Receptorium histamini H4

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Receptorium histamini H₄
Alia	HRH4, AXOR35, BG26, GPCR105, GPRv53, H4, H4R, HH4R
Fontes ext.	OMIM: 606792
Locus geni (homo)

Chr.	Chromosoma 18 (humanum)

Receptorium histamini H₄, abbreviatura HRH4 est receptorium histamini et familiae receptoriorum proteino G copulatorum.

Stimulatio HRH4 chemotaxem mastocytorum atque muitationem formae granulocytorum eosinophilorum contrahit^[1]. In testium cellulis Leydigiensibus steroidogenesem receptoriorum H₄ ope inhibere videtur^[2].

Agonista est Clozapinum, antagonista Pimozidum.

Polymorphismi geni receptorii cancrum contrahere potest.

Historia

In anno 2000 essentia receptorii histamini H₄ descripta est^[3]^[4]. Exaequatum cum geno receptorii histamini H₃ 40% aminoacidorum illis HRH4 aequalia sunt.

Natura receptorii histamini H₄

Natura genetica

Genum receptorii histamini H₄, HRH4 nominatum, chromosomate 18 locatum est.

Structura receptorii

Receptorium ex 390 aminoacidis constitutum est.

HRH4 et cancer

Mutatio geni receptorii histamini H₄ nonnumquam formas cancri instigare videtur, ut cancrum pulmonis.

Cancer pulmonis

Conferatur pagina principalis Cancer pulmonis.

Cuique polymorphismorum geneticorum periculum deformationis carcinomatosae pulmonum inhabitet. Transitio carcinomatosa in cancros pulmonis non cellularum parvarum in parte polymorphismo geni receptorii H₄ sociatus sit^[5].

Notae

↑ Hofstra C. L., Desai P. J., Thurmond R. L., Fung-Leung W. P. (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". The journal of pharmacology and experimental therapeutics 305 (3): 1212-21
↑ Abiuso A. M., Berensztein E., Pagotto R. M.ö, Pereyra E. N., Medina V., Martinel Lamas D. J., Besio Moreno M., Pignataro O. P., Mondillo C. (2014). "H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells". The journal of endocrinology 223 (3): 241-53
↑ Oda T., Morikawa N., Saito Y., Masuho Y., Matsumoto S. (2000). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". The journal of biological chemistry 275 (47): 36781-6
↑ Nakamura T., Itadani H, Hidaka Y., Ohta M., Tanaka K. (2000). "Molecular cloning and characterization of a new human histamine receptor, HH4R". Biochemical and biophysical research communications 279 (2): 615-20
↑ Cai W. K., Zhang J. B., Chen J. H., Meng J. R., Ma X., Zhang J., Zhou Y. L., Xu G. L., He G. H. (2017). "The HRH4 rs11662595 mutation is associated with histamine H4 receptor dysfunction and with increased epithelial-to-mesenchymal transition progress in non-small cell lung cancer". Biochimica et biophysica acta. Molecular basis of disease 1863 (11): 2954-63

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Receptoria histamini


Receptorium histamini • Receptorium histamini H1 • Receptorium histamini H2 • Receptorium histamini H3 • Receptorium histamini H4

[1] Hofstra C. L., Desai P. J., Thurmond R. L., Fung-Leung W. P. (2003). "Histamine H4 receptor mediates chemotaxis and calcium mobilization of mast cells". The journal of pharmacology and experimental therapeutics 305 (3): 1212-21

[2] Abiuso A. M., Berensztein E., Pagotto R. M.ö, Pereyra E. N., Medina V., Martinel Lamas D. J., Besio Moreno M., Pignataro O. P., Mondillo C. (2014). "H4 histamine receptors inhibit steroidogenesis and proliferation in Leydig cells". The journal of endocrinology 223 (3): 241-53

[3] Oda T., Morikawa N., Saito Y., Masuho Y., Matsumoto S. (2000). "Molecular cloning and characterization of a novel type of histamine receptor preferentially expressed in leukocytes". The journal of biological chemistry 275 (47): 36781-6

[4] Nakamura T., Itadani H, Hidaka Y., Ohta M., Tanaka K. (2000). "Molecular cloning and characterization of a new human histamine receptor, HH4R". Biochemical and biophysical research communications 279 (2): 615-20

[5] Cai W. K., Zhang J. B., Chen J. H., Meng J. R., Ma X., Zhang J., Zhou Y. L., Xu G. L., He G. H. (2017). "The HRH4 rs11662595 mutation is associated with histamine H4 receptor dysfunction and with increased epithelial-to-mesenchymal transition progress in non-small cell lung cancer". Biochimica et biophysica acta. Molecular basis of disease 1863 (11): 2954-63

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