CCR5

CCR5, (bahasa Inggris: chemokine receptor 5, CCR5) adalah pencerap kemokina dengan ligan, antara lain berupa RANTES, MIP-1α dan MIP-1β. CCR5 juga merupakan nama dari gen yang mengkodekan dari reseptor CC45. CCR5 terletak pada kromosom 3 pada lengan pendek (p) pada posisi 21. CCR5 terutama ada pada sel T, makrofaga, sel dendritik dan mikroglia. CCR5 memainkan peran penting pada respon peradangan terhadap infeksi, walaupun peran CCR5 untuk fungsi imun masih tidak jelas. HIV menggunakan CCR5 atau protein lainnya, CXCR4, untuk memasuki sel targetnya.

Referensi

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Pranala luar

• Video and text from a PBS documentary about the discovery of CCR5
• IUPHAR GPCR Database - CCR5 Chemokine Receptor
• fact sheet: CCR5 receptor gene and HIV infection at CDC - (note, author is not a CDC employee, and there is no public domain notice on the page, so this cannot be assumed to be public domain)
• http://www.cdc.gov/genomics/hugenet/factsheets/FS_CCR5.htm 2% African American show CCR5 indicating extremely recent origin. Smallpox initiator suspect.
• Schering-Plough Initiates Phase III Studies with CCR5-Vicriviroc in Treatment- Experienced HIV Patients.