Epiandrosterona

Fórmula esquelética da epiandrosterona.
CAS: 481-29-8.
Modelo da epiandrosterona.

A epiandrosterona ou isoandrosterona,[1][2] também chamada 3β-androsterona, 3β-hidroxi-5α-androstan-17-ona ou 5α-androstan-3β-ol-17-ona,[3] é uma hormona esteróide com uma débil actividade androgénica. É um metabólito da testosterona e di-hidrotestosterona (DHT).

A epiandrosterona aparece de forma natural na maioria dos mamíferos, entre eles os porcos.[4]

A epiandrosterona produz a enzima 5α-redutase a partir da hormona adrenal desidroepiandrosterona (DHEA).[5][6][7][8][9]

Ver também

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Referências

  1. ↑ Samuel H. Yalkowsky; Yan He; Parijat Jain (19 de abril de 2016). Handbook of Aqueous Solubility Data, Second Edition. [S.l.]: CRC Press. pp. 1209–. ISBN 978-1-4398-0246-5 
  2. ↑ Natural Products. [S.l.]: Krishna Prakashan Media. 2006. pp. 298–. ISBN 978-81-87224-85-3 
  3. ↑ ChemSpider Epiandrosterone
  4. ↑ Raeside JI, Renaud RL, Marshall DE. Identification of 5 alpha-androstane-3 beta,17 beta-diol and 3 beta-hydroxy-5 alpha-androstan-17-one sulfates as quantitatively significant secretory products of porcine Leydig cells and their presence in testicular venous blood. J Steroid Biochem Mol Biol. 42(1):113-20, 1992. PMID 1558816
  5. ↑ PubChem Epiandrosterone
  6. ↑ Callies F, Arlt W, Siekmann L, Hübler D, Bidlingmaier F, Allolio B. Influence of oral dehydroepiandrosterone (DHEA) on urinary steroid metabolites in males and females. Steroids. 65(2):98-102, 2000. PMID 10639021
  7. ↑ Labrie F, Cusan L, Gomez JL, Martel C, Bérubé R, Bélanger P, Chaussade V, Deloche C, Leclaire J. Changes in serum DHEA and eleven of its metabolites during 12-month percutaneous administration of DHEA. J Steroid Biochem Mol Biol. 2008 May;110(1-2):1-9. PMID 18359622. DOI 10.1016/j.jsbmb.2008.02.003
  8. ↑ Daniël Henri van de Kerkhof. Steroid profiling in doping analysis. [S.l.] : [s.n.], 2001 - Tekst. - Proefschrift Universiteit Utrecht [1]
  9. ↑ Acacio BD, Stanczyk FZ, Mullin P, Saadat P, Jafarian N, Sokol RZ. Pharmacokinetics of dehydroepiandrosterone and its metabolites after long-term daily oral administration to healthy young men. Fertil Steril. Mar;81(3):595-604, 2004. PMID 15037408. DOI 10.1016/j.fertnstert.2003.07.035

Bibliografia

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  • Simons RG, Grinwich DL. Immunoreactive detection of four mammalian steroids in plants. Can J Bot 67: 288-296, 1989
  • Janeczko A, Skoczowski A. Mammalian sex hormones in plants. Folia Histochem Cytobiol. 2005;43(2):71-9.Labrie F, Bélanger A, Labrie C, Candas B, Cusan L, Gomez 4. JL. Bioavailability and metabolism of oral and percutaneous dehydroepiandrosterone in postmenopausal women. J Steroid Biochem Mol Biol. 107(1-2):57-69, 2007
  • Uralets VP, Gillette PA. Over-the-counter delta5 anabolic steroids 5-androsen-3,17-dione; 5-androsten-3beta, 17beta-diol; dehydroepiandrosterone; and 19-nor-5-androsten-3,17-dione: excretion studies in men. J Anal Toxicol. 24(3):188-93, 2000