EPH receptor A1

Estrutura tridimensional da EPHA1

EPH receptor A1 (ephrin type-A receptor 1) é uma proteína que em humanos é codificada pelo gene EPHA1.

Está relacionada com a Doença de Alzheimer e em vários tipos de câncer.[1]

Referências

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  1. ↑ G1. Cientistas descobrem cinco novos genes de risco de Alzheimer. Acesso em 4 de abril de 2011

Leitura adicional

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  • Flanagan JG, Vanderhaeghen P (1998). «The ephrins and Eph receptors in neural development.». Annu. Rev. Neurosci. 21: 309–45. PMID 9530499. doi:10.1146/annurev.neuro.21.1.309 
  • Zhou R (1998). «The Eph family receptors and ligands.». Pharmacol. Ther. 77 (3): 151–81. PMID 9576626. doi:10.1016/S0163-7258(97)00112-5 
  • Holder N, Klein R (1999). «Eph receptors and ephrins: effectors of morphogenesis.». Development. 126 (10): 2033–44. PMID 10207129 
  • Wilkinson DG (2000). «Eph receptors and ephrins: regulators of guidance and assembly.». Int. Rev. Cytol. 196: 177–244. PMID 10730216. doi:10.1016/S0074-7696(00)96005-4 
  • Xu Q, Mellitzer G, Wilkinson DG (2001). «Roles of Eph receptors and ephrins in segmental patterning.». Philos. Trans. R. Soc. Lond., B, Biol. Sci. 355 (1399): 993–1002. PMC 1692797Acessível livremente. PMID 11128993. doi:10.1098/rstb.2000.0635 
  • Wilkinson DG (2001). «Multiple roles of EPH receptors and ephrins in neural development.». Nat. Rev. Neurosci. 2 (3): 155–64. PMID 11256076. doi:10.1038/35058515 
  • Hirai H, Maru Y, Hagiwara K; et al. (1988). «A novel putative tyrosine kinase receptor encoded by the eph gene.». Science. 238 (4834): 1717–20. PMID 2825356. doi:10.1126/science.2825356 
  • Gale NW, Holland SJ, Valenzuela DM; et al. (1996). «Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis.». Neuron. 17 (1): 9–19. PMID 8755474. doi:10.1016/S0896-6273(00)80276-7 
  • Owshalimpur D, Kelley MJ (1999). «Genomic structure of the EPHA1 receptor tyrosine kinase gene.». Mol. Cell. Probes. 13 (3): 169–73. PMID 10369740. doi:10.1006/mcpr.1999.0228 
  • Kalo MS, Pasquale EB (outubro de 1999). «Signal transfer by eph receptors». Cell and tissue research. 298 (1): 1–9. PMID 10502115 
  • Coulthard MG, Lickliter JD, Subanesan N; et al. (2002). «Characterization of the Epha1 receptor tyrosine kinase: expression in epithelial tissues.». Growth Factors. 18 (4): 303–17. PMID 11519828. doi:10.3109/08977190109029118 
  • Hillier LW, Fulton RS, Fulton LA; et al. (2003). «The DNA sequence of human chromosome 7.». Nature. 424 (6945): 157–64. PMID 12853948. doi:10.1038/nature01782 
  • Brandenberger R, Wei H, Zhang S; et al. (2005). «Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation.». Nat. Biotechnol. 22 (6): 707–16. PMID 15146197. doi:10.1038/nbt971