جی‌آربی۱۰

GRB10
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 3HK0, 1NRV
معین‌کننده‌ها
نام‌های دیگر	GRB10, GRB-IR, Grb-10, IRBP, MEG1, RSS, growth factor receptor bound protein 10
شناسه‌های بیرونی	OMIM: 601523 MGI: 103232 HomoloGene: 3882 GeneCards: GRB10
موقعیت ژن (موش) کروموزوم کروموزوم ۱۱ (موش)[۱] نوار 11 A1|11 7.15 cM شروع 11,880,508 bp[۱] پایان 11,988,683 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • GO:0001948، GO:0016582 پیوند پروتئینی • insulin receptor binding • identical protein binding ترکیبات سلولی • سیتوپلاسم • سیتوزول • پوسته یاخته • GO:0009327 protein-containing complex فرایند زیستی • response to insulin • positive regulation of vascular endothelial growth factor receptor signaling pathway • negative regulation of glucose import • GO:1903105 negative regulation of insulin receptor signaling pathway • insulin-like growth factor receptor signaling pathway • negative regulation of phosphorylation • positive regulation of phosphorylation • negative regulation of glycogen biosynthetic process • GO:0072468 ورارسانی پیام • GO:1901047 insulin receptor signaling pathway • هدایت آسه • negative regulation of Wnt signaling pathway • positive regulation of cold-induced thermogenesis منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	2887	14783
آنسامبل	ENSG00000106070	ENSMUSG00000020176
یونی‌پروت	Q13322	Q60760
RefSeq (mRNA)	NM_001001550، NM_001001555، NM_005311، XM_011515316، XM_011515323، XM_017012029، XM_017012030، XM_017012031، XM_017012032، XM_017012033، XM_017012034، XM_017012036، XM_017012037، XM_017012038، XM_017012039، XM_017012040، XM_017012042، XM_017012043، XM_017012045، XM_017012046، XM_017012047، XM_017012048، XM_017012049، XM_017012050، XM_017012053، XM_017012054، XM_017012055، XM_017012056، XM_017012058، XM_017012059، XM_017012060، XM_017012061، XM_017012062، XM_017012063، XM_017012064، XM_017012065، XM_017012067، XM_017012068، NM_001350814، NM_001350815، NM_001350816، XM_024446726، XM_024446728، XM_024446729، XM_024446730، NM_001371008، NM_001371009 NM_001001549، NM_001001550، NM_001001555، NM_005311، XM_011515316، XM_011515323، XM_017012029، XM_017012030، XM_017012031، XM_017012032، XM_017012033، XM_017012034، XM_017012036، XM_017012037، XM_017012038، XM_017012039، XM_017012040، XM_017012042، XM_017012043، XM_017012045، XM_017012046، XM_017012047، XM_017012048، XM_017012049، XM_017012050، XM_017012053، XM_017012054، XM_017012055، XM_017012056، XM_017012058، XM_017012059، XM_017012060، XM_017012061، XM_017012062، XM_017012063، XM_017012064، XM_017012065، XM_017012067، XM_017012068، NM_001350814، NM_001350815، NM_001350816، XM_024446726، XM_024446728، XM_024446729، XM_024446730، NM_001371008، NM_001371009	NM_010345، XM_011243664، NM_001370603 NM_001177629، NM_010345، XM_011243664، NM_001370603
RefSeq (پروتئین)	NP_001001550، NP_001001555، XP_011513618، XP_011513625، XP_016867518، XP_016867519، XP_016867520، XP_016867521، XP_016867522، XP_016867523، XP_016867525، XP_016867526، XP_016867527، XP_016867528، XP_016867529، XP_016867531، XP_016867532، XP_016867534، XP_016867535، XP_016867536، XP_016867537، XP_016867538، XP_016867539، XP_016867542، XP_016867543، XP_016867544، XP_016867545، XP_016867547، XP_016867548، XP_016867549، XP_016867550، XP_016867551، XP_016867552، XP_016867553، XP_016867554، XP_016867556، XP_016867557، NP_001337743، NP_001337744، NP_001337745، XP_024302494، XP_024302496، XP_024302497، XP_024302498، NP_001357937، NP_001357938 NP_001001549، NP_001001550، NP_001001555، XP_011513618، XP_011513625، XP_016867518، XP_016867519، XP_016867520، XP_016867521، XP_016867522، XP_016867523، XP_016867525، XP_016867526، XP_016867527، XP_016867528، XP_016867529، XP_016867531، XP_016867532، XP_016867534، XP_016867535، XP_016867536، XP_016867537، XP_016867538، XP_016867539، XP_016867542، XP_016867543، XP_016867544، XP_016867545، XP_016867547، XP_016867548، XP_016867549، XP_016867550، XP_016867551، XP_016867552، XP_016867553، XP_016867554، XP_016867556، XP_016867557، NP_001337743، NP_001337744، NP_001337745، XP_024302494، XP_024302496، XP_024302497، XP_024302498، NP_001357937، NP_001357938	NP_034475، XP_011241966، NP_001357532 NP_001171100، NP_034475، XP_011241966، NP_001357532
موقعیت (UCSC)	ن/م	Chr : 11.88 – 11.99 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

پروتئین ۱۰ متصل به گیرندهٔ فاکتور رشد (انگلیسی: Growth factor receptor-bound protein 10) یا به اختصار «جی‌آربی۱۰»، یک پروتئین است که در انسان توسط ژن «GRB10» کُدگذاری می‌شود.^{[۴][۵][۶][۷]}

این مولکول عضوی از خانوادهٔ پروتئین‌های وفق‌دهنده ترارسانی پیام است که با تیروزین کیناز گیرنده‌ای تعامل شیمیایی دارند.

تعامل‌های شیمیایی

پروتئین جی‌آربی۱۰ با مولکول‌های زیر تعامل پروتئین-پروتئین دارد:

• ABL1^[۸][۹]
• BCR^[۸]
• C-Raf^[۱۰][۱۱]
• CD117^[۱۲]
• گیرنده انسولین^{[۹][۱۳][۱۴][۱۵][۱۶]}
• گیرنده فاکتور رشد ۱ شبه‌انسولین^{[۱۶][۱۷][۱۸][۱۹]}
• MAP2K1^[۱۱]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000020176 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: GRB10 growth factor receptor-bound protein 10".
5. Jerome CA, Scherer SW, Tsui LC, Gietz RD, Triggs-Raine B (February 1997). "Assignment of growth factor receptor-bound protein 10 (GRB10) to human chromosome 7p11.2-p12". Genomics. 40 (1): 215–6. doi:10.1006/geno.1996.4535. PMID 9070953.
6. Dong LQ, Du H, Porter SG, Kolakowski LF, Lee AV, Mandarino LJ, Fan J, Yee D, Liu F, Mandarino J (November 1997). "Cloning, chromosome localization, expression, and characterization of an Src homology 2 and pleckstrin homology domain-containing insulin receptor binding protein hGrb10gamma". J. Biol. Chem. 272 (46): 29104–12. doi:10.1074/jbc.272.46.29104. PMID 9360986.
7. Monk D, Arnaud P, Frost J, Hills FA, Stanier P, Feil R, Moore GE (August 2009). "Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression". Hum. Mol. Genet. 18 (16): 3066–74. doi:10.1093/hmg/ddp248. PMID 19487367.
8. Bai RY, Jahn T, Schrem S, Munzert G, Weidner KM, Wang JY, Duyster J (August 1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
9. Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (January 1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J Biol Chem. 272 (5): 2659–67. doi:10.1074/jbc.272.5.2659. PMID 9006901.
10. Nantel A, Huber M, Thomas DY (December 1999). "Localization of endogenous Grb10 to the mitochondria and its interaction with the mitochondrial-associated Raf-1 pool". J Biol Chem. 274 (50): 35719–24. doi:10.1074/jbc.274.50.35719. PMID 10585452.
11. Nantel A, Mohammad-Ali K, Sherk J, Posner BI, Thomas DY (April 1998). "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases". J Biol Chem. 273 (17): 10475–84. doi:10.1074/jbc.273.17.10475. PMID 9553107.
12. Jahn T, Seipel P, Urschel S, Peschel C, Duyster J (February 2002). "Role for the adaptor protein Grb10 in the activation of Akt". Mol Cell Biol. 22 (4): 979–91. doi:10.1128/MCB.22.4.979-991.2002. PMC 134632. PMID 11809791.
13. Langlais P, Dong LQ, Hu D, Liu F (June 2000). "Identification of Grb10 as a direct substrate for members of the Src tyrosine kinase family". Oncogene. 19 (25): 2895–903. doi:10.1038/sj.onc.1203616. PMID 10871840.
14. Hansen H, Svensson U, Zhu J, Laviola L, Giorgino F, Wolf G, Smith RJ, Riedel H (April 1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus". J Biol Chem. 271 (15): 8882–6. doi:10.1074/jbc.271.15.8882. PMID 8621530.
15. Liu F, Roth RA (October 1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function". Proc Natl Acad Sci U S A. 92 (22): 10287–91. Bibcode:1995PNAS...9210287L. doi:10.1073/pnas.92.22.10287. PMC 40781. PMID 7479769.
16. He W, Rose DW, Olefsky JM, Gustafson TA (March 1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". J Biol Chem. 273 (12): 6860–7. doi:10.1074/jbc.273.12.6860. PMID 9506989.
17. Vecchione A, Marchese A, Henry P, Rotin D, Morrione A (May 2003). "The Grb10/Nedd4 complex regulates ligand-induced ubiquitination and stability of the insulin-like growth factor I receptor". Mol Cell Biol. 23 (9): 3363–72. doi:10.1128/MCB.23.9.3363-3372.2003. PMC 153198. PMID 12697834.
18. Dey BR, Frick K, Lopaczynski W, Nissley SP, Furlanetto RW (June 1996). "Evidence for the direct interaction of the insulin-like growth factor I receptor with IRS-1, Shc, and Grb10". Mol Endocrinol. 10 (6): 631–41. doi:10.1210/mend.10.6.8776723. PMID 8776723.
19. Morrione A, Valentinis B, Li S, Ooi JY, Margolis B, Baserga R (July 1996). "Grb10: A new substrate of the insulin-like growth factor I receptor". Cancer Res. 56 (14): 3165–7. PMID 8764099.

برای مطالعهٔ بیشتر

• Ramírez-Dueñas ML, Medina C, Ocampo-Campos R, Rivera H (1992). "Severe Silver-Russell syndrome and translocation (17;20) (q25;q13)". Clin. Genet. 41 (1): 51–3. doi:10.1111/j.1399-0004.1992.tb03630.x. PMID 1633648. S2CID 28801507.
• Liu F, Roth RA (1995). "Grb-IR: a SH2-domain-containing protein that binds to the insulin receptor and inhibits its function". Proc. Natl. Acad. Sci. U.S.A. 92 (22): 10287–91. Bibcode:1995PNAS...9210287L. doi:10.1073/pnas.92.22.10287. PMC 40781. PMID 7479769.
• Pandey A, Duan H, Di Fiore PP, Dixit VM (1995). "The Ret receptor protein tyrosine kinase associates with the SH2-containing adapter protein Grb10". J. Biol. Chem. 270 (37): 21461–3. doi:10.1074/jbc.270.37.21461. PMID 7665556.
• Midro AT, Debek K, Sawicka A, et al. (1993). "Second observation of Silver-Russel syndrome in a carrier of a reciprocal translocation with one breakpoint at site 17q25". Clin. Genet. 44 (1): 53–5. doi:10.1111/j.1399-0004.1993.tb03845.x. PMID 8403458. S2CID 20766311.
• Hansen H, Svensson U, Zhu J, et al. (1996). "Interaction between the Grb10 SH2 domain and the insulin receptor carboxyl terminus". J. Biol. Chem. 271 (15): 8882–6. doi:10.1074/jbc.271.15.8882. PMID 8621530.
• Morrione A, Valentinis B, Li S, et al. (1996). "Grb10: A new substrate of the insulin-like growth factor I receptor". Cancer Res. 56 (14): 3165–7. PMID 8764099.
• O'Neill TJ, Rose DW, Pillay TS, et al. (1996). "Interaction of a GRB-IR splice variant (a human GRB10 homolog) with the insulin and insulin-like growth factor I receptors. Evidence for a role in mitogenic signaling". J. Biol. Chem. 271 (37): 22506–13. doi:10.1074/jbc.271.37.22506. PMID 8798417.
• Stein E, Cerretti DP, Daniel TO (1996). "Ligand activation of ELK receptor tyrosine kinase promotes its association with Grb10 and Grb2 in vascular endothelial cells". J. Biol. Chem. 271 (38): 23588–93. doi:10.1074/jbc.271.38.23588. PMID 8798570.
• Frantz JD, Giorgetti-Peraldi S, Ottinger EA, Shoelson SE (1997). "Human GRB-IRbeta/GRB10. Splice variants of an insulin and growth factor receptor-binding protein with PH and SH2 domains". J. Biol. Chem. 272 (5): 2659–67. doi:10.1074/jbc.272.5.2659. PMID 9006901.
• Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Res. 3 (5): 321–9, 341–54. doi:10.1093/dnares/3.5.321. PMID 9039502.
• He W, Rose DW, Olefsky JM, Gustafson TA (1998). "Grb10 interacts differentially with the insulin receptor, insulin-like growth factor I receptor, and epidermal growth factor receptor via the Grb10 Src homology 2 (SH2) domain and a second novel domain located between the pleckstrin homology and SH2 domains". J. Biol. Chem. 273 (12): 6860–7. doi:10.1074/jbc.273.12.6860. PMID 9506989.
• Nantel A, Mohammad-Ali K, Sherk J, et al. (1998). "Interaction of the Grb10 adapter protein with the Raf1 and MEK1 kinases". J. Biol. Chem. 273 (17): 10475–84. doi:10.1074/jbc.273.17.10475. PMID 9553107.
• Moutoussamy S, Renaudie F, Lago F, et al. (1998). "Grb10 identified as a potential regulator of growth hormone (GH) signaling by cloning of GH receptor target proteins". J. Biol. Chem. 273 (26): 15906–12. doi:10.1074/jbc.273.26.15906. PMID 9632636.
• Bai RY, Jahn T, Schrem S, et al. (1998). "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941–8. doi:10.1038/sj.onc.1202024. PMID 9747873.
• Mano H, Ohya K, Miyazato A, et al. (1998). "Grb10/GrbIR as an in vivo substrate of Tec tyrosine kinase". Genes Cells. 3 (7): 431–41. doi:10.1046/j.1365-2443.1998.00201.x. PMID 9753425. S2CID 6391234.
• Washington University Genome Sequencing Cente (November 1998). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
• Angrist M, Bolk S, Bentley K, et al. (1999). "Genomic structure of the gene for the SH2 and pleckstrin homology domain-containing protein GRB10 and evaluation of its role in Hirschsprung disease". Oncogene. 17 (23): 3065–70. doi:10.1038/sj.onc.1202226. PMID 9881709.
• Wang J, Dai H, Yousaf N, et al. (1999). "Grb10, a positive, stimulatory signaling adapter in platelet-derived growth factor BB-, insulin-like growth factor I-, and insulin-mediated mitogenesis". Mol. Cell. Biol. 19 (9): 6217–28. doi:10.1128/MCB.19.9.6217. PMC 84567. PMID 10454568.

پیوند به بیرون

• GRB10 Protein در سرعنوان‌های موضوعی پزشکی (MeSH) در کتابخانهٔ ملی پزشکی ایالات متحدهٔ آمریکا