A Fox renovou American Dad! Para uma quinta temporada para começar a produção em 27 de setembro de 2009. A quinta temporada de American Dad! celebra o marco episódio 100, encontra Steve acidentalmente lançar um avião militar secreto, e Francine e Stan renovar seus votos de casamento. Esta é a primeira temporada de American Dad a ser transmitido em alta definição a partir da linha de produção 5AJNxx midseason, em 2010.
Pilot • Threat Levels • Stan Knows Best • Francine's Flashback • Roger Codger • Homeland Insecurity • Deacon Stan, Jesus Man • Bullocks to Stan • A Smith in the Hand • All About Steve • Con Heir • Stan of Arabia: Part 1 • Stan of Arabia: Part 2 • Stannie Get Your Gun • Star Trek • Not Particularly Desperate Housewife • Rough Trade • Finances with Wolves • It's Good to Be Queen • Roger 'n' Me • Helping Handis • With Friends Like Steve's • Tears of a Clooney
Camp Refoogee • The American Dad After School Special • Failure Is not a Factory-Installed Option • Lincoln Lover • Dungeons and Wagons • Iced, Iced Babies • Of Ice and Men • Irregarding Steve • The Best Christmas Story Never Told • Bush Comes to Dinner • American Dream Factory • A.T. the Abusive Terrestrial • Black Mystery Month • An Apocalypse to Remember • Four Little Words • When a Stan Loves a Woman • I Can't Stan You • The Magnificent Steven • Joint Custody
The Vacation Goo • Meter Made • Dope & Faith • Big Trouble in Little Langley • Haylias • 42-Year-Old Virgin • Surro-Gate • The Most Adequate Christmas Ever • Frannie 911 • Tearjerker • Oedipal Panties • Widowmaker • Red October Sky • Office Spaceman • Stanny Slickers II: The Legend of Ollie's Gold • Spring Breakup
1600 Candles • The One That Got Away • One Little Word • Choosy Wives Choose Smith • Escape from Pearl Bailey • Pulling Double Booty • Phantom of the Telethon • Chimdale • Stan Time • Family Affair • Live and Let Fry • Roy Rogers McFreely • Jack's Back • Bar Mitzvah Shuffle • Wife Insurance • Delorean Story-an • Every Which Way But Lose • Weiner of Our Discontent • Daddy Queerest • Stan's Night Out
In Country...Club • Moon Over Isla Island • Home Adrone • Brains, Brains and Automobiles • Man in the Moonbounce • Shallow Vows • My Morning Straitjacket • G-String Circus • Rapture's Delight • Don't Look a Smith Horse in the Mouth • A Jones for a Smith • May the Best Stan Win • The Return of the Bling • Cops and Roger • Merlot Down Dirty Shame • Bully for Steve • An Incident at Owl Creek • Great Space Roaster
You Debt Your Life • Son of Stan • There Will Be Bad Blood • I Am the Walrus • For Whom the Sleigh Bell Tolls • 100 A.D. • A Pinata Named Desire • Best Little Horror House in Langley Falls • Call An Ambulance • Fartbreak Hotel • Licence to Till • Stanny-Boy and Frantastic • Stan's Food Restaurant • White Rice
Mike Barker • Matt Weitzman • Seth MacFarlane • David Zuckerman • Rick Wiener • Kenny Schwartz • Crystal Khan • Michael Shipley • Jim Bernstein • teve Hely • Chris McKenna • Matt McKenna • Dan Vebber • Jon Fener] • Josh Bycel • Dave Locke • John Fitch