KLF4

KLF4
사용 가능한 구조 PDB 동원체 검색: PDBe RCSB PDB ID 코드 목록 2WBS, 2WBU, 4M9E
식별자
다른 이름	KLF4, EZF, GKLF, Kruppel-like factor 4 (gut), Kruppel like factor 4
외부 ID	OMIM: 602253 MGI: 1342287 HomoloGene: 3123 GeneCards: KLF4
유전자 위치 (인간) 염색체 9번 염색체[1] 자리 9q31.2 시작 107,484,852 bp[1] 끝 107,490,482 bp[1]
유전자 위치 (쥐) 염색체 4번 염색체 (쥐)[2] 자리 4 B3|4 29.76 cM 시작 55,527,143 bp[2] 끝 55,532,466 bp[2]
RNA 발현 패턴 Bgee 인간 쥐(동원체) 최상위 발현 skin of thigh skin of hip 음경 mucosa of sigmoid colon synovial joint skin of arm 배의 피부 음문 jejunal mucosa mucosa of pharynx 최상위 발현 epithelium of stomach mucous cell of stomach skin of external ear conjunctival fornix left colon pyloric antrum 융털 탯줄 자궁경부 stria vascularis 추가 참조 발현 데이터 BioGPS 추가 참조 발현 데이터
유전자 온톨로지 분자 함수 DNA 결합 sequence-specific DNA binding beta-catenin binding phosphatidylinositol 3-kinase regulator activity DNA-binding transcription factor activity zinc ion binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor binding cis-regulatory region sequence-specific DNA binding 금속 이온 결합 RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity 단백질 결합 nucleic acid binding double-stranded DNA binding promoter-specific chromatin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription coregulator binding histone deacetylase binding 세포 성분 세포질 transcription regulator complex 핵질 염색질 세포핵 생물학적 과정 negative regulation of chemokine (C-X-C motif) ligand 2 production epidermal cell differentiation cellular response to retinoic acid negative regulation of protein kinase B signaling negative regulation of muscle hyperplasia negative regulation of smooth muscle cell proliferation positive regulation of protein metabolic process negative regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of axon regeneration cellular response to peptide DNA를 주형으로 한 전사의 조절 positive regulation of hemoglobin biosynthetic process response to retinoic acid somatic stem cell population maintenance cellular response to laminar fluid shear stress regulation of transcription by RNA polymerase II 세포 분화 epidermis morphogenesis positive regulation of nitric oxide biosynthetic process cellular response to growth factor stimulus cellular response to organic cyclic compound post-embryonic hemopoiesis negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II response to organic substance negative regulation of gene expression negative regulation of response to cytokine stimulus DNA를 주형으로 한 전사 negative regulation of DNA-binding transcription factor activity negative regulation of phosphatidylinositol 3-kinase signaling stem cell population maintenance negative regulation of cell migration involved in sprouting angiogenesis positive regulation of gene expression negative regulation of cell migration regulation of cell population proliferation post-embryonic camera-type eye development regulation of phosphatidylinositol 3-kinase activity positive regulation of telomerase activity canonical Wnt signaling pathway negative regulation of ERK1 and ERK2 cascade regulation of cell differentiation mesodermal cell fate determination negative regulation of heterotypic cell-cell adhesion negative regulation of transcription, DNA-templated negative regulation of NF-kappaB transcription factor activity cellular response to cycloheximide negative regulation of inflammatory response fat cell differentiation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation cellular response to hydrogen peroxide negative regulation of leukocyte adhesion to arterial endothelial cell positive regulation of core promoter binding cellular response to leukemia inhibitory factor negative regulation of angiogenesis pri-miRNA transcription by RNA polymerase II negative regulation of G1/S transition of mitotic cell cycle positive regulation of transcription, DNA-templated positive regulation of sprouting angiogenesis 출처: Amigo / QuickGO
동원체 종 인간 쥐 앙트레 9314 16600 앙상블 ENSG00000136826 ENSMUSG00000003032 유니프롯 O43474 Q60793 RefSeq (mRNA) NM_001314052 NM_004235 NM_010637 RefSeq(단백질) NP_001300981 NP_004226 NP_034767 위치(UCSC) Chr 9: 107.48 – 107.49 Mb Chr 4: 55.53 – 55.53 Mb PubMed 검색 [3] [4]
위키데이터
인간 보기/편집 쥐 보기/편집

KLF4(Krüppel-like factor 4)는 상대적으로 큰 SP1 유사 전사인자 계열에 속하는 징크 핑거 전사 인자 KLF 계열의 일부이다. KLF4는 증식, 분화, 세포사멸 및 체세포 재프로그래밍의 조절에 관여한다. 또한 KLF4가 대장암을 포함한 특정 암에서 종양 억제인자라는 증거도 있다. 카르복실 말단에는 또 다른 KLF인 KLF2와 밀접하게 관련된 3개의 C2H2-아연 핑거가 있다. 여기에는 핵에 위치하도록 신호를 보내는 두 개의 핵 위치 확인 시퀀스가 ​​있다. 배아줄기세포(ESC)에서 KLF4는 줄기 유사 능력을 나타내는 좋은 지표인 것으로 입증되었다. 중간엽 줄기세포(MSC)에서도 마찬가지라고 한다.

인간의 경우, 단백질은 513개의 아미노산으로 이루어져 있으며 예상 분자량은 약 55kDa이고 KLF4 유전자에 의해 암호화된다. KLF4 유전자는 침팬지, 히말라야원숭이, 개, 소, 생쥐, 쥐, 닭, 제브라피쉬 및 개구리에서 보존된다. KLF4는 1996년에 처음 확인되었다.

외부 링크

• 의학주제표목 (MeSH)의 KLF4+protein,+human
• KLF4 microarray expression results and literature

1. GRCh38: Ensembl release 89: ENSG00000136826 - 앙상블, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000003032 - 앙상블, May 2017
3. “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
4. “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》.