HDAC1

HDAC1
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 4BKX, 5ICN
معین‌کننده‌ها
نام‌های دیگر	HDAC1, GON-10, HD1, RPD3, RPD3L1, histone deacetylase 1, KDAC1
شناسه‌های بیرونی	OMIM: 601241 MGI: 108086 HomoloGene: 68426 GeneCards: HDAC1
موقعیت ژن (موش) کروموزوم کروموزوم ۴ (موش)[۱] نوار 4 D2.2|4 63.26 cM شروع 129,409,897 bp[۱] پایان 129,436,506 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • NAD-dependent histone deacetylase activity (H3-K14 specific) • GO:0001106 transcription corepressor activity • histone deacetylase activity • protein N-terminus binding • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • protein deacetylase activity • histone deacetylase binding • GO:0000975 transcription cis-regulatory region binding • NF-kappaB binding • deacetylase activity • GO:0001948، GO:0016582 پیوند پروتئینی • nucleosomal DNA binding • enzyme binding • hydrolase activity • core promoter sequence-specific DNA binding • p53 binding • transcription factor binding • RNA polymerase II core promoter sequence-specific DNA binding • DNA binding • chromatin binding • Krueppel-associated box domain binding • E-box binding • promoter-specific chromatin binding ترکیبات سلولی • سیتوپلاسم • NuRD complex • سیتوزول • histone deacetylase complex • Sin3 complex • نوکلئوپلاسم • هسته یاخته • کروماتین • GO:0035328 هتروکروماتین • transcription regulator complex • transcription repressor complex • GO:0009327 protein-containing complex • soma • Sin3-type complex فرایند زیستی • hair follicle placode formation • epidermal cell differentiation • chromatin remodeling • GO:0009373 regulation of transcription, DNA-templated • rhythmic process • negative regulation of androgen receptor signaling pathway • embryonic digit morphogenesis • negative regulation of apoptotic process • انعقاد خون • GO:1901227 negative regulation of transcription by RNA polymerase II • eyelid development in camera-type eye • circadian regulation of gene expression • negative regulation of gene expression • GO:0060469، GO:0009371 positive regulation of transcription, DNA-templated • odontogenesis of dentin-containing tooth • protein deacetylation • histone H4 deacetylation • fungiform papilla formation • negative regulation of myotube differentiation • GO:0022415 viral process • histone deacetylation • negative regulation of canonical Wnt signaling pathway • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II • transcription, DNA-templated • regulation of signal transduction by p53 class mediator • DNA methylation-dependent heterochromatin assembly • beta-catenin-TCF complex assembly • GO:0031497، GO:0006336، GO:0034724، GO:0001301، GO:0007580، GO:0034652، GO:0010847 chromatin organization • positive regulation of cell population proliferation • GO:0045996 negative regulation of transcription, DNA-templated • histone H3 deacetylation • regulation of megakaryocyte differentiation • GO:0044324، GO:0003256، GO:1901213، GO:0046019، GO:0046020، GO:1900094، GO:0061216، GO:0060994، GO:1902064، GO:0003258، GO:0072212 regulation of transcription by RNA polymerase II • endoderm development • ساعت زیستی • hippocampus development • neuron differentiation • negative regulation of I-kappaB kinase/NF-kappaB signaling • positive regulation of oligodendrocyte differentiation • regulation of endopeptidase activity • regulation of amyloid-beta clearance • negative regulation of intrinsic apoptotic signaling pathway منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	3065	433759
آنسامبل	ENSG00000116478	ENSMUSG00000028800
یونی‌پروت	Q13547	O09106
RefSeq (mRNA)	NM_004964 XM_011541309، NM_004964	NM_008228
RefSeq (پروتئین)	XP_011539611 NP_004955، XP_011539611	NP_032254
موقعیت (UCSC)	ن/م	Chr : 129.41 – 129.44 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

هیستون دِاَستیلاز ۱ (انگلیسی: Histone deacetylase 1) یک پروتئین است که در انسان توسط ژن «HDAC1» کُدگذاری می‌شود.^[۴]

این پروتئین نقش بسیار مهمی در تنظیم رونویسی ژن‌ها، پیشرفتِ چرخهٔ سلولی و وقایع تکاملی سلول دارد.

این پروتئین در دِاستیله کردنِ پروتئین پی۵۳ و تعدیل اثر آن بر روی رشد سلول و آپوپتوز نقش دارد.^[۵]

تعامل مولکولی

این پروتئین با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

• گیرنده آندروژن^[۶]
• CDH1^[۷]
• CTBP1^{[۸][۹][۱۰]}
• GATA1^[۱۱]
• HDAC2 ^{[۱۲][۱۳][۱۴][۱۵][۱۶][۱۷][۱۸][۱۹][۲۰][۲۱][۲۲][۲۳][۲۴]}
• SMAD2^[۲۵]
• پروتئین لوسمی پرومیلوسیتیک^[۲۶][۲۷]
• SIN3A^{[۱۲][۲۸][۱۳][۲۹][۲۲][۲۳][۳۰][۳۱][۳۲][۳۳][۳۴][۳۵][۳۶][۳۷]}
• فاکتور رونویسی Sp1^{[۳۳][۳۸][۳۹][۴۰]}
• ZBTB16^{[۴۱][۴۲][۴۳]}

جستارهای وابسته

• هیستون داستیلاز

منابع

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• مشارکت‌کنندگان ویکی‌پدیا. «HDAC1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ مارس ۲۰۲۰.

برای مطالعهٔ بیشتر

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پیون به بیرون

• HDAC1 protein, human در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا