MAP1LC3A

MAP1LC3A
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 3ECI, 3WAL, 3WAN, 4ZDV
معین‌کننده‌ها
نام‌های دیگر	MAP1LC3A, ATG8E, LC3, LC3A, MAP1ALC3, MAP1BLC3, microtubule associated protein 1 light chain 3 alpha
شناسه‌های بیرونی	OMIM: 601242 MGI: 1915661 HomoloGene: 12021 GeneCards: MAP1LC3A
موقعیت ژن (موش) کروموزوم کروموزوم ۲ (موش)[۱] نوار 2|2 H1 شروع 155,118,217 bp[۱] پایان 155,119,993 bp[۱]
هستی‌شناسی ژن عملکرد ملکولی • phosphatidylethanolamine binding • GO:0001948، GO:0016582 پیوند پروتئینی • phospholipid binding • ubiquitin protein ligase binding • microtubule binding ترکیبات سلولی • سیتوپلاسم • organelle membrane • سیتوزول • late endosome • membrane • autophagosome • ریزلوله • اسکلت سلولی • GO:0016023 cytoplasmic vesicle • دستگاه غشایی درونی • autolysosome • autophagosome membrane • سیناپس فرایند زیستی • خودخواری • میتوفاژی • autophagosome assembly • response to iron(II) ion • response to lead ion • response to nutrient levels • cellular response to amino acid starvation • response to morphine • cellular response to hydrogen peroxide • cellular response to copper ion • cellular response to nitrogen starvation • cellular response to starvation • macroautophagy • GO:0000046 autophagosome maturation منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	84557	66734
آنسامبل	ENSG00000101460	ENSMUSG00000027602
یونی‌پروت	Q9H492	Q91VR7
RefSeq (mRNA)	NM_032514، NM_181509، XM_011529084، XM_047440558، XM_047440559 XM_011529085، NM_032514، NM_181509، XM_011529084، XM_047440558، XM_047440559	NR_046364 NM_025735، NR_046364
RefSeq (پروتئین)	NP_852610، XP_011527385، XP_011527386، XP_011527387 NP_115903، NP_852610، XP_011527385، XP_011527386، XP_011527387	NP_080011
موقعیت (UCSC)	ن/م	Chr : 155.12 – 155.12 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

زنجیرهٔ سبک ۳اِی پروتئین‌های 1A/1B مرتبط با ریزلوله (انگلیسی: Microtubule-associated proteins 1A/1B light chain 3A) یک پروتئین است که در انسان توسط ژن «MAP1LC3A» کُدگذاری می‌شود.^[۴][۵][۶] این پروتئین یکی از اجزاء اسکلت سلولی است و همچنین یک زیست‌نشانگر اتوفاژی محسوب می‌شود.^[۷]

این پروتئین با سکئوستوزوم ۱ تعامل پروتئین-پروتئین دارد.^[۸]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000027602 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Mann SS, Hammarback JA (May 1997). "Gene localization and developmental expression of light chain 3: a common subunit of microtubule-associated protein 1A(MAP1A) and MAP1B". J Neurosci Res. 43 (5): 535–44. doi:10.1002/(SICI)1097-4547(19960301)43:5<535::AID-JNR3>3.0.CO;2-J. PMID 8833088. S2CID 23515321.
5. Pankiv S, Clausen TH, Lamark T, Brech A, Bruun JA, Outzen H, Overvatn A, Bjorkoy G, Johansen T (Aug 2007). "p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy". J Biol Chem. 282 (33): 24131–45. doi:10.1074/jbc.M702824200. PMID 17580304.
6. "Entrez Gene: MAP1LC3A microtubule-associated protein 1 light chain 3 alpha".
7. Valente G, Morani F, Nicotra G, Fusco N, Peracchio C, Titone R, Alabiso O, Arisio R, Katsaros D, Benedetto C, Isidoro C (2014). "Expression and clinical significance of the autophagy proteins BECLIN 1 and LC3 in ovarian cancer". Biomed Res Int. 2014: 462658. doi:10.1155/2014/462658. PMC 4127242. PMID 25136588.
8. Shvets E, Fass E, Scherz-Shouval R, Elazar Z (August 2008). "The N-terminus and Phe52 residue of LC3 recruit p62/SQSTM1 into autophagosomes". J. Cell Sci. 121 (Pt 16): 2685–95. doi:10.1242/jcs.026005. PMID 18653543.

برای مطالعهٔ بیشتر

• Snásel J, Pichová I (1997). "The cleavage of host cell proteins by HIV-1 protease". Folia Biol. (Praha). 42 (5): 227–30. doi:10.1007/BF02818986. PMID 8997639. S2CID 7617882.
• Wallin M, Deinum J, Goobar L, Danielson UH (1990). "Proteolytic cleavage of microtubule-associated proteins by retroviral proteinases". J. Gen. Virol. 71 (9): 1985–91. doi:10.1099/0022-1317-71-9-1985. PMID 2212989.
• Schoenfeld TA, McKerracher L, Obar R, Vallee RB (1989). "MAP 1A and MAP 1B are structurally related microtubule associated proteins with distinct developmental patterns in the CNS". J. Neurosci. 9 (5): 1712–30. doi:10.1523/JNEUROSCI.09-05-01712.1989. PMC 6569839. PMID 2470876.
• Mann SS, Hammarback JA (1994). "Molecular characterization of light chain 3. A microtubule binding subunit of MAP1A and MAP1B". J. Biol. Chem. 269 (15): 11492–7. doi:10.1016/S0021-9258(19)78150-2. PMID 7908909.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
• Bonnet C, Boucher D, Lazereg S, et al. (2001). "Differential binding regulation of microtubule-associated proteins MAP1A, MAP1B, and MAP2 by tubulin polyglutamylation". J. Biol. Chem. 276 (16): 12839–48. doi:10.1074/jbc.M011380200. PMID 11278895.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• He H, Dang Y, Dai F, et al. (2003). "Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B". J. Biol. Chem. 278 (31): 29278–87. doi:10.1074/jbc.M303800200. PMID 12740394.
• Tanida I, Sou YS, Ezaki J, et al. (2004). "HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates". J. Biol. Chem. 279 (35): 36268–76. doi:10.1074/jbc.M401461200. PMID 15187094.
• Kouno T, Mizuguchi M, Tanida I, et al. (2005). "1H, 13C, and 15N resonance assignments of human microtubule-associated protein light chain-3". J. Biomol. NMR. 29 (3): 415–6. doi:10.1023/B:JNMR.0000032505.99071.ea. PMID 15213446. S2CID 23561733.
• Goehler H, Lalowski M, Stelzl U, et al. (2004). "A protein interaction network links GIT1, an enhancer of huntingtin aggregation, to Huntington's disease". Mol. Cell. 15 (6): 853–65. doi:10.1016/j.molcel.2004.09.016. PMID 15383276.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Kouno T, Mizuguchi M, Tanida I, et al. (2005). "Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains". J. Biol. Chem. 280 (26): 24610–7. doi:10.1074/jbc.M413565200. PMID 15857831.
• Sou YS, Tanida I, Komatsu M, et al. (2006). "Phosphatidylserine in addition to phosphatidylethanolamine is an in vitro target of the mammalian Atg8 modifiers, LC3, GABARAP, and GATE-16". J. Biol. Chem. 281 (6): 3017–24. doi:10.1074/jbc.M505888200. PMID 16303767.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.