Abridor de canal de potássio

Os abridores de canais de potássio são uma classe de fármacos que facilitam a transmissão de íons através dos canais de potássio.

Exemplos

Alguns exemplos incluem:

Diazoxida,^[1] vasodilatador usado para hipertensão, atividade relaxante do músculo liso
Minoxidil,^[2] usado para hipertensão, mas também para tratar alopécia de cabelo
Nicorandil,^[3] usado para tratar angina
Pinacidil^[4]
Retigabina,^[5]^[6] um anticonvulsivante
Flupirtina, analgésico com propriedades anticonvulsivantes e relaxantes musculares

Referências

↑ Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (agosto de 2005). «Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener». Circulation. 112 (9 Suppl): I219–23. PMID 16159820. doi:10.1161/CIRCULATIONAHA.104.523746
↑ Wang T (fevereiro de 2003). «The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle». J. Pharmacol. Exp. Ther. 304 (2): 833–40. PMID 12538840. doi:10.1124/jpet.102.043380
↑ Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (novembro de 2008). «Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction». Biol. Pharm. Bull. 31 (11): 2079–82. PMID 18981577. doi:10.1248/bpb.31.2079
↑ Stojnic, Natasa; Gojkovic-Bukarica, Ljiljana; Peric, Miodrag; Grbovic, Leposava; Lesic, Aleksandar; Bumbasirevic, Marko; Heinle, Helmut (2007). «Potassium Channel Opener Pinacidil Induces Relaxation of the Isolated Human Radial Artery». Journal of Pharmacological Sciences (2): 122–129. doi:10.1254/jphs.FP0061434. Consultado em 12 de dezembro de 2021
↑ Rundfeldt C (outubro de 1997). «The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells». European Journal of Pharmacology. 336 (2–3): 243–9. PMID 9384239. doi:10.1016/S0014-2999(97)01249-1
↑ Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (agosto de 2000). «Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine». Molecular Pharmacology. 58 (2): 253–62. PMID 10908292. doi:10.1124/mol.58.2.253

[pmid16159820-1] Mizutani S, Prasad SM, Sellitto AD, Schuessler RB, Damiano RJ, Lawton JS (agosto de 2005). «Myocyte volume and function in response to osmotic stress: observations in the presence of an adenosine triphosphate-sensitive potassium channel opener». Circulation. 112 (9 Suppl): I219–23. PMID 16159820. doi:10.1161/CIRCULATIONAHA.104.523746

[pmid12538840-2] Wang T (fevereiro de 2003). «The effects of the potassium channel opener minoxidil on renal electrolytes transport in the loop of henle». J. Pharmacol. Exp. Ther. 304 (2): 833–40. PMID 12538840. doi:10.1124/jpet.102.043380

[pmid18981577-3] Sudo H, Yogo K, Ishizuka N, Otsuka H, Horie S, Saito K (novembro de 2008). «Nicorandil, a potassium channel opener and nitric oxide donor, improves the frequent urination without changing the blood pressure in rats with partial bladder outlet obstruction». Biol. Pharm. Bull. 31 (11): 2079–82. PMID 18981577. doi:10.1248/bpb.31.2079

[4] Stojnic, Natasa; Gojkovic-Bukarica, Ljiljana; Peric, Miodrag; Grbovic, Leposava; Lesic, Aleksandar; Bumbasirevic, Marko; Heinle, Helmut (2007). «Potassium Channel Opener Pinacidil Induces Relaxation of the Isolated Human Radial Artery». Journal of Pharmacological Sciences (2): 122–129. doi:10.1254/jphs.FP0061434. Consultado em 12 de dezembro de 2021

[pmid9384239-5] Rundfeldt C (outubro de 1997). «The new anticonvulsant retigabine (D-23129) acts as an opener of K+ channels in neuronal cells». European Journal of Pharmacology. 336 (2–3): 243–9. PMID 9384239. doi:10.1016/S0014-2999(97)01249-1

[pmid10908292-6] Main MJ, Cryan JE, Dupere JR, Cox B, Clare JJ, Burbidge SA (agosto de 2000). «Modulation of KCNQ2/3 potassium channels by the novel anticonvulsant retigabine». Molecular Pharmacology. 58 (2): 253–62. PMID 10908292. doi:10.1124/mol.58.2.253

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