گیرنده بتای رتینوئیک اسید

RARB
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 1HRA, 1XAP, 4DM6, 4DM8, 4JYG, 4JYH, 4JYI
معین‌کننده‌ها
نام‌های دیگر	RARB, HAP, MCOPS12, NR1B2, RRB2, RARbeta1, retinoic acid receptor beta, RARbeta
شناسه‌های بیرونی	OMIM: 180220 MGI: 97857 HomoloGene: 68100 GeneCards: RARB
موقعیت ژن (موش) کروموزوم کروموزوم ۱۴ (موش)[۱] نوار 14 A1|14 7.08 cM شروع 5,650,540 bp[۱] پایان 6,038,924 bp[۱]
الگوی گسترش RNA More reference expression data
هستی‌شناسی ژن عملکرد ملکولی • DNA binding • sequence-specific DNA binding • RNA polymerase II transcription regulatory region sequence-specific DNA binding • GO:0001131، GO:0001151، GO:0001130، GO:0001204 DNA-binding transcription factor activity • zinc ion binding • metal ion binding • steroid hormone receptor activity • GO:0001948، GO:0016582 پیوند پروتئینی • GO:0001200، GO:0001133، GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • GO:0032403 protein-containing complex binding • retinoid X receptor binding • GO:0000975 transcription cis-regulatory region binding • transcription factor binding • nuclear receptor coactivator activity • signaling receptor activity • GO:0038050، GO:0004886، GO:0038051 nuclear receptor activity ترکیبات سلولی • سیتوپلاسم • نوکلئوپلاسم • هسته یاخته • RNA polymerase II transcription regulator complex فرایند زیستی • growth plate cartilage development • GO:0003257، GO:0010735، GO:1901228، GO:1900622، GO:1904488 positive regulation of transcription by RNA polymerase II • عصب‌زایی • ureteric bud development • GO:0009373 regulation of transcription, DNA-templated • negative regulation of cartilage development • multicellular organism growth • embryonic eye morphogenesis • positive regulation of programmed cell death • negative regulation of apoptotic process • GO:1901227 negative regulation of transcription by RNA polymerase II • retinal pigment epithelium development • transcription, DNA-templated • outflow tract septum morphogenesis • negative regulation of chondrocyte differentiation • retinoic acid receptor signaling pathway • regulation of myelination • retina development in camera-type eye • positive regulation of neuron differentiation • positive regulation of cell population proliferation • positive regulation of apoptotic process • ventricular cardiac muscle cell differentiation • transcription initiation from RNA polymerase II promoter • bone development • embryonic digestive tract development • striatum development • GO:0072468 ورارسانی پیام • negative regulation of cell population proliferation • glandular epithelial cell development • steroid hormone mediated signaling pathway • embryonic hindlimb morphogenesis • liver development • multicellular organism development • hormone-mediated signaling pathway • دگرگونی یاخته‌ • response to retinoic acid • response to lipid • gland development • bone morphogenesis • epithelium development • cellular response to retinoic acid منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی
گونه‌ها	انسان	موش
Entrez	5915	218772
آنسامبل	ENSG00000077092	ENSMUSG00000017491
یونی‌پروت	P10826 Q5QHG3	P22605
RefSeq (mRNA)	NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892 NR_110893، NM_000965، NM_001290216، NM_001290217، NM_001290266، NM_001290276، NM_001290277، NM_001290300، NM_016152، NR_110892	NM_001289761، NM_001289762، NM_011243 NM_001289760، NM_001289761، NM_001289762، NM_011243
RefSeq (پروتئین)	NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236 NP_000956، NP_001277145، NP_001277146، NP_001277195، NP_001277205، NP_001277206، NP_001277229، NP_057236 NP_001277205.1، NP_057236.1 NP_001277146.1، NP_001277205.1، NP_057236.1	NP_001276690، NP_001276691، NP_035373 NP_001276689، NP_001276690، NP_001276691، NP_035373
موقعیت (UCSC)	ن/م	Chr : 5.65 – 6.04 Mb
جستجوی PubMed	[۲]	[۳]
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

گیرنده بتای رتینوئیک اسید (انگلیسی: Retinoic acid receptor beta) یا به اختصار RAR-beta، یک پروتئین است که در انسان توسط ژن «RARB» کُدگذاری می‌شود.^[۴][۵]

این پروتئین، یک گیرنده هسته‌ای، و یکی از انواع گیرنده‌های رتینوئیک اسید است و نخستین بار، در سرطان کبد (از نوعِ هپاتوسلولار) کشف شد.

اختلال در این ژن همچنین، در ضایعات پیش‌سرطانی سرطان دهانه رحم^[۶] و نیز در سرطان مهبل ناشی از لیکن اسکلروز مهبل^[۷] مشاهده شده‌است.

منابع

1. GRCm38: Ensembl release 89: ENSMUSG00000017491 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: RARB retinoic acid receptor, beta".
5. Mattei MG, de Thé H, Mattei JF, Marchio A, Tiollais P, Dejean A (Oct 1988). "Assignment of the human hap retinoic acid receptor RAR beta gene to the p24 band of chromosome 3". Human Genetics. 80 (2): 189–90. doi:10.1007/BF00702867. PMID 2844650.
6. Rotondo JC, Bosi S, Bassi C, Ferracin M, Lanza G, Gafà R, Magri E, Selvatici R, Torresani S, Marci R, Garutti P, Negrini M, Tognon M, Martini F (April 2015). "Gene expression changes in progression of cervical neoplasia revealed by microarray analysis of cervical neoplastic keratinocytes". J Cell Physiol. 230 (4): 802–812. doi:10.1002/jcp.24808. PMID 25205602.
7. Rotondo JC, Borghi A, Selvatici R, Mazzoni E, Bononi I, Corazza M, Kussini J, Montinari E, Gafà R, Tognon M, Martini F (2018). "Association of Retinoic Acid Receptor β Gene With Onset and Progression of Lichen Sclerosus-Associated Vulvar Squamous Cell Carcinoma". JAMA Dermatology. 154 (7): 819–823. doi:10.1001/jamadermatol.2018.1373. PMC 6128494. PMID 29898214.

• مشارکت‌کنندگان ویکی‌پدیا. «Retinoic acid receptor beta». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۳ فوریه ۲۰۲۰.

برای مطالعهٔ بیشتر

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