NR2F1 معینکنندهها نامهای دیگر NR2F1 , BBOAS, BBSOAS, COUP-TFI, EAR-3, EAR3, ERBAL3, NR2F2, SVP44, TCFCOUP1, TFCOUP1, nuclear receptor subfamily 2 group F member 1, COUPTF1شناسههای بیرونی OMIM: 132890 MGI: 1352451 HomoloGene: 21158 GeneCards: NR2F1 همساختشناسی گونهها انسان موش Entrez آنسامبل یونیپروت RefSeq (mRNA) RefSeq (پروتئین) موقعیت (UCSC) ن/م Chr : 78.34 – 78.35 Mb جستجوی PubMed [ ۲] [ ۳] ویکیداده
فاکتور رونویسی پروموتر بالادست اوآلبومین مرغ (انگلیسی : Chicken Ovalbumin Upstream Promoter Transcription Factor ) با نام اختصاری COUP-TF1 که بیشتر با نام «زیرخانوادهٔ ۲ گیرندههای هستهای، گروه اف، عضو ۱» (انگلیسی : N uclear R eceptor subfamily 2 , group F , member 1 ) یا NR2F1 شناخته میشود، یک پروتئین است که در انسان توسط ژن «NR2F1 » کُدگذاری میشود.[ ۴] [ ۵] این پروتئین، عضوی از خانوادهٔ گیرندههای هستهای هورمونهای استروئیدی است.
این فاکتورِ رونویسی به پروموتر اوآلبومین متصل شده و در کنار یک پروتئین دیگر به نام اس ۳۰۰–۲ ، رونویسی ژنی را تحریک میکند.[ ۶] [ ۷] پروتئین NR2F1 میتواند، هم به توالیهای مستقیم و هم به توالیهای قرینه (پالیندروم) موتیف 5'-AGGTCA-3' اتصال یابد.[ ۸]
این پروتئین با مولکولهای زیر تعامل پروتئین-پروتئین دارد:
جهش در ژن «NR2F1 » با بروز بیماری ژنتیکی سندرم آتروفی عصب بینایی بوش-بونسترا-شاف مرتبط است.[ ۱۲]
↑ ۱٫۰ ۱٫۱ ۱٫۲ GRCm38: Ensembl release 89: ENSMUSG00000069171 - Ensembl , May 2017
↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .
↑ "Entrez Gene: NR2F1 nuclear receptor subfamily 2, group F, member 1" .
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↑ Tsai SY, Tsai MJ (Apr 1997). "Chick ovalbumin upstream promoter-transcription factors (COUP-TFs): coming of age". Endocrine Reviews . 18 (2): 229–40. doi :10.1210/er.18.2.229 . PMID 9101138 .
↑ ۹٫۰ ۹٫۱ Avram D, Fields A, Pretty On Top K, Nevrivy DJ, Ishmael JE, Leid M (Apr 2000). "Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors" . The Journal of Biological Chemistry . 275 (14): 10315–22. doi :10.1074/jbc.275.14.10315 . PMC 2819356 . PMID 10744719 .
↑ Dressel U, Thormeyer D, Altincicek B, Paululat A, Eggert M, Schneider S, Tenbaum SP, Renkawitz R, Baniahmad A (May 1999). "Alien, a highly conserved protein with characteristics of a corepressor for members of the nuclear hormone receptor superfamily" . Molecular and Cellular Biology . 19 (5): 3383–94. doi :10.1128/mcb.19.5.3383 . PMC 84131 . PMID 10207062 .
↑ Métivier R, Gay FA, Hübner MR, Flouriot G, Salbert G, Gannon F, Kah O, Pakdel F (Jul 2002). "Formation of an hER alpha-COUP-TFI complex enhances hER alpha AF-1 through Ser118 phosphorylation by MAPK" . The EMBO Journal . 21 (13): 3443–53. doi :10.1093/emboj/cdf344 . PMC 126093 . PMID 12093745 .
↑ Hobbs MM, Wolters WC, Rayapati AO (2020) Bosch-Boonstra-Schaaf optic atrophy syndrome presenting as new-onset psychosis in a 32-year-old man: A case report and literature review. J Psychiatr Pract 26(1):58-62
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