MAPKAPK2 ساختارهای موجود PDB جستجوی همساختشناسی: PDBe RCSB فهرست شناسههای PDB 1KWP , 1NXK , 1NY3 , 2JBO , 2JBP , 2OKR , 2ONL , 2OZA , 2P3G , 2PZY , 3A2C , 3FPM , 3FYJ , 3FYK , 3GOK , 3KA0 , 3KC3 , 3KGA , 3M2W , 3M42 , 3R2B , 3R2Y , 3R30 , 3WI6 , 4TYH
معینکنندهها نامهای دیگر MAPKAPK2 , MAPKAP-K2, MK-2, MK2, mitogen-activated protein kinase-activated protein kinase 2, MAPK activated protein kinase 2شناسههای بیرونی OMIM: 602006 MGI: 109298 HomoloGene: 56412 GeneCards: MAPKAPK2 همساختشناسی گونهها انسان موش Entrez آنسامبل یونیپروت RefSeq (mRNA) RefSeq (پروتئین) موقعیت (UCSC) ن/م Chr : 130.98 – 131.03 Mb جستجوی PubMed [ ۲] [ ۳] ویکیداده
پروتئین کیناز ۲ فعال شده توسط MAP کیناز (انگلیسی : MAPKAPK2 ) یک پروتئین است که در انسان توسط ژن «MAPKAPK2 » کُدگذاری میشود و جزئی از خانوادهٔ پروتئین کیناز اختصاصی سرین/ترئونین است.[ ۴] [ ۵] [ ۶]
این پروتئین یکی از میانجیهای آغاز فعالیت فاکتورهای فنوتیپ ترشحی مرتبط با پیری (SASP) توسط MTOR است.[ ۷] [ ۸] فعالیت MTOR سطح اینترلوکین ۱ آلفا را افزایش میدهد و اینکار با واسطهٔ MAPKAPK2 انجام میشود.[ ۹]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000016528 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ Zu YL, Wu F, Gilchrist A, Ai Y, Labadia ME, Huang CK (April 1994). "The primary structure of a human MAP kinase activated protein kinase 2". Biochemical and Biophysical Research Communications . 200 (2): 1118–24. doi :10.1006/bbrc.1994.1566 . PMID 8179591 .
↑ Stokoe D, Caudwell B, Cohen PT, Cohen P (December 1993). "The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2" . The Biochemical Journal . 296 ( Pt 3) (Pt 3): 843–9. doi :10.1042/bj2960843 . PMC 1137771 . PMID 8280084 .
↑ Liu T, Warburton RR, Hill NS, Kayyali US (August 2015). "Anthrax lethal toxin-induced lung injury and treatment by activating MK2" . Journal of Applied Physiology . 119 (4): 412–9. doi :10.1152/japplphysiol.00335.2015 . PMC 4538279 . PMID 26066827 .
↑ Yessenkyzy A, Saliev T, Zhanaliyeva M, Masoud AR, Umbayev B, Sergazy S, et al. (May 2020). "Polyphenols as Caloric-Restriction Mimetics and Autophagy Inducers in Aging Research" . Nutrients . 12 (5): 1344. doi :10.3390/nu12051344 . PMC 7285205 . PMID 32397145 .
↑ Papadopoli D, Boulay K, Kazak L, Pollak M, Mallette F, Topisirovic I, Hulea L (2019). "mTOR as a central regulator of lifespan and aging" . F1000Research . 8 : 998. doi :10.12688/f1000research.17196.1 . PMC 6611156 . PMID 31316753 .
↑ Laberge RM, Sun Y, Orjalo AV, Patil CK, Freund A, Zhou L, et al. (August 2015). "MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation" . Nature Cell Biology . 17 (8): 1049–61. doi :10.1038/ncb3195 . PMC 4691706 . PMID 26147250 .
Kapopara PR, von Felden J, Soehnlein O, Wang Y, Napp LC, Sonnenschein K, et al. (December 2014). "Deficiency of MAPK-activated protein kinase 2 (MK2) prevents adverse remodelling and promotes endothelial healing after arterial injury". Thrombosis and Haemostasis . 112 (6): 1264–76. doi :10.1160/TH14-02-0174 . PMID 25120198 .
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Lavoie JN, Lambert H, Hickey E, Weber LA, Landry J (January 1995). "Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27" . Molecular and Cellular Biology . 15 (1): 505–16. doi :10.1128/MCB.15.1.505 . PMC 232001 . PMID 7799959 .
Sutherland C, Alterio J, Campbell DG, Le Bourdellès B, Mallet J, Haavik J, Cohen P (October 1993). "Phosphorylation and activation of human tyrosine hydroxylase in vitro by mitogen-activated protein (MAP) kinase and MAP-kinase-activated kinases 1 and 2" . European Journal of Biochemistry . 217 (2): 715–22. doi :10.1111/j.1432-1033.1993.tb18297.x . PMID 7901013 .
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Rivera VM, Miranti CK, Misra RP, Ginty DD, Chen RH, Blenis J, Greenberg ME (October 1993). "A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity" . Molecular and Cellular Biology . 13 (10): 6260–73. doi :10.1128/mcb.13.10.6260 . PMC 364685 . PMID 8413226 .
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Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P (December 1995). "Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2" . The EMBO Journal . 14 (23): 5920–30. doi :10.1002/j.1460-2075.1995.tb00280.x . PMC 394711 . PMID 8846784 .
Tan Y, Rouse J, Zhang A, Cariati S, Cohen P, Comb MJ (September 1996). "FGF and stress regulate CREB and ATF-1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2" . The EMBO Journal . 15 (17): 4629–42. doi :10.1002/j.1460-2075.1996.tb00840.x . PMC 452194 . PMID 8887554 .
Huang CK, Zhan L, Ai Y, Jongstra J (January 1997). "LSP1 is the major substrate for mitogen-activated protein kinase-activated protein kinase 2 in human neutrophils" . The Journal of Biological Chemistry . 272 (1): 17–9. doi :10.1074/jbc.272.1.17 . PMID 8995217 .
Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S (January 1997). "Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils" . The Journal of Biological Chemistry . 272 (2): 937–44. doi :10.1074/jbc.272.2.937 . PMID 8995385 .
Engel K, Kotlyarov A, Gaestel M (June 1998). "Leptomycin B-sensitive nuclear export of MAPKAP kinase 2 is regulated by phosphorylation" . The EMBO Journal . 17 (12): 3363–71. doi :10.1093/emboj/17.12.3363 . PMC 1170674 . PMID 9628873 .
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فعالیت قواعد دستهبندی سینتیک انواع
نگارخانه PDB
1kwp : ساختار کریستالی مولکول
MAPKAPK2
1nxk : ساختار کریستالی استراسپورین متصل به KAP کیناز ۲
1ny3 : ساختار کریستالی ADP متصل به MAP KAP کیناز ۲
2jbo : پروتئین کیناز MK2 در ترکیب با یک بازدارنده (شکل کریستالی ۱، آغشتهشده)
2jbp : پروتئین کیناز MK2 در ترکیب با یک بازدارنده (شکل کریستالی ۲، در حالی کریستالی شدن)
2onl : ساختار کریستالی هترودایمر p38a-MAPKAP کیناز ۲
2oza : ساختار کمپلکس ترکیبی پی۳۸آلفا