ଫ୍ଲୁଟାମାଇଡ

ଫ୍ଲୁଟାମାଇଡ
Clinical data
Trade namesEulexin, others
SynonymsNiftolide; SCH-13521; 4'-Nitro-3'-trifluoromethyl-isobutyranilide
AHFS/Drugs.commonograph
MedlinePlusa697045
Pregnancy
category
  • D
Routes of
administration		By mouth
Legal status
Legal status
  • ℞ (Prescription only)
Pharmacokinetic data
BioavailabilityComplete (>90%)[୩]
Protein bindingFlutamide: 94–96%[୩]
Hydroxyflutamide: 92–94%[୩]
MetabolismLiver (CYP1A2)[୧][୨]
MetabolitesHydroxyflutamide[୪][୨]
Elimination half-lifeFlutamide: 5–6 hours[୫][୨]
Hydroxyflutamide: 8–10 hours[୬][୭][୨][୩]
ExcretionUrine (mainly)[୩]
Feces (4.2%)[୩]
Identifiers
  • 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
ECHA InfoCard100.033.024 Edit this at Wikidata
Chemical and physical data
FormulaC11H11F3N2O3
Molar mass୨୭୬.୨୨ g·mol−1
3D model (JSmol)
Melting point111.5 to 112.5 °C (232.7 to 234.5 °F)
  • CC(C)C(=O)NC1=CC(=C(C=C1)[N+](=O)[O-])C(F)(F)F
  • InChI=1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17) checkY
  • Key:MKXKFYHWDHIYRV-UHFFFAOYSA-N checkY
  (verify)

ଫ୍ଲୁଟାମାଇଡ, ଅନ୍ୟମାନଙ୍କ ମଧ୍ୟରେ ଏକ ବେପାର ନାମ ଇଉଲେକ୍ସିନ, ହେଉଛି ଏକ ଔଷଧ ଯାହା ମୁଖ୍ୟତଃ ପ୍ରୋଷ୍ଟେଟ୍ କ୍ୟାନସରର ଚିକିତ୍ସା ପାଇଁ ବ୍ୟବହୃତ ହୁଏ ।[୮] ପ୍ରୋଷ୍ଟେଟ କର୍କଟ ପାଇଁ ଏହା ଲ୍ୟୁଟିନାଇଜିଂ ହରମୋନ-ରିଲିଜ୍ ହରମୋନ୍ (LHRH) ସହିତ ମିଳିତ ଭାବରେ ବ୍ୟବହୃତ ହୁଏ ।[୯] ଏହା ଅବାଞ୍ଛିତ କେଶ ବୃଦ୍ଧି ଏବଂ ପଲିସିଷ୍ଟିକ୍ ଓଭାରିଆନ ସିଣ୍ଡ୍ରୋମରେ କେଶ ଝଡ଼ିବା ପାଇଁ ମଧ୍ୟ ବ୍ୟବହୃତ ହୁଏ ।[୧୦] ଏହାକୁ ଦିନକୁ ତିନିଥର ପାଟିରେ ଦିଆଯାଏ ।[୧୧]

ପୁରୁଷମାନଙ୍କ ମଧ୍ୟରେ ସାଧାରଣ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଗରମ ଲାଲିମା, ଯୌନ‌କ୍ରିୟାରେ ଅସୁବିଧା, ସ୍ତନ ବୃଦ୍ଧି ଏବଂ ଅଇ ଲାଗେ ।[୯] ମହିଳାମାନଙ୍କ କ୍ଷେତ୍ରରେ କେବଳ ଶୁଷ୍କ ଚର୍ମ ହେବା ସ‌ହିତ ଏହାକୁ ଭଲ ଭାବରେ ସହ୍ୟ କରିହୁଏ ।[୧୨] ଅନ୍ୟାନ୍ୟ ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟାରେ ଯକୃତ ସମସ୍ୟା, ଲଙ୍ଗ କ୍ୟୁଟି ସିଣ୍ଡ୍ରୋମ, ଏବଂ ଆତପଦାହ ହୋଇପାରେ ।[୯] [୮] ଗର୍ଭାବସ୍ଥାରେ ବ୍ୟବହାର କଲେ ଶିଶୁର କ୍ଷତି ହୋଇପାରେ ।[୯] ଏହା ଏକ ନନ ଷ୍ଟେରଏଡାଲ ଆଣ୍ଟିଆଣ୍ଡ୍ରୋଜେନ (NSA) ଯାହା ଆଣ୍ଡ୍ରୋଜେନ୍ ରିସେପ୍ଟର (ଆର୍) ଚୟନ କରିବା ସ‌ହିତ ଅବରୋଧ କରି କାର୍ଯ୍ୟକ୍ଷମ ହୁଏ ।[୯]

୧୯୬୭ ମସିହାରେ ଫ୍ଲୁଟାମାଇଡ ବିଷୟ ପ୍ରଥମେ ବର୍ଣ୍ଣନା କରାଯାଇଥିଲା ଏବଂ ୧୯୮୩ରେ ଡାକ୍ତରୀ ବ୍ୟବହାର ପାଇଁ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୧୩] ଏହା ୧୯୮୯ରେ ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଅନୁମୋଦିତ ହୋଇଥିଲା ।[୯] ଏହା ବିଶ୍ୱ ସ୍ୱାସ୍ଥ୍ୟ ସଂଗଠନର ଅତ୍ୟାବଶ୍ୟକୀୟ ଔଷଧ ଚିଠାରେ ସ୍ଥାନ ପାଇଛି ।[୧୪] ଏହା ଏକ ସାଧାରଣ ଔଷଧ ଭାବରେ ଉପଲବ୍ଧ ।[୮] ଯୁକ୍ତରାଜ୍ୟରେ ୨୦୨୧ ସୁଦ୍ଧା ୪ ସପ୍ତାହର ଔଷଧ ବ୍ୟବ‌ହାରରର ମୂଲ୍ୟ ୧୧୦ ପାଉଣ୍ଡ ଥିଲା ।[୮] ଯୁକ୍ତରାଷ୍ଟ୍ରରେ ଏହି ରାଶିର ମୂଲ୍ୟ ପ୍ରାୟ ୮୫ ଡଲାର ଥିଲା ।[୧୫] ଏହାର ବ୍ୟବହାରକୁ ବାଇକାଲୁଟାମାଇଡ ଭଳି ଏନଏସଏଏଦ୍ୱାରା ବାରମ୍ବାର ବଦଳା ଯାଇଛି ଯେହେତୁ ଏହା ଭଲ କାମ କରେ, ଏହାର ପାର୍ଶ୍ୱ ପ୍ରତିକ୍ରିୟା କମ ଏବଂ ଗ୍ରହଣ କରିବା ସହଜ ଅଟେ ।[୫] [୧୬]

ଆଧାର

[ସମ୍ପାଦନା]
  1. ↑ Richard A. Lehne (2013). Pharmacology for Nursing Care. Elsevier Health Sciences. pp. 1297–. ISBN 978-1-4377-3582-6. Archived from the original on 2020-07-27. Retrieved 2021-10-05.
  2. ↑ ୨.୦ ୨.୧ ୨.୨ ୨.୩ Bruce A. Chabner; Dan L. Longo (8 November 2010). Cancer Chemotherapy and Biotherapy: Principles and Practice. Lippincott Williams & Wilkins. pp. 679–. ISBN 978-1-60547-431-1. Archived from the original on 14 September 2021. Retrieved 5 October 2021.
  3. ↑ ୩.୦ ୩.୧ ୩.୨ ୩.୩ ୩.୪ ୩.୫ "Flutamide Capsules USP". Archived from the original on 2020-08-12. Retrieved 2021-10-05.
  4. ↑ Diamanti-Kandarakis E (September 1999). "Current aspects of antiandrogen therapy in women". Curr. Pharm. Des. 5 (9): 707–23. PMID 10495361. Archived from the original on 2020-02-27. Retrieved 2021-10-05.
  5. ↑ ୫.୦ ୫.୧ James Leonard Gulley (2011). Prostate Cancer. Demos Medical Publishing. p. 504. ISBN 978-1-935281-91-7. Archived from the original on 2021-12-15. Retrieved 2021-12-14.
  6. ↑ Thomas L. Lemke; David A. Williams (24 January 2012). Foye's Principles of Medicinal Chemistry. Lippincott Williams & Wilkins. pp. 1373–. ISBN 978-1-60913-345-0. Archived from the original on 14 September 2021. Retrieved 5 October 2021.
  7. ↑ Louis J Denis; Keith Griffiths; Amir V Kaisary; Gerald P Murphy (1 March 1999). Textbook of Prostate Cancer: Pathology, Diagnosis and Treatment: Pathology, Diagnosis and Treatment. CRC Press. pp. 279–280. ISBN 978-1-85317-422-3. Archived from the original on 27 July 2020. Retrieved 5 October 2021.
  8. ↑ ୮.୦ ୮.୧ ୮.୨ ୮.୩ BNF 81: March-September 2021. BMJ Group and the Pharmaceutical Press. 2021. p. 992. ISBN 978-0857114105.
  9. ↑ ୯.୦ ୯.୧ ୯.୨ ୯.୩ ୯.୪ ୯.୫ "Flutamide Monograph for Professionals". Drugs.com (in ଇଂରାଜୀ). Archived from the original on 11 October 2018. Retrieved 14 December 2021.
  10. ↑ "Polycystic Ovary Syndrome - Treatment - NHS Choices". Nhs.uk. 2011-10-17. Archived from the original on 2011-11-06. Retrieved 2013-01-04.
  11. ↑ Ismaila A Mungadi; Hyacinth N Mbibu; Ehab Eltahawy; Abdullahi Abdulwahab-Ahmed (30 November 2013). Manual of Medical Treatment in Urology. JP Medical Ltd. pp. 120–. ISBN 978-93-5090-844-0. Archived from the original on 14 September 2021. Retrieved 5 October 2021.
  12. ↑ Fishman, Sarah L.; Paliou, Maria; Poretsky, Leonid; Hembree, Wylie C. (2019). "Endocrine Care of Transgender Adults". Contemporary Endocrinology. pp. 143–163. doi:10.1007/978-3-030-05683-4_8. ISSN 2523-3785. The use of these agents as antiandrogens in transgender patients has been limited by concerns of hepatotoxicity. However, at low doses, these agents have shown to be both well tolerated and effective when used for the treatment of hirsutism [57].
  13. ↑ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery (in ଇଂରାଜୀ). John Wiley & Sons. p. 515. ISBN 9783527607495. Archived from the original on 2020-07-27. Retrieved 2021-10-05.
  14. ↑ World Health Organization (2021). World Health Organization model list of essential medicines: 22nd list (2021). Geneva: World Health Organization. hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
  15. ↑ "Flutamide Prices and Flutamide Coupons - GoodRx". GoodRx. Retrieved 14 December 2021.
  16. ↑ Lutz Moser (1 January 2008). Controversies in the Treatment of Prostate Cancer. Karger Medical and Scientific Publishers. pp. 41–42. ISBN 978-3-8055-8524-8. Archived from the original on 27 July 2020. Retrieved 5 October 2021. Latest studies suggest that [flutamide] also reduces adrenal and ovarian androgen synthesis [58,59].