AKT2 ساختارهای موجود PDB جستجوی همساختشناسی: PDBe RCSB فهرست شناسههای PDB 1GZK , 1GZN , 1GZO , 1MRV , 1MRY , 1O6K , 1O6L , 1P6S , 2JDO , 2JDR , 2UW9 , 2X39 , 2XH5 , 3D0E , 3E87 , 3E88 , 3E8D
معینکنندهها نامهای دیگر AKT2 , v-akt murine thymoma viral oncogene homolog 2, HIHGHH, PKBB, PKBBETA, PRKBB, RAC-BETA, AKT serine/threonine kinase 2شناسههای بیرونی OMIM: 164731 MGI: 104874 HomoloGene: 48773 GeneCards: AKT2 همساختشناسی گونهها انسان موش Entrez آنسامبل یونیپروت RefSeq (mRNA) RefSeq (پروتئین) موقعیت (UCSC) ن/م Chr : 27.29 – 27.34 Mb جستجوی PubMed [ ۲] [ ۳] ویکیداده
پروتئین کیناز اختصاصی سرین/ترئونین RAC-بتا (انگلیسی : RAC-beta serine/threonine-protein kinase )[ ۴] یک آنزیم است که در انسان توسط ژن «AKT2 » کُدگذاری میشود.[ ۵] این پروتئین به عنوان جزئی از مسیر ترارسانی پیام انسولین بر ذخیرهسازی متابولیتها اثر میگذارد.[ ۴]
بیان بیش از حد این ژن باعث ایجاد نوع تهاجمی تر سرطان لوزالمعده میگردد.[ ۶]
موشهایی که این پروتئین را ندارند، دچار دیابت شدید میشوند و این امر نشاندهنده نقش این مولکول در ترارسانی پیام از گیرندههای انسولین است. این موشها همچنین در صورت ابتلا به سرطان پستان ، پیشآگهی بدتری دارند.[ ۷]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000004056 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ ۴٫۰ ۴٫۱ Tsoukas, Michael A.; Mantzoros, Christos S. (2016-01-01), Jameson, J. Larry; De Groot, Leslie J; de Kretser, David M.; Giudice, Linda C. (eds.), "Chapter 37 - Lipodystrophy Syndromes" , Endocrinology: Adult and Pediatric (Seventh Edition) (به انگلیسی), Philadelphia: W.B. Saunders, pp. 648–661.e5, doi :10.1016/b978-0-323-18907-1.00037-8 , ISBN 978-0-323-18907-1 , retrieved 2020-12-18
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↑ "Entrez Gene: AKT2 v-akt murine thymoma viral oncogene homolog 2" .
↑ Heron-Milhavet L, Khouya N, Fernandez A, Lamb NJ (2011). "Akt1 and Akt2: differentiating the aktion". Histol. Histopathol . 26 (5): 651–62. PMID 21432781 .
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