사이토글로빈

CYGB
사용 가능한 구조
PDB동원체 검색: PDBe RCSB
식별자
다른 이름CYGB, HGB, STAP, cytoglobin
외부 IDOMIM: 608759 MGI: 2149481 HomoloGene: 12706 GeneCards: CYGB
RNA 발현 패턴
Bgee
인간쥐(동원체)
최상위 발현
  • cardiac muscle tissue of right atrium

  • myocardium of left ventricle

  • right auricle

  • apex of heart

  • subcutaneous adipose tissue

  • right lobe of thyroid gland

  • left lobe of thyroid gland

  • gastric mucosa

  • 자궁목관

  • mucosa of ileum
최상위 발현
  • 심실중격

  • 대동맥 판막

  • 상행대동맥

  • habenula

  • dorsal tegmental nucleus

  • 발목

  • lateral hypothalamus

  • central gray substance of midbrain

  • neural layer of retina

  • medial vestibular nucleus
추가 참조 발현 데이터
BioGPS
추가 참조 발현 데이터
위키데이터
인간 보기/편집쥐 보기/편집

사이토글로빈(영어: cytoglobin)은 사람과 포유류의 유전자인 CYGB의 단백질 산물이다.[5]

사이토글로빈은 모든 조직에서 발현되며, 특히 해양 포유류에서 가장 많이 활용되는 글로빈 분자이다. 사이토글로빈은 2001년에 발견되었으며,[6] 2002년에 사이토글로빈으로 명명되었다.[7] 사이토글로빈은 저산소증으로부터 보호하는 역할을 하는 것으로 생각된다. 사이토글로빈의 예상되는 기능은 동맥혈에서 뇌로 산소를 전달하는 것이다.[8]

기능

[편집]

사이토글로빈은 조직을 통한 산소의 확산을 촉진하고 산화 질소 또는 활성 산소를 제거하거나 산화 스트레스 동안 보호 기능을 제공할 수 있는 어디에서나 발현되는 6배위 헤모글로빈이다.[5][9]

활용

[편집]

CYGB 발현은 손상된 사람의 간의 간 성상세포와 간문맥 근섬유아세포를 구별할 수 있는 특정 마커로 사용될 수 있다.[10]

같이 보기

[편집]

각주

[편집]
  1. ↑ 가 나 다 GRCh38: Ensembl release 89: ENSG00000161544 - 앙상블, May 2017
  2. ↑ 가 나 다 GRCm38: Ensembl release 89: ENSMUSG00000020810 - 앙상블, May 2017
  3. ↑ “Human PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  4. ↑ “Mouse PubMed Reference:”. 《National Center for Biotechnology Information, U.S. National Library of Medicine》. 
  5. ↑ 가 나 “Entrez Gene: CYGB cytoglobin”. 
  6. ↑ Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). “Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells”. 《The Journal of Biological Chemistry》 276 (27): 25318–23. doi:10.1074/jbc.M102630200. PMID 11320098. 
  7. ↑ Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). “Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues”. 《Molecular Biology and Evolution》 19 (4): 416–21. doi:10.1093/oxfordjournals.molbev.a004096. PMID 11919282. 
  8. ↑ “Why Diving Marine Mammals Resist Brain Damage from Low Oxygen”. 《ScienceDaily》. 2007년 12월 20일. 
  9. ↑ Trent JT, Hargrove MS (May 2002). “A ubiquitously expressed human hexacoordinate hemoglobin”. 《The Journal of Biological Chemistry》 277 (22): 19538–45. doi:10.1074/jbc.M201934200. PMID 11893755. 
  10. ↑ Motoyama H, Komiya T, Thuy le TT, Tamori A, Enomoto M, Morikawa H, Iwai S, Uchida-Kobayashi S, Fujii H, Hagihara A, Kawamura E, Murakami Y, Yoshizato K, Kawada N (Feb 2014). “Cytoglobin is expressed in hepatic stellate cells, but not in myofibroblasts, in normal and fibrotic human liver”. 《Laboratory Investigation》 94 (2): 192–207. doi:10.1038/labinvest.2013.135. PMID 24296877. 

더 읽을거리

[편집]
  • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K (Jul 2001). “Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells”. 《The Journal of Biological Chemistry》 276 (27): 25318–23. doi:10.1074/jbc.M102630200. PMID 11320098. 
  • Burmester T, Ebner B, Weich B, Hankeln T (Apr 2002). “Cytoglobin: a novel globin type ubiquitously expressed in vertebrate tissues”. 《Molecular Biology and Evolution》 19 (4): 416–21. doi:10.1093/oxfordjournals.molbev.a004096. PMID 11919282. 
  • Asahina K, Kawada N, Kristensen DB, Nakatani K, Seki S, Shiokawa M, Tateno C, Obara M, Yoshizato K (Sep 2002). “Characterization of human stellate cell activation-associated protein and its expression in human liver”. 《Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression》 1577 (3): 471–5. doi:10.1016/s0167-4781(02)00477-3. PMID 12359339. 
  • Sawai H, Kawada N, Yoshizato K, Nakajima H, Aono S, Shiro Y (May 2003). “Characterization of the heme environmental structure of cytoglobin, a fourth globin in humans”. 《Biochemistry》 42 (17): 5133–42. doi:10.1021/bi027067e. PMID 12718557. 
  • Geuens E, Brouns I, Flamez D, Dewilde S, Timmermans JP, Moens L (Aug 2003). “A globin in the nucleus!”. 《The Journal of Biological Chemistry》 278 (33): 30417–20. doi:10.1074/jbc.C300203200. PMID 12796507. 
  • Hamdane D, Kiger L, Dewilde S, Green BN, Pesce A, Uzan J, Burmester T, Hankeln T, Bolognesi M, Moens L, Marden MC (Dec 2003). “The redox state of the cell regulates the ligand binding affinity of human neuroglobin and cytoglobin”. 《The Journal of Biological Chemistry》 278 (51): 51713–21. doi:10.1074/jbc.M309396200. PMID 14530264. 
  • Schmidt M, Gerlach F, Avivi A, Laufs T, Wystub S, Simpson JC, Nevo E, Saaler-Reinhardt S, Reuss S, Hankeln T, Burmester T (Feb 2004). “Cytoglobin is a respiratory protein in connective tissue and neurons, which is up-regulated by hypoxia”. 《The Journal of Biological Chemistry》 279 (9): 8063–9. doi:10.1074/jbc.M310540200. PMID 14660570. 
  • Hünermund G, Schirmacher A, Ringelstein B, Young P, Watts GD, Meuleman J, Nelis E, Chance PF, Timmerman V, Stögbauer F, Kuhlenbäumer G (Apr 2004). “Genomic organization and mutation analysis of three candidate genes for hereditary neuralgic amyotrophy”. 《Muscle & Nerve》 29 (4): 601–4. doi:10.1002/mus.20009. PMID 15052627. S2CID 39945876. 
  • de Sanctis D, Dewilde S, Pesce A, Moens L, Ascenzi P, Hankeln T, Burmester T, Bolognesi M (Feb 2004). “Crystal structure of cytoglobin: the fourth globin type discovered in man displays heme hexa-coordination”. 《Journal of Molecular Biology》 336 (4): 917–27. doi:10.1016/j.jmb.2003.12.063. PMID 15095869. S2CID 21144924. 
  • Sugimoto H, Makino M, Sawai H, Kawada N, Yoshizato K, Shiro Y (Jun 2004). “Structural basis of human cytoglobin for ligand binding”. 《Journal of Molecular Biology》 339 (4): 873–85. doi:10.1016/j.jmb.2004.04.024. PMID 15165856. 
  • Fago A, Hundahl C, Dewilde S, Gilany K, Moens L, Weber RE (Oct 2004). “Allosteric regulation and temperature dependence of oxygen binding in human neuroglobin and cytoglobin. Molecular mechanisms and physiological significance”. 《The Journal of Biological Chemistry》 279 (43): 44417–26. doi:10.1074/jbc.M407126200. PMID 15299006. 
  • Hamdane D, Kiger L, Dewilde S, Uzan J, Burmester T, Hankeln T, Moens L, Marden MC (Apr 2005). “Hyperthermal stability of neuroglobin and cytoglobin”. 《The FEBS Journal》 272 (8): 2076–84. doi:10.1111/j.1742-4658.2005.04635.x. PMID 15819897. S2CID 13377138. 
  • Sawai H, Makino M, Mizutani Y, Ohta T, Sugimoto H, Uno T, Kawada N, Yoshizato K, Kitagawa T, Shiro Y (Oct 2005). “Structural characterization of the proximal and distal histidine environment of cytoglobin and neuroglobin”. 《Biochemistry》 44 (40): 13257–65. doi:10.1021/bi050997o. PMID 16201751. 
  • Shaw RJ, Liloglou T, Rogers SN, Brown JS, Vaughan ED, Lowe D, Field JK, Risk JM (Feb 2006). “Promoter methylation of P16, RARbeta, E-cadherin, cyclin A1 and cytoglobin in oral cancer: quantitative evaluation using pyrosequencing”. 《British Journal of Cancer》 94 (4): 561–8. doi:10.1038/sj.bjc.6602972. PMC 2361183. PMID 16449996. 
  • McRonald FE, Liloglou T, Xinarianos G, Hill L, Rowbottom L, Langan JE, Ellis A, Shaw JM, Field JK, Risk JM (Apr 2006). “Down-regulation of the cytoglobin gene, located on 17q25, in tylosis with oesophageal cancer (TOC): evidence for trans-allele repression”. 《Human Molecular Genetics》 15 (8): 1271–7. doi:10.1093/hmg/ddl042. PMID 16510494. 
  • Xinarianos G, McRonald FE, Risk JM, Bowers NL, Nikolaidis G, Field JK, Liloglou T (Jul 2006). “Frequent genetic and epigenetic abnormalities contribute to the deregulation of cytoglobin in non-small cell lung cancer”. 《Human Molecular Genetics》 15 (13): 2038–44. doi:10.1093/hmg/ddl128. PMID 16698880. 

외부 링크

[편집]