گیرنده ۱ پلی‌پپتید پانکراسی

NPY4R
معین‌کننده‌ها
نام‌های دیگر	NPY4R, NPY4-R, PP1, PPYR1, Y4, Pancreatic polypeptide receptor 1, neuropeptide Y receptor Y4
شناسه‌های بیرونی	OMIM: 601790 MGI: 105374 HomoloGene: 116086 GeneCards: NPY4R
موقعیت ژن (موش) کروموزوم کروموزوم ۱۴ (موش)[۱] نوار 14 B|14 20.8 cM شروع 33,865,949 bp[۱] پایان 33,874,446 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • neuropeptide Y receptor activity • G protein-coupled receptor activity • signal transducer activity • pancreatic polypeptide receptor activity • peptide hormone binding ترکیبات سلولی • integral component of membrane • پوسته یاخته • integral component of plasma membrane • membrane فرایند زیستی • GO:0072468 ورارسانی پیام • neuropeptide signaling pathway • chemical synaptic transmission • G protein-coupled receptor signaling pathway منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	5540	19065
آنسامبل	ENSG00000204174	ENSMUSG00000048337
یونی‌پروت	P0DQD5 P50391	Q61041
RefSeq (mRNA)	NM_005972، XM_011539936، XM_011539937، XM_017016386، XM_017016387، XR_001747124، XR_007061972 NM_001278794، NM_005972، XM_011539936، XM_011539937، XM_017016386، XM_017016387، XR_001747124، XR_007061972	NM_008919
RefSeq (پروتئین)	XP_005277701، XP_006717608، XP_011537416، XP_011537417، XP_016870952، XP_016870953 NP_001265724، XP_005277701، XP_006717608، XP_011537416، XP_011537417، XP_016870952، XP_016870953 NP_005963، XP_011538238، XP_011538239، XP_016871875، XP_016871876، NP_001265724، XP_005277701، XP_006717608، XP_011537417، XP_016870952، XP_016870953 NP_001265723، NP_005963، XP_011538238، XP_011538239، XP_016871875، XP_016871876، NP_001265724، XP_005277701، XP_006717608، XP_011537417، XP_016870952، XP_016870953	NP_032945
موقعیت (UCSC)	ن/م	Chr : 33.87 – 33.87 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

گیرنده ۱ پلی‌پپتید پانکراسی که به عنوان گیرنده نوروپپتید Y نوع ۴ نیز شناخته می‌شود، پروتئینی است که در انسان توسط ژن PPYR1 کدگذاری می‌شود.^[۴][۵]

لیگاندهای انتخابی

آگونیست‌ها

• پلی‌پپتید پانکراسی
• نوروپپتید Y (آگونیست درون زاد، غیر انتخابی زیرگروه)
• پپتید YY
• GR-231,118 (آنتاگونیست مخلوط NPY ₁ / آگونیست NPY ₄، CAS# 158859-98-4)

آنتاگونیست‌ها

• UR-AK49^[۶]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000048337 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Lutz CM, Richards JE, Scott KL, Sinha S, Yang-Feng TL, Frankel WN, Thompson DA (Dec 1997). "Neuropeptide Y receptor genes mapped in human and mouse: receptors with high affinity for pancreatic polypeptide are not clustered with receptors specific for neuropeptide Y and peptide YY". Genomics. 46 (2): 287–90. doi:10.1006/geno.1997.5024. PMID 9417917.
5. "Entrez Gene: PPYR1 pancreatic polypeptide receptor 1".
6. Ziemek R, Schneider E, Kraus A, Cabrele C, Beck-Sickinger AG, Bernhardt G, Buschauer A (2007). "Determination of affinity and activity of ligands at the human neuropeptide Y Y4 receptor by flow cytometry and aequorin luminescence". Journal of Receptor and Signal Transduction Research. 27 (4): 217–33. doi:10.1080/10799890701505206. PMID 17885919.

پیوند به بیرون

• "Neuropeptide Y Receptors: Y₄". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.

جهت مطالعه

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• Kawabe T, Muslin AJ, Korsmeyer SJ (Jan 1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
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