Oleamide

 

Oleamide bụ ihe na-emepụta ihe na usoro CH3 (CH2) 7CH=CH (CH2) 6CONH2.[1] Ọ bụ amide sitere na fatty acid oleic acid. Ọ bụ ihe siri ike na-enweghị ụcha ma na-eme n'okike. Mgbe ụfọdụ n'ime ụmụ ndị ogbi a na-akpọ ya amide abụba (FAPA), a na-emepụta ya site na N-oleoylglycine.[2]

Akụkụ nke kemịkal na ahụike

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N'ihe gbasara ihe okike, a chọpụtara oleamide na plasma mmadụ. E mechara gosipụta na ọ na-agbakọta na mmiri ụbụrụ n'oge ochie ọbá Akwụkwọ abụ ọma enweghị ụra ma na-akpali ụra n'ime ụmụ anụmanụ.[2][3]

A na-ewere ya dị ka ọgwụgwọ nwere ike ịgwọ nsogbu ọnọdụ uche na nke ukwu nke a na ụra, yana ịda mbà n'obi nke cannabinoid na-achịkwa.[4]

N'ihe gbasara mmetụta ya na-akpali ụra, a na-eche na oleamide na-emekọrịta ihe na ọtụtụ usoro neurotransmitter.[5][6] Ụfọdụ ọmụmụ in-vitro na-egosi na cis-oleamide bụ agonist ndị mere n'oge ochie maka onye na-anabata cannabinoid CB-1 na njikọ gburugburu 8 micromolar.[7] Otú ọ dị, n'ihi obere njikọ oleamide maka CB-1 na ejighị n'aka banyere njupụta na ọrụ nke oleamide na-adị ndụ, a na-ekwu na ọ bụ oge ịhazi oleamide dị ka endocannabinoid.[8] Na doses buru ibu oleamide nwere ike belata okpomọkụ ahụ nke òké site na ihe dị ka 2 degrees, na mmetụta na-adịru ihe dị ka awa abụọ.[6] A maghị usoro nke a.[6]

Oleamide na-agbari ngwa ngwa site na fatty acid amide hydrolase ndị mmadụ n'ihe ndị mere (FAAH), otu enzyme nke na-agbanye anandamide.[6][9] A na-ekwu na mmetụta ụfọdụ nke oleamide na-esite na mmụba nke anandamide site na mgbochi nke FAAH.[6]

Ihe ndị ọzọ

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Oleamide emepụtara emepụta ihe nwere ọtụtụ ọrụ mmepụta ihe gụnyere dị kà àkà gbúrù nwéré ihe na-agba ọsọ, mmanụ, na ihe na-egbochi corrosion.

A chọpụtara na oleamide na-agbapụta plastik polypropylene na nnwale ụlọ nyocha, na-emetụta nsonaazụ nnwale.[10] Ebe ọ bụ na a na-eji polypropylene eme ihe n'ọtụtụ ihe na ụdị nke oriri dịka ndị maka yogọt, a na-amụ nsogbu ahụ.[11]

Oleamide bụ "otu n'ime ihe ndị na-abụghị cannabisinoid na-ejikọta ya na ngwaahịa Spice".[12] Nnyocha nke ngwaahịa ọrụ nkụzi afọ ojuju site 44 synthetic cannabinoid kpughere oleamide na 7 n'ime ngwaahịa ndị a nwalere.[13]

Hụkwa

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  • Anandamide
  • Fatty acid amide hydrolase
  • Virodhamine

Ntụaka

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  1. ↑ Oleamide.
  2. ↑ 2.0 2.1 McKinney (June 2005). "Structure and Function of Fatty Acid Amide Hydrolase". Annual Review of Biochemistry 74 (1): 411–432. DOI:10.1146/annurev.biochem.74.082803.133450. PMID 15952893. 
  3. ↑ Cravatt (9 June 1995). "Chemical characterization of a family of brain lipids that induce sleep". Science 268 (5216): 1506–1509. DOI:10.1126/science.7770779. PMID 7770779. 
  4. ↑ Mechoulam (September 1997). "Anandamide may mediate sleep induction". Nature 389 (6646): 25–26. DOI:10.1038/37891. PMID 9288961. 
  5. ↑ Fedorova (October 2001). "Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems". The Journal of Pharmacology and Experimental Therapeutics 299 (1): 332–42. PMID 11561096. 
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Hiley (13 April 2007). "Oleamide: A Fatty Acid Amide Signaling Molecule in the Cardiovascular System?: OLEAMIDE". Cardiovascular Drug Reviews 25 (1): 46–60. DOI:10.1111/j.1527-3466.2007.00004.x. 
  7. ↑ Leggett (January 2004). "Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors.". British Journal of Pharmacology 141 (2): 253–62. DOI:10.1038/sj.bjp.0705607. PMID 14707029. 
  8. ↑ Fowler (January 2004). "Oleamide: a member of the endocannabinoid family?: Commentary". British Journal of Pharmacology 141 (2): 195–196. DOI:10.1038/sj.bjp.0705608. PMID 14691053. 
  9. ↑ Maurelli (11 December 1995). "Two novel classes of neuroactive fatty acid amides are substrates for mouse neuroblastoma 'anandamide amidohydrolase'". FEBS Letters 377 (1): 82–86. DOI:10.1016/0014-5793(95)01311-3. PMID 8543025. 
  10. ↑ McDonald (7 November 2008). "Bioactive Contaminants Leach from Disposable Laboratory Plasticware". Science 322 (5903): 917. DOI:10.1126/science.1162395. PMID 18988846. 
  11. ↑ Mittelstaedt. "Researchers Raise Alarm After Chemical Leak Found In Common Plastic", Globe and Mail, 6 November 2008. Retrieved on 10 June 2013.
  12. ↑ Fattore (21 September 2011). "Beyond THC: The New Generation of Cannabinoid Designer Drugs". Frontiers in Behavioral Neuroscience 5: 60. DOI:10.3389/fnbeh.2011.00060. PMID 22007163. 
  13. ↑ Uchiyama (May 2010). "Chemical analysis of synthetic cannabinoids as designer drugs in herbal products". Forensic Science International 198 (1–3): 31–38. DOI:10.1016/j.forsciint.2010.01.004. PMID 20117892.