رادیکسین

RDX
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1GC6, 1GC7, 1J19, 2D10, 2D11, 2D2Q, 2EMS, 2EMT, 2YVC, 2ZPY
معین‌کننده‌ها
نام‌های دیگر	RDX, DFNB24, radixin
شناسه‌های بیرونی	OMIM: 179410 MGI: 97887 HomoloGene: 37707 GeneCards: RDX
موقعیت ژن (موش) کروموزوم کروموزوم ۹ (موش)[۱] نوار 9|9 A5.3 شروع 51,958,473 bp[۱] پایان 52,011,763 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • protein homodimerization activity • protein domain specific binding • ATPase binding • protein kinase A binding • cytoskeletal protein binding • GO:0001948، GO:0016582 پیوند پروتئینی • actin binding • RNA binding • cadherin binding ترکیبات سلولی • سیتوپلاسم • membrane • focal adhesion • filopodium • ruffle • myelin sheath • پوسته یاخته • apical part of cell • stereocilium • ریزپرز • apical plasma membrane • cortical actin cytoskeleton • cleavage furrow • extracellular exosome • اسکلت سلولی • cell periphery • پای‌لایه • midbody • لولچه عرضی • cell tip • extracellular space • cell projection فرایند زیستی • regulation of cell size • establishment of endothelial barrier • microvillus assembly • regulation of organelle assembly • establishment of protein localization • positive regulation of cell migration • GO:0043087، GO:0032313، GO:0032319، GO:0032314، GO:0043088 regulation of GTPase activity • positive regulation of G1/S transition of mitotic cell cycle • negative regulation of homotypic cell-cell adhesion • regulation of actin filament bundle assembly • GO:1901313 positive regulation of gene expression • GO:0034259 negative regulation of GTPase activity • negative regulation of adherens junction organization • apical protein localization • actin filament capping • cellular response to thyroid hormone stimulus • regulation of cell shape • protein kinase A signaling • regulation of ruffle assembly • positive regulation of protein localization to early endosome • positive regulation of early endosome to late endosome transport • negative regulation of cell size • regulation of Rap protein signal transduction • cellular response to platelet-derived growth factor stimulus • barbed-end actin filament capping • protein localization to plasma membrane منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	5962	19684
آنسامبل	ENSG00000137710	ENSMUSG00000032050
یونی‌پروت	P35241	P26043
RefSeq (mRNA)	NM_001260492، NM_001260493، NM_001260494، NM_001260495، NM_001260496، XM_047427390، XM_047427391 NM_002906، NM_001260492، NM_001260493، NM_001260494، NM_001260495، NM_001260496، XM_047427390، XM_047427391	NM_001104617، NM_009041 NM_001104616، NM_001104617، NM_009041
RefSeq (پروتئین)	NP_001247422، NP_001247423، NP_001247424، NP_001247425، NP_002897 NP_001247421، NP_001247422، NP_001247423، NP_001247424، NP_001247425، NP_002897	NP_001098087، NP_033067 NP_001098086، NP_001098087، NP_033067
موقعیت (UCSC)	ن/م	Chr : 51.96 – 52.01 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

رادیکسین (انگلیسی: Radixin) یک پروتئین است که در انسان توسط ژن «RDX» بر روی بازوی بلند کروموزوم ۱۱ کُدگذاری می‌شود. رادیکسین یک پروتئین اسکلت سلولی است که در اتصال اکتین به غشای سلولی نقش دارد.^[۴][۵][۶]

رادیکسین با GNA13 تعامل پروتئین-پروتئین دارد.^[۷]

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000032050 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. Wilgenbus KK, Milatovich A, Francke U, Furthmayr H (June 1993). "Molecular cloning, cDNA sequence, and chromosomal assignment of the human radixin gene and two dispersed pseudogenes". Genomics. 16 (1): 199–206. doi:10.1006/geno.1993.1159. PMID 8486357.
5. Khan SY, Ahmed ZM, Shabbir MI, Kitajiri S, Kalsoom S, Tasneem S, Shayiq S, Ramesh A, Srisailpathy S, Khan SN, Smith RJ, Riazuddin S, Friedman TB, Riazuddin S (April 2007). "Mutations of the RDX gene cause nonsyndromic hearing loss at the DFNB24 locus". Hum Mutat. 28 (5): 417–23. doi:10.1002/humu.20469. PMID 17226784. S2CID 7671031.
6. "Entrez Gene: RDX radixin".
7. Vaiskunaite R, Adarichev V, Furthmayr H, Kozasa T, Gudkov A, Voyno-Yasenetskaya TA (August 2000). "Conformational activation of radixin by G13 protein alpha subunit". J. Biol. Chem. 275 (34): 26206–12. doi:10.1074/jbc.M001863200. PMID 10816569.

• مشارکت‌کنندگان ویکی‌پدیا. «Radixin». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۲۳ اکتبر ۲۰۲۱.

برای مطالعهٔ بیشتر

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