Sisi Virginia Khampepe (O belegilwe ka 8 Pheregong 1957[1]) ke moahlodi wa Afrika Borwa yo a šomelagojudge Constitutional Court of South Africa.
Khampepe o belegetšwe Soweto. O hweditše dikiri ya B Proc kua University of Zululand le LLM degree yagwe kua Harvard Law School. O amogetšwe bjale ka Moemedi ka ngwaga wa 1985 , a šoma kua Bowman Gilfillan bjale ka mošomi sekhukhung, bjale ka moemedi wa labour law. ka1995 o kgethilwe bjalo ka leloka la Truth and Reconciliation Commission.[1] Go together ka1999 o kgethilwe bjalo kaDeputy National Director of Public Prosecutions go National Prosecuting Authority.[1]
Ka 2000 Khampepe o kgethilwe bjale ka Moahlodi wa Transvaal Provincial Division ya High Court, (e tsebegang gore ke Gauteng Division). Ka2007 o ile a kgethwa kua Labour Appeal Court, le ka ngwaga wa 2009 o kgethilwe kua Constitutional Court ka Mopresidente Jacob Zuma. ka 2021 o kgethilwe go itšoara ka chief justice ya apex court.