3-Hydroxyphenazepam

Templeeti:Drugbox 3-Hydroxyphenazepam bụ benzodiazepine nwere ikike hypnotic, sedative, anxiolytic, na anticonvulsant.[1] Ọ bụ metabolite na-arụ ọrụ nke phenazepam, yana metabolite na'arụ ọrụ nke benzodiazepine prodrug cinazepam.[1][2][3] N'ihe gbasara phenazepam, 3-hydroxyphenazepam belatara ihe onwunwe myorelaxant, mana ọ fọrọ nke nta ka ọ bụrụ ihe ha nhata n'ọtụtụ ihe ndị ọzọ.[1] Dị ka benzodiazepines ndị ọzọ, 3-hydroxyphenazepam na-akpa ndị mmadụ n'ihe ndị mere n'oge gara maka nsogbụ ndị na eme àgwà dị ka modulator allosteric dị mma nke ebe benzodiazepine nke onye na-anabata GABAA na uru EC50 nke 10.3 nM.[4][5][6] A na-ere ya n'ịntanetị dị ka ọgwụ mmepụta.[7][8][9][10]

Hụkwa

[dezie | dezie ebe o si]
  • Lorazepam, ọgwụ nwere ikike
  • Nifoxipam
  • Nitemazepam

Ntụaka

[dezie | dezie ebe o si]
  1. ↑ 1.0 1.1 1.2 (31 May 1986) Drug dependence and emotional behavior: neurophysiological and neurochemical approaches. Consultants Bureau. ISBN 978-0-306-10984-3. 
  2. ↑ (20 December 2013) Thin Layer Chromatography in Drug Analysis. CRC Press, 299–. ISBN 978-1-4665-0715-9. 
  3. ↑ (2011) "Elimination kinetics of the novel prodrug cinazepam possessing psychotropic activity in mice". Pharmacological Reports 63 (5): 1093–1100. DOI:10.1016/s1734-1140(11)70628-4. PMID 22180351. 
  4. ↑ Phenazepam Pre-Review Report. World Health Organization (WHO) (November 2015).
  5. ↑ (2000) "Modulation of GABA-activated currents by phenazepam and its metabolites in isolated rat purkinje neurons". Neurophysiology 32 (3): 192. DOI:10.1007/BF02506568. ISSN 0090-2977. 
  6. ↑ (2014) "Pharmacodynamical and Neuroreceptor Analysis of the Permeability of the Blood-Brain Barrier for Derivatives of 1,4-Benzodiazepine". Neurophysiology 46 (3): 199–205. DOI:10.1007/s11062-014-9429-2. ISSN 0090-2977. 
  7. ↑ 3-hydroxyphenazepam. New Synthetic Drugs Database. Archived from the original on 2016-09-28. Retrieved on 2016-05-30.
  8. ↑ (April 2017) "Detectability of designer benzodiazepines in CEDIA, EMIT II Plus, HEIA, and KIMS II immunochemical screening assays". Drug Testing and Analysis 9 (4): 640–645. DOI:10.1002/dta.2003. PMID 27366870. 
  9. ↑ (November 2016) "Characterization and in vitro phase I microsomal metabolism of designer benzodiazepines - an update comprising adinazolam, cloniprazepam, fonazepam, 3-hydroxyphenazepam, metizolam and nitrazolam". Journal of Mass Spectrometry 51 (11): 1080–1089. DOI:10.1002/jms.3840. PMID 27535017. 
  10. ↑ (March 2018) "Experimental versus theoretical log D7.4 , pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances". Drug Testing and Analysis 10 (8): 1258–1269. DOI:10.1002/dta.2387. PMID 29582576.