SOX10

SOX10
Identifikatorar
Andre namn	SOX10, DOM, PCWH, WS2E, WS4, WS4C, SRY-box 10, SRY-box transcription factor 10, SOX-10
Eksterne ID-ar	OMIM: 602229 MGI: 98358 HomoloGene: 5055 GeneCards: SOX10
Genplassering (menneske) Kromosom Menneskekromosom 22[1] Band 22q13.1 Byrjing 37,970,686 bp[1] Ende 37,987,422 bp[1]
Genplassering (mus) Kromosom Musekromosom 15[2] Band 15 E1|15 37.7 cM Byrjing 79,039,108 bp[2] Ende 79,049,440 bp[2]
RNA-uttrykksmønster Bgee Top expressed in complexus olivaris inferior nervus suralis dorsal motor nucleus of vagus nerve inferior ganglion of vagus nerve trigeminusganglion spinalganglion 1. cervikalsegment nucleus subthalamicus ventral tegmental area glandula parotis Meir referanseuttrykksdata BioGPS More reference expression data
Genontologi Molekylær funksjon GO:0001105 transcription coactivator activity transcription factor binding chromatin binding GO:0001948, GO:0016582 proteinbinding identical protein binding promoter-specific chromatin binding DNA-binding GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Sellekomponent cytoplasma nukleoplasma cellekjerne kromatin mitokondrium mitochondrial outer membrane membran extrinsic component of mitochondrial outer membrane Biologisk prosess GO:0009373 regulation of transcription, DNA-templated GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II morfogenese av anatomisk struktur transcription, DNA-templated stamcelledifferensiering GO:0045996 negative regulation of transcription, DNA-templated transcription elongation from RNA polymerase II promoter negative regulation of Schwann cell proliferation GO:1901313 positiv regulering av genekspresjon positive regulation of myelination cellular response to progesterone stimulus GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated oligodendrocyte development central nervous system myelination oligodendrocyte differentiation in utero embryonic development neural crest cell migration morfogenese av epitel positive regulation of neuroblast proliferation utvikling av sentralnervesystem peripheral nervous system development positive regulation of gliogenesis celledifferensiering melanocyte differentiation lacrimal gland development negativ regulering av apoptoseprosess GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II cellemodning enteric nervous system development digestive tract morphogenesis utviklingsvekst morphogenesis of a branching epithelium negative regulation of canonical Wnt signaling pathway Kjelder:Amigo / QuickGO
Ortologar
Art	Menneske	Mus
Entrez	6663	20665
Ensembl	ENSG00000100146	ENSMUSG00000033006
UniProt	P56693	Q04888
RefSeq (mRNA)	NM_006941	NM_011437
RefSeq (protein)	NP_008872	NP_035567
Plassering (UCSC)	Chr 22: 37.97 – 37.99 Mb	Chr 15: 79.04 – 79.05 Mb
PubMed-søk	[3]	[4]
Wikidata
sjå/endra menneske sjå/endra mus

SOX10 er ein transkripsjonsfaktor i SOX-genfamilien. Han er naudsynt for utvikling av både Schwann-seller og oligodendrocyttar.^[5] Han er òg naudsynt for utviklinga og vedlikehaldet av melanocyttar.^[6]

SOX10 har ulike bindingssete i oligodendrocyttar og Schwann-seller. I oligodendrocyttar vekselverkar SOX10 med protein som transkripsjonsfaktorane OLIG1, OLIG2 og myelinregulerande faktor. SOX10 bunde til OLIG1 aktiverer avskrivinga av genet til basisk myelinprotein (MBP). I Schwann-seller vekselverkar SOX10 med protein som transkripsjonsfaktoren tidleg vekstresponsprotein 2.^[5][7]

Kjelder

1. GRCh38: Ensembl release 89: ENSG00000100146 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033006 - Ensembl, May 2017
3. «PubMed-kjelde for menneske:». National Center for Biotechnology Information, U.S. National Library of Medicine. 
4. «PubMed-kjelde for mus:». National Center for Biotechnology Information, U.S. National Library of Medicine. 
5. Lopez-Anido, Camila; Sun, Guannan; Koenning, Matthias; Srinivasan, Rajini; Hung, Holly A.; Emery, Ben; Keles, Sunduz; Svaren, John (2015). «Differential Sox10 genomic occupancy in myelinating glia». Glia 63 (11): 1897. doi:10.1002/glia.22855. 
6. Fufa, Temesgen D.; Harris, Melissa L.; Watkins-Chow, Dawn E.; Levy, Denise; Gorkin, David U.; Gildea, Derek E.; Song, Lingyun; Safi, Alexias; Crawford, Gregory E.; Sviderskaya, Elena V.; Bennett, Dorothy C.; McCallion, Andrew S.; Loftus, Stacie K.; Pavan, William J. (2015). «Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes». Human Molecular Genetics 24 (19): 5433. PMID 26206884. doi:10.1093/hmg/ddv267. 
7. Li, H.; Lu, Y.; Smith, H. K.; Richardson, W. D. (2007). «Olig1 and Sox10 Interact Synergistically to Drive Myelin Basic Protein Transcription in Oligodendrocytes». Journal of Neuroscience 27 (52): 14375. PMID 18160645. doi:10.1523/JNEUROSCI.4456-07.2007. 

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