Profiline 1

PFN1
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	1AWI, 1CF0, 1CJF, 1FIK, 1FIL, 1PFL, 2PAV, 2PBD, 3CHW, 4X1L, 4X1M, 4X25
Identifiants
Aliases	PFN1
IDs externes	OMIM: 176610 MGI: 97549 HomoloGene: 3684 GeneCards: PFN1
Position du gène (Homme)
Chr.	Chromosome 17 humain
Fin	4,949,061 bp
Position du gène (Souris)
Chr.	Chromosome 11 (souris)
Fin	70,545,470 bp
Expression génétique
	Fortement exprimé dans
	granulocyte; ; mucosa of transverse colon; ; muscle layer of sigmoid colon; ; mucosa of ileum; ; monocyte; ; aorte thoracique; ; aorte ascendante; ; stromal cell of endometrium; ; Descending thoracic aorta; ; artère coronaire gauche;
	Fortement exprimé dans
	granulocyte; ; Vésicule vitelline; ; tail of embryo; ; thymus; ; tibiofemoral joint; ; ganglion lymphatique; ; ganglion mésentérique; ; tubercule génital; ; Épiblaste; ; aorte ascendante;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	actin monomer binding; liaison protéique; adenyl-nucleotide exchange factor activity; actin binding; proline-rich region binding; liaison ARN; cadherin binding; signaling receptor binding; phosphatidylinositol-4,5-bisphosphate binding;
Composant cellulaire	cytosol; blood microparticle; membrane; focal adhesion; cortex cellulaire; exosome; cytosquelette; cytoplasme; noyau; milieu extracellulaire; neuron projection; synapse; glutamatergic synapse;
Processus biologique	positive regulation of actin filament polymerization; positive regulation of ATP-dependent activity; negative regulation of actin filament polymerization; positive regulation of ruffle assembly; regulation of transcription by RNA polymerase II; protein stabilization; positive regulation of epithelial cell migration; negative regulation of actin filament bundle assembly; neural tube closure; positive regulation of actin filament bundle assembly; negative regulation of stress fiber assembly; actin cytoskeleton organization; Wnt signaling pathway, planar cell polarity pathway; response to organic substance; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; positive regulation of DNA metabolic process; positive regulation of stress fiber assembly; cellular response to growth factor stimulus; regulation of actin filament polymerization; synapse maturation; modification of postsynaptic actin cytoskeleton;
	Sources:Amigo / QuickGO
Orthologues
	5216
	18643
	ENSG00000108518
	ENSMUSG00000018293
	P07737
	P62962
	NM_005022; NM_001375991
	NM_011072
	NP_005013; NP_001362920
	NP_035202
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

La profiline 1 est une protéine de la famille des profilines, se fixant sur l'actine. Son gène est le PFN1 situé sur le chromosome 17 humain.

Rôle

Elle intervient dans la migration des cellules souches mésenchymale et leur prolifération^[5].

En médecine

Elle est exprimée au niveau des plaques d'athérome et participe peut-être à sa genèse^[6], par prolifération des cellules endothéliales. Son expression est stimulée par l'angiotensine 2^[7].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000108518 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000018293 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Yun SP, Ryu JM, Jang MW, Han HJ, Interaction of profilin-1 and F-actin via a beta-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation, J Cell Physiol, 2011;226:559–571
↑ Caglayan E, Romeo GR, Kappert K et al. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells, PloS One, 2010;5:e13608
↑ Cheng JF, Ni GH, Chen MF et al. Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation, Vasc Pharmacol, 2011;55:34–41

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000108518 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000018293 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Yun_2011-5] Yun SP, Ryu JM, Jang MW, Han HJ, Interaction of profilin-1 and F-actin via a beta-arrestin-1/JNK signaling pathway involved in prostaglandin E(2)-induced human mesenchymal stem cells migration and proliferation, J Cell Physiol, 2011;226:559–571

[Caglayan_2010-6] Caglayan E, Romeo GR, Kappert K et al. Profilin-1 is expressed in human atherosclerotic plaques and induces atherogenic effects on vascular smooth muscle cells, PloS One, 2010;5:e13608

[Cheng_2011-7] Cheng JF, Ni GH, Chen MF et al. Involvement of profilin-1 in angiotensin II-induced vascular smooth muscle cell proliferation, Vasc Pharmacol, 2011;55:34–41

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