Aminodezoksihorizmat sintaza
| Aminodezoksihorizmat sintaza | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifikatori | |||||||||
| EC broj | 2.6.1.85 | ||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB | RCSB PDB PDBe PDBj PDBsum | ||||||||
| |||||||||
Aminodezoksihorizmat sintaza (EC 2.6.1.85, ADC sintaza, 4-amino-4-dezoksihorizmatna sintaza, PabB, horizmat:L-glutamin amido-ligaza) je enzim sa sistematskim imenom horizmat:L-glutamin aminotransferaza.[1][2] Ovaj enzim katalizuje sledeću hemijsku reakciju
Ovaj enzim se sastoji od dva dela, PabA i PabB. U odsustvu PabA i glutamina, PabB konvertuje amonijak i horizmat u 4-amino-4-dezoksihorizmat (u prisustvu Mg2+). PabA konvertuje glutamin u glutamat samo kad je prisutna stohiometrijka količina PabB. Ovaj enzim se spreže sa EC 4.1.3.38, aminodezoksihorizmatnom lijazom, da formira 4-aminobenzoat.
- ↑ Ye, Q.Z., Liu, J. and Walsh, C.T. (1990). „p-Aminobenzoate synthesis in Escherichia coli: purification and characterization of PabB as aminodeoxychorismate synthase and enzyme X as aminodeoxychorismate lyase”. Proc. Natl. Acad. Sci. USA 87: 9391-9395. PMID 2251281.
- ↑ Viswanathan, V.K., Green, J.M. and Nichols, B.P. (1995). „Kinetic characterization of 4-amino 4-deoxychorismate synthase from Escherichia coli”. J. Bacteriol. 177: 5918-5923. PMID 7592344.
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