Caixa SOS

A caixa SOS é a rexión do promotor de varios xenes cuxo represor común é LexA, que se une a eles para reprimir a transcrición das proteínas inducidas por SOS. Isto ocorre en ausencia de danos no ADN. En presenza de danos no ADN a unión de LexA é inactivada polo activador RecA. As caixas SOS son distintas dun organismo a outro nas súas secuencias de ADN e na afinidade da unión a LexA.^[1] Ademais, as caixas SOS poden estar presentes de maneira dual e solapada, é dicir, pode haber máis dunha caixa SOS dentro do mesmo promotor.^[2]

Exemplos


Clado filoxenético	Secuencia	Referencia
Alfaproteobacterias	GAAC(N)₇GAAC GTTC(N)₇GTTC	^[3]^[4]
Betaproteobacterias Gammaproteobacterias	CTGT(N)₈ACAG	^[5]
Deltaproteobacterias	CTRHAMRYBYGTTCAGS	^[6]
Bacterias grampositivas	CGAACRNRYGTTYC	^[7]^[8]
Cianobacterias	RGTAC(N)₃DGTWCB	^[9]

Ver nomenclatura dos ácidos nucleicos para unha explicación das letras nucleotídicas que non son as típicas GATC.

Notas

↑ Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis.". Trends in Biochemical Sciences 20 (10): 416–20. PMID 8533155. doi:10.1016/s0968-0004(00)89091-x.
↑ Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology 154 (6): 1783–1792. PMC 2729051. PMID 18524933. doi:10.1099/mic.0.2007/016139-0.
↑ Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. PMID 9663685. doi:10.1046/j.1365-2958.1998.00860.x.
↑ Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. PMID 10503543. doi:10.1007/s004380051066.
↑ Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics 19 (17): 2225–36. PMID 14630651. doi:10.1093/bioinformatics/btg303.
↑ Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. PMID 12864858. doi:10.1046/j.1365-2958.2003.03592.x.
↑ Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. PMC 107149. PMID 9555905.
↑ Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. PMC 135081. PMID 12029045. doi:10.1128/JB.184.12.3287-3295.2002.
↑ Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics 271 (1): 40–9. PMID 14652736. doi:10.1007/s00438-003-0952-x.

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Bibliografía

Erill I, et al. (2004). "Differences in LexA regulon structure among Proteobacteria through in vivo assisted comparative genomics". Nucleic Acids Research 32 (22): 6617–26. PMC 545464. PMID 15604457. doi:10.1093/nar/gkh996.
Shinagawa H (1996). "SOS response as an adaptive response to DNA damage in prokaryotes". EXS 77: 221–35. PMID 8856977. doi:10.1007/978-3-0348-9088-5_14.

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[1] Walker, GC (October 1995). "SOS-regulated proteins in translesion DNA synthesis and mutagenesis.". Trends in Biochemical Sciences 20 (10): 416–20. PMID 8533155. doi:10.1016/s0968-0004(00)89091-x.

[2] Gillor, Osnat; Vriezen, Jan A. C.; Riley, Margaret A. (Jun 2008). "The role of SOS boxes in enteric bacteriocin regulation". Microbiology 154 (6): 1783–1792. PMC 2729051. PMID 18524933. doi:10.1099/mic.0.2007/016139-0.

[3] Fernández de Henestrosa AR, Rivera E, Tapias A, Barbé J (June 1998). "Identification of the Rhodobacter sphaeroides SOS box". Mol. Microbiol. 28 (5): 991–1003. PMID 9663685. doi:10.1046/j.1365-2958.1998.00860.x.

[4] Tapias A, Barbé J (August 1999). "Regulation of divergent transcription from the uvrA-ssb promoters in Sinorhizobium meliloti". Mol. Gen. Genet. 262 (1): 121–30. PMID 10503543. doi:10.1007/s004380051066.

[5] Erill I, Escribano M, Campoy S, Barbé J (November 2003). "In silico analysis reveals substantial variability in the gene contents of the gamma proteobacteria LexA-regulon". Bioinformatics 19 (17): 2225–36. PMID 14630651. doi:10.1093/bioinformatics/btg303.

[6] Campoy S, Fontes M, Padmanabhan S, Cortés P, Llagostera M, Barbé J (August 2003). "LexA-independent DNA damage-mediated induction of gene expression in Myxococcus xanthus". Mol. Microbiol. 49 (3): 769–81. PMID 12864858. doi:10.1046/j.1365-2958.2003.03592.x.

[7] Winterling KW, Chafin D, Hayes JJ, et al. (15 April 1998). "The Bacillus subtilis DinR Binding Site: Redefinition of the Consensus Sequence". J. Bacteriol. 180 (8): 2201–11. PMC 107149. PMID 9555905.

[8] Davis EO, Dullaghan EM, Rand L (June 2002). "Definition of the Mycobacterial SOS Box and Use To Identify LexA-Regulated Genes in Mycobacterium tuberculosis". J. Bacteriol. 184 (12): 3287–95. PMC 135081. PMID 12029045. doi:10.1128/JB.184.12.3287-3295.2002.

[9] Mazón G, Lucena JM, Campoy S, Fernández de Henestrosa AR, Candau P, Barbé J (February 2004). "LexA-binding sequences in Gram-positive and cyanobacteria are closely related". Mol. Genet. Genomics 271 (1): 40–9. PMID 14652736. doi:10.1007/s00438-003-0952-x.

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