CD38

O CD38 (também conhecido como T10) é uma ectoenzima multifuncional cujo gene codificador localiza-se no braço curto do cromossomo 4 (na espécie Homo sapiens). É amplamente expressa nas células e tecidos humanos, especialmente nos leucócitos.

Possui participação na adesão celular, transdução de sinais e nas vias de sinalização que envolvem o cálcio.

Leitura de apoio

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  • Partidá-Sánchez S, Rivero-Nava L, Shi G, Lund FE (2007). «CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses.». Adv. Exp. Med. Biol. 590: 171–83. PMID 17191385. doi:10.1007/978-0-387-34814-8_12 
  • Jackson DG, Bell JI (1990). «Isolation of a cDNA encoding the human CD38 (T10) molecule, a cell surface glycoprotein with an unusual discontinuous pattern of expression during lymphocyte differentiation.». J. Immunol. 144 (7): 2811–5. PMID 2319135 
  • Dianzani U, Bragardo M, Buonfiglio D; et al. (1995). «Modulation of CD4 lateral interaction with lymphocyte surface molecules induced by HIV-1 gp120.». Eur. J. Immunol. 25 (5): 1306–11. PMID 7539755. doi:10.1002/eji.1830250526 
  • Nakagawara K, Mori M, Takasawa S; et al. (1995). «Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15.». Cytogenet. Cell Genet. 69 (1-2): 38–9. PMID 7835083. doi:10.1159/000133933 
  • Tohgo A, Takasawa S, Noguchi N; et al. (1994). «Essential cysteine residues for cyclic ADP-ribose synthesis and hydrolysis by CD38.». J. Biol. Chem. 269 (46): 28555–7. PMID 7961800 
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  • Nata K, Takamura T, Karasawa T; et al. (1997). «Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.». Gene. 186 (2): 285–92. PMID 9074508. doi:10.1016/S0378-1119(96)00723-8 
  • Feito MJ, Bragardo M, Buonfiglio D; et al. (1997). «gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules.». Int. Immunol. 9 (8): 1141–7. PMID 9263011. doi:10.1093/intimm/9.8.1141 
  • Ferrero E, Malavasi F (1997). «Human CD38, a leukocyte receptor and ectoenzyme, is a member of a novel eukaryotic gene family of nicotinamide adenine dinucleotide+-converting enzymes: extensive structural homology with the genes for murine bone marrow stromal cell antigen 1 and aplysian ADP-ribosyl cyclase.». J. Immunol. 159 (8): 3858–65. PMID 9378973 
  • Deaglio S, Morra M, Mallone R; et al. (1998). «Human CD38 (ADP-ribosyl cyclase) is a counter-receptor of CD31, an Ig superfamily member.». J. Immunol. 160 (1): 395–402. PMID 9551996 
  • Yagui K, Shimada F, Mimura M; et al. (1998). «A missense mutation in the CD38 gene, a novel factor for insulin secretion: association with Type II diabetes mellitus in Japanese subjects and evidence of abnormal function when expressed in vitro.». Diabetologia. 41 (9): 1024–8. PMID 9754820. doi:10.1007/s001250051026