PPP2R1A

PPP2R1A
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1B3U, 2IE3, 2IE4, 2NPP, 2NYL, 2NYM, 2PKG, 3C5W, 3DW8, 3K7V, 3K7W, 4I5L, 4I5N, 4LAC,%%s2IE4, 2NPP, 2IE3, 3K7V, 3K7W
معین‌کننده‌ها
نام‌های دیگر	PPP2R1A, PP2A-Aalpha, PP2AAALPHA, PR65A, MRD36, protein phosphatase 2 scaffold subunit Aalpha, PP2AA
شناسه‌های بیرونی	OMIM: 605983 MGI: 1926334 HomoloGene: 68559 GeneCards: PPP2R1A
موقعیت ژن (موش) کروموزوم کروموزوم ۱۷ (موش)[۱] نوار 17|17 A3.2 شروع 21,165,573 bp[۱] پایان 21,186,178 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • protein serine/threonine phosphatase activity • GO:0001948، GO:0016582 پیوند پروتئینی • protein heterodimerization activity • protein phosphatase regulator activity • protein antigen binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • microtubule cytoskeleton • protein phosphatase type 2A complex • کروموزوم • میتوکندری • میان‌پار • extracellular exosome • هسته یاخته • پوسته یاخته • membrane • lateral plasma membrane • دندریت • cell projection • سیناپس • glutamatergic synapse فرایند زیستی • GO:0097285 مرگ برنامه‌ریزی‌شده یاخته • regulation of meiotic cell cycle process involved in oocyte maturation • meiotic sister chromatid cohesion, centromeric • GO:0009373 regulation of transcription, DNA-templated • ceramide metabolic process • regulation of DNA replication • chromosome segregation • GO:0016576 protein dephosphorylation • meiotic spindle elongation • female meiotic nuclear division • response to organic substance • positive regulation of extrinsic apoptotic signaling pathway in absence of ligand • peptidyl-serine dephosphorylation • regulation of Wnt signaling pathway • regulation of cell adhesion • G2/M transition of mitotic cell cycle • negative regulation of cell growth • پیرایش آران‌ای • regulation of cell differentiation • regulation of growth • mitotic nuclear membrane reassembly • mitotic sister chromatid separation • nuclear-transcribed mRNA catabolic process, nonsense-mediated decay • second-messenger-mediated signaling • ciliary basal body-plasma membrane docking • negative regulation of tyrosine phosphorylation of STAT protein • regulation of G2/M transition of mitotic cell cycle • regulation of phosphoprotein phosphatase activity • GO:0034622 protein-containing complex assembly منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	5518	51792
آنسامبل	ENSG00000105568	ENSMUSG00000007564
یونی‌پروت	P30153	Q76MZ3
RefSeq (mRNA)	NM_014225، NM_001363656 NR_033500، NM_014225، NM_001363656	NM_016891
RefSeq (پروتئین)	NP_001350585 NP_055040، NP_001350585 NP_055040.2	NP_058587
موقعیت (UCSC)	ن/م	Chr : 21.17 – 21.19 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

پروتئین پروتئاز 2A سرین/ترئونین ۶۵ کیلودالتونی تنظیم‌کننده، زیرواحد A ایزوفرم آلفا (انگلیسی: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform) یک آنزیم است که در انسان توسط ژن «PPP2R1A» کُدگذاری می‌شود.^[۴] این ژن زیرواحد زیرواحد A از ایزوفرم آلفایِ تنظیم‌کننده ثابت پروتئین فسفاتاز ۲ را کُدگذاری می‌کند.^[۵]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000007564 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Everett AD, Xue C, Stoops T (August 1999). "Developmental expression of protein phosphatase 2A in the kidney". J. Am. Soc. Nephrol. 10 (8): 1737–45. doi:10.1681/ASN.V1081737. PMID 10446941.
5. "Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform".

برای مطالعهٔ بیشتر

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