Alfa-2A adrenergički receptor

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Adrenergički alfa-2A receptor
PDB prikaz baziran na 1hll.
Dostupne strukture
1hll, 1ho9, 1hod, 1hof
Identifikatori
Simboli	ADRA2A; ADRA2; ADRA2R; ADRAR; ALPHA2AAR; ZNF32
Vanjski ID	OMIM: 104210 MGI: 87934 HomoloGene: 47944 IUPHAR: α2A-adrenoceptor GeneCards: ADRA2A Gene
Ontologija gena Molekularna funkcija • aktivnost rodopsinu-sličnog receptora • receptorska aktivnost • adrenoceptorska aktivnost • aktivnost alfa2-adrenergičkog receptora • proteinsko vezivanje • aktivnost regulatora kalijumskog kanala Celularna komponenta • ćelijska membrana • integralno sa ćelijskom membranom Biološki proces • aktivacija MAPK aktivnosti • ćelijska motilnost • prenos signala • signalni put G-protein spregnutog receptora • negativna regulacija aktivnosti adenilat ciklaze • transdukcija Ro protein signala • pozitivna regulacija ćelijske proliferacije • aktinska citoskeletonska organizacija i biogeneza • odgovor na strah
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta	Čovek	Miš
Entrez	150	11551
Ensembl	ENSG00000150594	ENSMUSG00000033717
UniProt	P08913	Q1HL33
RefSeq (mRNA)	NM_000681	XM_974141
RefSeq (protein)	NP_000672	XP_979235
Lokacija (UCSC)	Chr 10: 112.83 - 112.83 Mb	Chr 19: 54.1 - 54.1 Mb
PubMed pretraga	[1]	[2]

Alfa-2A adrenergički receptor (α_2A adrenoceptor, ADRA2A) je alfa-2 adrenergički receptor. On je kodiran humanim ADRA2A genom.^[1]

Receptor

Alfa-2-adrenergički receptori su 3 visoko homologna podtipa: alfa_2A, alfa_2B, i alfa_2C. Ti receptori imaju kritičnu ulogu u regulaciji otpuštanja neurotransmitera iz simpatičkih nerva i iz adrenergičkih neurona centralnog nervnog sistema. Ispitivanja na miševima su pokazala da su oba, alfa_2A i alfa_2C, podtipa neophodna za normalnu presinaptičku kontrolu otpuštanja transmitera iz simpatičkih nerva u srcu i iz centralnih noradrenergičkih neurona. Alfa_2A podtip inhibira otpuštanje transmitera na visokim stimulacionim frekvencijama, dok alfa_2C podtip modulira neurotransmisiju na niskim nivoima nervne aktivnosti.

Gen

Ovaj gen kodira alfa_2A tip receptora. On ne sadrži introne.^[1]

Selektivni ligandi

Agonisti

• Gvanfacin
• Klonidin

Antagonisti

• BRL-44408
• Johimbin

Povezano

• Adrenergički receptor

Reference

1. „Entrez Gene: ADRA2A adrenergic, alpha-2A-, receptor”. 

Literatura

• Perälä M, Hirvonen H, Kalimo H, et al. (1993). „Differential expression of two alpha 2-adrenergic receptor subtype mRNAs in human tissues.”. Brain Res. Mol. Brain Res. 16 (1-2): 57–63. DOI:10.1016/0169-328X(92)90193-F. PMID 1334200. 
• Surprenant A, Horstman DA, Akbarali H, Limbird LE (1992). „A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents.”. Science 257 (5072): 977–80. DOI:10.1126/science.1354394. PMID 1354394. 
• Handy DE, Gavras H (1992). „Promoter region of the human alpha 2A adrenergic receptor gene.”. J. Biol. Chem. 267 (33): 24017–22. PMID 1385431. 
• Suryanarayana S, Daunt DA, Von Zastrow M, Kobilka BK (1991). „A point mutation in the seventh hydrophobic domain of the alpha 2 adrenergic receptor increases its affinity for a family of beta receptor antagonists.”. J. Biol. Chem. 266 (23): 15488–92. PMID 1678390. 
• Wang CD, Buck MA, Fraser CM (1991). „Site-directed mutagenesis of alpha 2A-adrenergic receptors: identification of amino acids involved in ligand binding and receptor activation by agonists.”. Mol. Pharmacol. 40 (2): 168–79. PMID 1678850. 
• Chhajlani V, Rangel N, Uhlén S, Wikberg JE (1991). „Identification of an additional gene belonging to the alpha 2 adrenergic receptor family in the human genome by PCR.”. FEBS Lett. 280 (2): 241–4. DOI:10.1016/0014-5793(91)80301-I. PMID 1849485. 
• Guyer CA, Horstman DA, Wilson AL, et al. (1990). „Cloning, sequencing, and expression of the gene encoding the porcine alpha 2-adrenergic receptor. Allosteric modulation by Na+, H+, and amiloride analogs.”. J. Biol. Chem. 265 (28): 17307–17. PMID 2170371. 
• Fraser CM, Arakawa S, McCombie WR, Venter JC (1989). „Cloning, sequence analysis, and permanent expression of a human alpha 2-adrenergic receptor in Chinese hamster ovary cells. Evidence for independent pathways of receptor coupling to adenylate cyclase attenuation and activation.”. J. Biol. Chem. 264 (20): 11754–61. PMID 2568356. 
• Kobilka BK, Matsui H, Kobilka TS, et al. (1987). „Cloning, sequencing, and expression of the gene coding for the human platelet alpha 2-adrenergic receptor.”. Science 238 (4827): 650–6. DOI:10.1126/science.2823383. PMID 2823383. 
• Lynch CJ, Steer ML (1981). „Evidence for high and low affinity alpha 2-receptors. Comparison of [3H]norepinephrine and [3H]phentolamine binding to human platelet membranes.”. J. Biol. Chem. 256 (7): 3298–303. PMID 6259160. 
• Eason MG, Moreira SP, Liggett SB (1995). „Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated phosphorylation and desensitization of the alpha 2A-adrenergic receptor.”. J. Biol. Chem. 270 (9): 4681–8. DOI:10.1074/jbc.270.9.4681. PMID 7876239. 
• Grassie MA, Milligan G (1995). „Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblasts.”. Biochem. J. 306 ( Pt 2): 525–30. PMC 1136549. PMID 7887906. 
• Shilo L, Sakaue M, Thomas JM, et al. (1994). „Enhanced transcription of the human alpha 2A-adrenergic receptor gene by cAMP: evidence for multiple cAMP responsive sequences in the promoter region of this gene.”. Cell. Signal. 6 (1): 73–82. DOI:10.1016/0898-6568(94)90062-0. PMID 8011430. 
• Valet P, Senard JM, Devedjian JC, et al. (1993). „Characterization and distribution of alpha 2-adrenergic receptors in the human intestinal mucosa.”. J. Clin. Invest. 91 (5): 2049–57. DOI:10.1172/JCI116427. PMC 288203. PMID 8098045. 
• Alblas J, van Corven EJ, Hordijk PL, et al. (1993). „Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.”. J. Biol. Chem. 268 (30): 22235–8. PMID 8226727. 
• Klein U, Ramirez MT, Kobilka BK, von Zastrow M (1997). „A novel interaction between adrenergic receptors and the alpha-subunit of eukaryotic initiation factor 2B.”. J. Biol. Chem. 272 (31): 19099–102. DOI:10.1074/jbc.272.31.19099. PMID 9235896. 
• Bétuing S, Daviaud D, Pagès C, et al. (1998). „Gbeta gamma-independent coupling of alpha2-adrenergic receptor to p21(rhoA) in preadipocytes.”. J. Biol. Chem. 273 (25): 15804–10. DOI:10.1074/jbc.273.25.15804. PMID 9624180. 
• Prezeau L, Richman JG, Edwards SW, Limbird LE (1999). „The zeta isoform of 14-3-3 proteins interacts with the third intracellular loop of different alpha2-adrenergic receptor subtypes.”. J. Biol. Chem. 274 (19): 13462–9. DOI:10.1074/jbc.274.19.13462. PMID 10224112. 
• Hein L, Altman JD, Kobilka BK (2000). „Two functionally distinct alpha2-adrenergic receptors regulate sympathetic neurotransmission.”. Nature 402 (6758): 181–4. DOI:10.1038/46040. PMID 10647009. 
• Schaak S, Cussac D, Cayla C, et al. (2000). „Alpha(2) adrenoceptors regulate proliferation of human intestinal epithelial cells.”. Gut 47 (2): 242–50. DOI:10.1136/gut.47.2.242. PMC 1728001. PMID 10896916. 

Spoljašnje veze

• „α_2A-adrenoceptor”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-04-02.