CD19

CD19
معین‌کننده‌ها
نام‌های دیگر	CD19, B4, CVID3, CD19 molecule
شناسه‌های بیرونی	OMIM: 107265 MGI: 88319 HomoloGene: 1341 GeneCards: CD19
موقعیت ژن (موش) کروموزوم کروموزوم ۷ (موش)[۱] نوار 7 F3|7 69.01 cM شروع 126,007,622 bp[۱] پایان 126,014,061 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0001948، GO:0016582 پیوند پروتئینی • phosphatidylinositol-4,5-bisphosphate 3-kinase activity ترکیبات سلولی • integral component of membrane • پوسته یاخته • integral component of plasma membrane • extracellular exosome • membrane • external side of plasma membrane • GO:0009327 protein-containing complex • لیپید رفت فرایند زیستی • cellular defense response • cell surface receptor signaling pathway • regulation of immune response • positive regulation of release of sequestered calcium ion into cytosol • phosphatidylinositol phosphate biosynthetic process • B cell receptor signaling pathway • regulation of complement activation • positive regulation of protein kinase B signaling • B-1 B cell differentiation • B cell proliferation involved in immune response • immunoglobulin mediated immune response • B cell mediated immunity • positive regulation of phosphatidylinositol 3-kinase activity • antigen receptor-mediated signaling pathway • regulation of B cell receptor signaling pathway • regulation of B cell activation • adaptive immune response • immune system process منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	930	12478
آنسامبل	ENSG00000177455	ENSMUSG00000030724
یونی‌پروت	P15391	P25918
RefSeq (mRNA)	NM_001770، XM_011545981، XR_950871، NM_001385732، NR_169755 NM_001178098، NM_001770، XM_011545981، XR_950871، NM_001385732، NR_169755	NM_001357091، XM_030242041، XM_036152614، XM_036152615 NM_009844، NM_001357091، XM_030242041، XM_036152614، XM_036152615
RefSeq (پروتئین)	NP_001761، XP_006721166، XP_011544283، XP_016879382 NP_001171569، NP_001761، XP_006721166، XP_011544283، XP_016879382	NP_001344020، XP_030097901، XP_036008507، XP_036008508 NP_033974، NP_001344020، XP_030097901، XP_036008507، XP_036008508
موقعیت (UCSC)	ن/م	Chr : 126.01 – 126.01 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

مجموعه تمایزی ۱۹ (انگلیسی: Cluster of Differentiation 19) یا به‌اختصار «CD19» که به نام «آنتی‌ژن CD19 لنفوسیت بی» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «CD19» کُد می‌شود.^[۴][۵]

این مولکول پروتئینی در سطح لنفوسیت‌های بی و «سلول‌های دندریتی فولیکولار» یافت می‌شود و از آن در تشخیص لنفوم‌های سلول B استفاده می‌شود.^[۶]

جهش در این پروتئین موجب بروز سندرم‌های نقص ایمنی شدید می‌شود که مشخصه‌شان، کاهش تولید آنتی‌بادی است.^[۷][۸]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000030724 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CD19 CD19 molecule".
5. Tedder TF, Isaacs CM (Jul 1989). "Isolation of cDNAs encoding the CD19 antigen of human and mouse B lymphocytes. A new member of the immunoglobulin superfamily". Journal of Immunology. 143 (2): 712–7. PMID 2472450.
6. Scheuermann RH, Racila E (Aug 1995). "CD19 antigen in leukemia and lymphoma diagnosis and immunotherapy". Leukemia & Lymphoma. 18 (5–6): 385–97. doi:10.3109/10428199509059636. PMID 8528044.
7. Pesando JM, Bouchard LS, McMaster BE (Dec 1989). "CD19 is functionally and physically associated with surface immunoglobulin". The Journal of Experimental Medicine. 170 (6): 2159–64. doi:10.1084/jem.170.6.2159. PMC 2189531. PMID 2479707.
8. van Zelm MC, Reisli I, van der Burg M, Castaño D, van Noesel CJ, van Tol MJ, Woellner C, Grimbacher B, Patiño PJ, van Dongen JJ, Franco JL (May 2006). "An antibody-deficiency syndrome due to mutations in the CD19 gene". The New England Journal of Medicine. 354 (18): 1901–12. doi:10.1056/NEJMoa051568. PMID 16672701.

• مشارکت‌کنندگان ویکی‌پدیا. «CD19». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ دسامبر ۲۰۱۷.

بیشتر بخوانید

• Goldsby, Richard A.; Kindt, Thomas J.; Osborne, Barbara A. (2006). Kuby Immunology. San Francisco: W. H. Freeman. ISBN 0-7167-8590-0.
• Ishikawa H, Tsuyama N, Mahmoud MS, Fujii R, Abroun S, Liu S, Li FJ, Kawano MM (Mar 2002). "CD19 expression and growth inhibition of tumours in human multiple myeloma". Leukemia & Lymphoma. 43 (3): 613–6. doi:10.1080/10428190290012146. PMID 12002767.
• Zhou LJ, Ord DC, Omori SA, Tedder TF (1992). "Structure of the genes encoding the CD19 antigen of human and mouse B lymphocytes". Immunogenetics. 35 (2): 102–11. doi:10.1007/BF00189519. PMID 1370948.
• Carter RH, Fearon DT (Apr 1992). "CD19: lowering the threshold for antigen receptor stimulation of B lymphocytes". Science. 256 (5053): 105–7. doi:10.1126/science.1373518. PMID 1373518.
• Kozmik Z, Wang S, Dörfler P, Adams B, Busslinger M (Jun 1992). "The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP". Molecular and Cellular Biology. 12 (6): 2662–72. doi:10.1128/mcb.12.6.2662. PMC 364460. PMID 1375324.
• Bradbury LE, Kansas GS, Levy S, Evans RL, Tedder TF (Nov 1992). "The CD19/CD21 signal transducing complex of human B lymphocytes includes the target of antiproliferative antibody-1 and Leu-13 molecules". Journal of Immunology. 149 (9): 2841–50. PMID 1383329.
• Matsumoto AK, Kopicky-Burd J, Carter RH, Tuveson DA, Tedder TF, Fearon DT (Jan 1991). "Intersection of the complement and immune systems: a signal transduction complex of the B lymphocyte-containing complement receptor type 2 and CD19". The Journal of Experimental Medicine. 173 (1): 55–64. doi:10.1084/jem.173.1.55. PMC 2118751. PMID 1702139.
• Zhou LJ, Ord DC, Hughes AL, Tedder TF (Aug 1991). "Structure and domain organization of the CD19 antigen of human, mouse, and guinea pig B lymphocytes. Conservation of the extensive cytoplasmic domain". Journal of Immunology. 147 (4): 1424–32. PMID 1714482.
• Stamenkovic I, Seed B (Sep 1988). "CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail". The Journal of Experimental Medicine. 168 (3): 1205–10. doi:10.1084/jem.168.3.1205. PMC 2189043. PMID 2459292.
• Ord DC, Edelhoff S, Dushkin H, Zhou LJ, Beier DR, Disteche C, Tedder TF (1994). "CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7". Immunogenetics. 39 (5): 322–8. doi:10.1007/BF00189228. PMID 7513297.
• Weng WK, Jarvis L, LeBien TW (Dec 1994). "Signaling through CD19 activates Vav/mitogen-activated protein kinase pathway and induces formation of a CD19/Vav/phosphatidylinositol 3-kinase complex in human B cell precursors". The Journal of Biological Chemistry. 269 (51): 32514–21. PMID 7528218.
• Myers DE, Jun X, Waddick KG, Forsyth C, Chelstrom LM, Gunther RL, Tumer NE, Bolen J, Uckun FM (Oct 1995). "Membrane-associated CD19-LYN complex is an endogenous p53-independent and Bc1-2-independent regulator of apoptosis in human B-lineage lymphoma cells". Proceedings of the National Academy of Sciences of the United States of America. 92 (21): 9575–9. doi:10.1073/pnas.92.21.9575. PMC 40844. PMID 7568175.
• Chalupny NJ, Aruffo A, Esselstyn JM, Chan PY, Bajorath J, Blake J, Gilliland LK, Ledbetter JA, Tepper MA (Oct 1995). "Specific binding of Fyn and phosphatidylinositol 3-kinase to the B cell surface glycoprotein CD19 through their src homology 2 domains". European Journal of Immunology. 25 (10): 2978–84. doi:10.1002/eji.1830251040. PMID 7589101.
• Tuscano JM, Engel P, Tedder TF, Agarwal A, Kehrl JH (Jun 1996). "Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22". European Journal of Immunology. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID 8647200.
• Carter RH, Doody GM, Bolen JB, Fearon DT (Apr 1997). "Membrane IgM-induced tyrosine phosphorylation of CD19 requires a CD19 domain that mediates association with components of the B cell antigen receptor complex". Journal of Immunology. 158 (7): 3062–9. PMID 9120258.
• Husson H, Mograbi B, Schmid-Antomarchi H, Fischer S, Rossi B (May 1997). "CSF-1 stimulation induces the formation of a multiprotein complex including CSF-1 receptor, c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene. 14 (19): 2331–8. doi:10.1038/sj.onc.1201074. PMID 9178909.
• Khine AA, Firtel M, Lingwood CA (Aug 1998). "CD77-dependent retrograde transport of CD19 to the nuclear membrane: functional relationship between CD77 and CD19 during germinal center B-cell apoptosis". Journal of Cellular Physiology. 176 (2): 281–92. doi:10.1002/(SICI)1097-4652(199808)176:2<281::AID-JCP6>3.0.CO;2-K. PMID 9648915.
• Thunberg U, Gidlöf C, Bånghagen M, Sällström JF, Sundström C, Tötterman T (1998). "HpaII polymerase chain reaction restriction fragment length polymorphism in the human CD19 gene on 16p11". Human Heredity. 48 (4): 230–1. doi:10.1159/000022806. PMID 9694255.
• Horváth G, Serru V, Clay D, Billard M, Boucheix C, Rubinstein E (Nov 1998). "CD19 is linked to the integrin-associated tetraspans CD9, CD81, and CD82". The Journal of Biological Chemistry. 273 (46): 30537–43. doi:10.1074/jbc.273.46.30537. PMID 9804823.
• Buhl AM, Cambier JC (Apr 1999). "Phosphorylation of CD19 Y484 and Y515, and linked activation of phosphatidylinositol 3-kinase, are required for B cell antigen receptor-mediated activation of Bruton's tyrosine kinase". Journal of Immunology. 162 (8): 4438–46. PMID 10201980.

پیوند به بیرون

• مکان ژنوم CD19 انسانی و صفحهٔ جزئیات ژنی CD19 در سامانه جستجوی بانک ژنی دانشگاه کالیفرنیا، سانتا کروز.