4-Hidroksi-2-oksoglutaratna aldolaza
| 4-Hidroksi-2-oksoglutaratna aldolaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 4.1.3.16 | ||||||||
| CAS broj | 9030-81-3 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
4-Hidroksi-2-oksoglutaratna aldolaza (EC 4.1.3.16, 2-okso-4-hidroksiglutaratna aldolaza, hidroksiketoglutarinska aldolaza, 4-hidroksi-2-ketoglutarinska aldolaza, 2-keto-4-hidroksiglutarinska aldolaza, 4-hidroksi-2-ketoglutaratna aldolaza, 2-keto-4-hidroksiglutaratna aldolaza, 2-okso-4-hidroksiglutarinska aldolaza, DL-4-hidroksi-2-ketoglutaratna aldolaza, hidroksiketoglutaratna aldolaza, 2-keto-4-hidroksibutiratna aldolaza, 4-hidroksi-2-oksoglutaratna glioksilat-lijaza, KHGA) je enzim sa sistematskim imenom 4-hidroksi-2-oksoglutarat glioksilat-lijaza (formira piruvat).[1][2][3][4] Ovaj enzim katalizuje sledeću hemijsku reakciju
- 4-hidroksi-2-oksoglutarat piruvat + glioksilat
Ovaj enzim deluje na oba enantiomera.
- ↑ Kuratomi, K. and Fukunaga, K. (1963). „The metabolism of γ-hydroxyglutamate in rat liver. I. Enzymic synthesis of γ-hydroxy-α-ketoglutarate from pyruvate and glyoxalate”. Biochim. Biophys. Acta 78: 617-628. PMID 14089442.
- ↑ Nishihara, H. (1971). „2-Keto-4-hydroxybutyrate aldolase. Identification as 2-keto-4-hydroxyglutarate aldolase, catalytic properties, and role in the mammalian metabolism of L-homoserine”. Biochemistry 10: 1353-1364. PMID 5580656.
- ↑ Nishihara, H. and Dekker, E.E. (1972). „Purification, substrate specificity and binding, β-decarboxylase activity, and other properties of Escherichia coli 2-keto-4-hydroxyglutarate aldolase”. J. Biol. Chem. 247: 5079-5087. PMID 4560498.
- ↑ Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 281-302.
- Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X.
- Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036.
- Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0.
- Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097.
- Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X.
- Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842.
- Wood, W.A. (1972). „2-Keto-3-deoxy-6-phosphogluconic and related aldolases”. u: Boyer, P.D.. The Enzymes. 7 (3rd izd.). New York: Academic Press. str. 281-302.