肝細胞増殖因子

HGF
PDBに登録されている構造 PDB オルソログ検索: RCSB PDBe PDBj PDBのIDコード一覧 1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J, 4O3T, 4O3U, 5COE, 5CP9, 5CS1, 5CS3, 5CS5, 5CS9, 5CSQ, 5CT1, 5CT2, 5CT3, 4D3C
識別子
記号	HGF, DFNB39, F-TCF, HGFB, HPTA, SF, hepatocyte growth factor
外部ID	OMIM: 142409 MGI: 96079 HomoloGene: 503 GeneCards: HGF
遺伝子の位置 (ヒト) 染色体 7番染色体 (ヒト)[1] バンド データ無し 開始点 81,699,010 bp[1] 終点 81,770,438 bp[1]
遺伝子の位置 (マウス) 染色体 5番染色体 (マウス)[2] バンド データ無し 開始点 16,758,493 bp[2] 終点 16,825,150 bp[2]
RNA発現パターン さらなる参照発現データ
遺伝子オントロジー 分子機能 • 血漿タンパク結合 • identical protein binding • chemoattractant activity • protein heterodimerization activity • growth factor activity • serine-type endopeptidase activity • protein tyrosine kinase activity • phosphatidylinositol-4,5-bisphosphate 3-kinase activity 細胞の構成要素 • 膜 • 細胞外領域 • platelet alpha granule lumen • 細胞外空間 生物学的プロセス • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process • negative regulation of hydrogen peroxide-mediated programmed cell death • positive regulation of neuron projection regeneration • positive regulation of interleukin-10 production • positive regulation of cell migration • cellular response to hepatocyte growth factor stimulus • negative regulation of release of cytochrome c from mitochondria • negative regulation of interleukin-6 production • platelet degranulation • negative regulation of apoptotic process • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling • positive regulation of angiogenesis • positive regulation of myelination • positive regulation of osteoblast differentiation • myoblast proliferation • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • animal organ regeneration • cell morphogenesis • positive regulation of cell population proliferation • hyaluronan metabolic process • positive regulation of DNA biosynthetic process • negative regulation of peptidyl-serine phosphorylation • 上皮間葉転換 • positive regulation of peptidyl-tyrosine phosphorylation • cell chemotaxis • 肝臓発生 • positive regulation of phosphatidylinositol 3-kinase signaling • regulation of p38MAPK cascade • 細胞増殖 • negative regulation of autophagy • hepatocyte growth factor receptor signaling pathway • negative regulation of inflammatory response • positive regulation of transcription by RNA polymerase II • regulation of tau-protein kinase activity • タンパク質分解 • positive chemotaxis • MAPK cascade • peptidyl-tyrosine phosphorylation • phosphatidylinositol phosphate biosynthetic process • 体細胞分裂 • regulation of signaling receptor activity • positive regulation of protein kinase B signaling • positive regulation of protein phosphorylation • サイトカイン媒介シグナル伝達経路 • epithelial cell proliferation 出典:Amigo / QuickGO
オルソログ
種	ヒト	マウス
Entrez	3082	15234
Ensembl	ENSG00000019991	ENSMUSG00000028864
UniProt	P14210,C9JS80	Q08048
RefSeq (mRNA)	NM_000601 NM_001010931 NM_001010932 NM_001010933 NM_001010934	NM_010427 NM_001289458 NM_001289459 NM_001289460 NM_001289461
RefSeq (タンパク質)	NP_000592 NP_001010931 NP_001010932 NP_001010933 NP_001010934	NP_001276387 NP_001276388 NP_001276389 NP_001276390 NP_034557
場所 (UCSC)	Chr 7: 81.7 – 81.77 Mb	Chr 7: 16.76 – 16.83 Mb
PubMed検索	[3]	[4]
ウィキデータ
閲覧/編集 ヒト 閲覧/編集 マウス

肝細胞増殖因子（かんさいぼうぞうしょくいんし、HGF英: Hepatocyte growth factorまたはSF英: scatter factor）は、分子量が約9万の一本鎖のタンパク質。

HGF activator (HGFA)と呼ばれるセリンプロテアーゼにより分子量約６万のα鎖と約３万のβ鎖に切断されると生理活性を発現する。

1. ^ GRCh38: Ensembl release 89: ENSG00000019991 - Ensembl, May 2017
2. ^ GRCm38: Ensembl release 89: ENSMUSG00000028864 - Ensembl, May 2017
3. Human PubMed Reference:
4. Mouse PubMed Reference: