi mota batzuk tratatzeko erabiltzen dute.

Banaketa azkarreko zelula osasuntsu batzuetan ere eragin dezake, hala nola odolaren, digestio-aparatuaren edo ilearen zeluletan, eta, beraz, albo-ondorio kaltegarriak ere sortzen ditu.

Etoposidoa 1983an merkaturatu zuten.^[1]

Erreferentziak

1. (Ingelesez) Fischer, Janos; Ganellin, C. Robin. (2006). Analogue-based Drug Discovery. John Wiley & Sons, 489 or. ISBN 9783527607495..

Kanpo estekak

Artikulu hau kimikari buruzko zirriborroa da. Wikipedia lagun dezakezu edukia osatuz.