Receptor 5-HT1D

Receptor 5-HT_1D, receptor serotoninowy 1D – białko transbłonowe kodowane u człowieka genem HTR1D w locus 1p36.3-p34.3, należące do rodziny receptorów serotoninowych^[1].

Funkcja

Gen HTR1D koduje wielokrotnie przechodzące przez błonę komórkową białko transbłonowe pełniące funkcję receptora dla serotoniny (5-hydroksytryptaminy) sprzężonego z białkiem G, którego pobudzenie obniża komórkowy poziom cAMP dzięki białkom G_i i G_o^[2]^[3].

Agonisty

Odwrotne agonisty

metiotepina^[2]

Antagonisty

Przypisy

↑ HTR1D 5-hydroxytryptamine receptor 1D [ Homo sapiens (human) - Gene - NCBI]. [dostęp 2016-08-31].
↑ ^a ^b M.W. Hamblin, M.A. Metcalf. Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. „Mol Pharmacol”. 40 (2), s. 143-148, 1991. PMID: 1652050.
↑ SL. Lin, S. Setya, N.N. Johnson-Farley, DS. Cowen. Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family. „Br J Pharmacol”. 136 (7), s. 1072-1078, 2002. DOI: 10.1038/sj.bjp.0704809. PMID: 12145108.
↑ R.A. Glennon, S.S. Hong, M. Dukat, M. Teitler i inni. 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. „Journal of Medicinal Chemistry.”. 37 (18), s. 2828-2830, 1994. PMID: 8071931.
↑ ^a ^b J.E. Leysen, W. Gommeren, L. Heylen, W.H. Luyten i inni. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. „Mol Pharmacol”. 50 (6), s. 1567-1580, 1996. PMID: 8967979.
↑ ^a ^b ^c ^d ^e ^f ^g ^h A. Schotte, P.F. Janssen, W. Gommeren, W.H. Luyten i inni. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. „Psychopharmacology”. 124 (1-2), s. 57-73, 1996. PMID: 8935801.

Linki zewnętrzne

R. Andrade et al.: 5-HT1D receptor - 5-Hydroxytryptamine receptors. IUPHAR/BPS Guide to PHARMACOLOGY, 2015-08-04. [dostęp 2016-08-31].

[1] HTR1D 5-hydroxytryptamine receptor 1D [ Homo sapiens (human) - Gene - NCBI]. [dostęp 2016-08-31].

[Hamblin-2] M.W. Hamblin, M.A. Metcalf. Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. „Mol Pharmacol”. 40 (2), s. 143-148, 1991. PMID: 1652050.

[3] SL. Lin, S. Setya, N.N. Johnson-Farley, DS. Cowen. Differential coupling of 5-HT(1) receptors to G proteins of the G(i) family. „Br J Pharmacol”. 136 (7), s. 1072-1078, 2002. DOI: 10.1038/sj.bjp.0704809. PMID: 12145108.

[4] R.A. Glennon, S.S. Hong, M. Dukat, M. Teitler i inni. 5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. „Journal of Medicinal Chemistry.”. 37 (18), s. 2828-2830, 1994. PMID: 8071931.

[Leysen-5] J.E. Leysen, W. Gommeren, L. Heylen, W.H. Luyten i inni. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. „Mol Pharmacol”. 50 (6), s. 1567-1580, 1996. PMID: 8967979.

[Schotte1996-6] ↑ ^a ^b ^c ^d ^e ^f ^g ^h A. Schotte, P.F. Janssen, W. Gommeren, W.H. Luyten i inni. Risperidone compared with new and reference antipsychotic drugs: in vitro and in vivo receptor binding. „Psychopharmacology”. 124 (1-2), s. 57-73, 1996. PMID: 8935801.

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